Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation

ERK: A Key Player in the Pathophysiology of Cardiac Hypertrophy

(2019) Simona Gallo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IMM-H007 improves heart function via reducing cardiac fibrosis

(2019) Weipeng Ge et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Angiotensin II receptor blocker LCZ696 attenuates cardiac remodeling through the inhibition of the ERK signaling pathway in mice with pregnancy-associated cardiomyopathy

(2019) Yi Wang et al.   Cell and Bioscience

Macrophages in cardiac repair: Environmental cues and therapeutic strategies

(2019) Geoffrey de Couto   EXPERIMENTAL AND MOLECULAR MEDICINE

The anti-inflammatory peptide Ac-SDKP: Synthesis, role in ACE inhibition, and its therapeutic potential in hypertension and cardiovascular diseases

(2018) Nitin Kumar et al.   PHARMACOLOGICAL RESEARCH

Role of meprin metalloproteinases in cytokine processing and inflammation

(2018) Christian Herzog et al.   CYTOKINE

IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult

(2017) Han Xiao et al.   EUROPEAN HEART JOURNAL

Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and DysfunctionNovelty and Significance

(2016) Lin Zhao et al.   CIRCULATION RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Thymosin β4 Prevents Angiotensin II-Induced Cardiomyocyte Growth by Regulating Wnt/WISP Signaling

(2016) Li Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Monocyte and macrophage contributions to cardiac remodeling

(2016) Maarten Hulsmans et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Physiological and pathological cardiac hypertrophy

(2016) Ippei Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway

(2016) Mei-ping Wu et al.   PHARMACOLOGICAL RESEARCH

PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction

(2016) Walter E. Knight et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Cell and Other Noncardiomyocyte Regulation of Cardiac Hypertrophy and Remodeling

(2015) R. A. Frieler et al.   CIRCULATION

Meprin α and meprin β: Procollagen proteinases in health and disease

(2015) Johannes Prox et al.   MATRIX BIOLOGY

5TNF-α and IL-1β Neutralization Ameliorates Angiotensin II-Induced Cardiac Damage in Male Mice

(2014) Yueli Wang et al.   ENDOCRINOLOGY

Meprin Metalloproteases Inactivate Interleukin 6

(2014) Timothy R. Keiffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis

(2014) Thomas Moore-Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4

(2013) Jun Mori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

(2013) Claudia Broder et al.   BIOCHEMICAL JOURNAL

Metalloproteases meprin   and meprin   are C- and N-procollagen proteinases important for collagen assembly and tensile strength

(2013) C. Broder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of oxidative stress by oxidized LDL via meprinα-activated epidermal growth factor receptor in macrophages

(2012) Pan Gao et al.   CARDIOVASCULAR RESEARCH

Meprinα Transactivates the Epidermal Growth Factor Receptor (EGFR) via Ligand Shedding, thereby Enhancing Colorectal Cancer Cell Proliferation and Migration

(2012) Petra Minder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Interleukin-1 Activity Contributes to Exercise Intolerance in Patients with Systolic Heart Failure

(2012) Benjamin W. Van Tassell et al.   PLoS One

Macrophage-Stimulated Cardiac Fibroblast Production of IL-6 Is Essential for TGF β/Smad Activation and Cardiac Fibrosis Induced by Angiotensin II

(2012) Feifei Ma et al.   PLoS One

Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell

(2011) Akira Kudo   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of monocytes and inflammation in the pathophysiology of heart failure

(2011) Benjamin J. Wrigley et al.   EUROPEAN JOURNAL OF HEART FAILURE

Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice

(2011) Hongmei Peng et al.   EXPERIMENTAL PHYSIOLOGY

Actinonin, a Meprin a Inhibitor, Protects the Renal Microcirculation During Sepsis

(2010) Zhen Wang et al.   SHOCK

A meprin inhibitor suppresses atherosclerotic plaque formation in ApoE−/− mice

(2009) Pan Gao et al.   ATHEROSCLEROSIS

Meprin A and meprin α generate biologically functional IL-1β from pro-IL-1β

(2009) Christian Herzog et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease

(2009) S Banerjee et al.   Mucosal Immunology

Meprin-α metalloproteases enhance lipopolysaccharide-stimulated production of tumour necrosis factor-α and interleukin-1β in peripheral blood mononuclear cells via activation of NF-κB

(2009) Pan Gao et al.   REGULATORY PEPTIDES