The Relationship between Reactive Oxygen Species and the cGAS/STING Signaling Pathway in the Inflammaging Process
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Title
The Relationship between Reactive Oxygen Species and the cGAS/STING Signaling Pathway in the Inflammaging Process
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 23, Pages 15182
Publisher
MDPI AG
Online
2022-12-05
DOI
10.3390/ijms232315182
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Note: Only part of the references are listed.- Control of STING Agonistic/Antagonistic Activity Using Amine-Skeleton-Based c-di-GMP Analogues
- (2022) Yuta Yanase et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Aging and age‐related diseases: from mechanisms to therapeutic strategies
- (2021) Zhe Li et al. BIOGERONTOLOGY
- STING inhibitors target the cyclic dinucleotide binding pocket
- (2021) Ze Hong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Role of Immune Cells in Oxi-Inflamm-Aging
- (2021) Irene Martínez de Toda et al. Cells
- Structural Insights into STING Signaling
- (2020) Sabrina L. Ergun et al. TRENDS IN CELL BIOLOGY
- Molecular mechanisms and cellular functions of cGAS–STING signalling
- (2020) Karl-Peter Hopfner et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
- (2020) Helmut Sies et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
- (2020) Katherine R. Balka et al. Cell Reports
- Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
- (2020) Dongshan Wan et al. Frontiers in Immunology
- Redox homeostasis maintained by GPX4 facilitates STING activation
- (2020) Mutian Jia et al. NATURE IMMUNOLOGY
- Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases
- (2020) Mehdi Sharifi-Rad et al. Frontiers in Physiology
- Reactive oxygen species oxidize STING and suppress interferon production
- (2020) Lili Tao et al. eLife
- Development of small molecule inhibitors/agonists targeting STING for disease
- (2020) Kaifeng Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus
- (2019) Matteo Gentili et al. Cell Reports
- Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3
- (2019) Xiaohan Ning et al. MOLECULAR CELL
- Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression
- (2019) Arshed Nazmi et al. GLIA
- Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity
- (2019) Jiang Dai et al. CELL
- Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA
- (2019) Katherine C. Barnett et al. CELL
- Advantages and disadvantages of apoptosis in the aging process
- (2019) Sandro Argüelles et al. Annals of the New York Academy of Sciences
- The senescence-associated secretory phenotype and its regulation
- (2019) Stéphane Lopes-Paciencia et al. CYTOKINE
- SLC19A1 Is an Importer of the Immunotransmitter cGAMP
- (2019) Christopher Ritchie et al. MOLECULAR CELL
- Cellular Senescence: Aging, Cancer, and Injury
- (2019) Arianna Calcinotto et al. PHYSIOLOGICAL REVIEWS
- Telomeres and Longevity: A Cause or an Effect?
- (2019) Huda Adwan Shekhidem et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- From discoveries in ageing research to therapeutics for healthy ageing
- (2019) Judith Campisi et al. NATURE
- Adaptation and memory in immune responses
- (2019) Gioacchino Natoli et al. NATURE IMMUNOLOGY
- DNA sensing by the cGAS–STING pathway in health and disease
- (2019) Mona Motwani et al. NATURE REVIEWS GENETICS
- Interferon-Stimulated Genes: What Do They All Do?
- (2019) John W. Schoggins Annual Review of Virology
- Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
- (2019) Hui Jiang et al. EMBO JOURNAL
- Self-DNA Sensing in Lung Inflammatory Diseases
- (2019) Sulayman Benmerzoug et al. TRENDS IN IMMUNOLOGY
- Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonists
- (2019) Shi Hou et al. BIOORGANIC CHEMISTRY
- Cellular senescence and senescence‐associated secretory phenotype via the cGAS‐STING signaling pathway in cancer
- (2019) Tze Mun Loo et al. CANCER SCIENCE
- DNA Oxidation and Excision Repair Pathways
- (2019) Tae-Hee Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- lncRNA-Triggered Macrophage Inflammaging Deteriorates Age-Related Diseases
- (2019) Lulingxiao Nie et al. MEDIATORS OF INFLAMMATION
- Regulation of cGAS- and RLR-mediated immunity to nucleic acids
- (2019) Andrea Ablasser et al. NATURE IMMUNOLOGY
- Nuclear Genomic Instability and Aging
- (2018) Laura J. Niedernhofer et al. Annual Review of Biochemistry
- The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
- (2018) Tuo Li et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Innate immunity and tolerance toward mitochondria
- (2018) Anthony Rongvaux MITOCHONDRION
- Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
- (2018) Akiko Takahashi et al. Nature Communications
- Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
- (2018) Daniel Torralba et al. Nature Communications
- Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
- (2018) Irene Maeve Rea et al. Frontiers in Immunology
- Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction
- (2018) Yukun Zhu et al. BIOGERONTOLOGY
- Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
- (2018) Gillian Dunphy et al. MOLECULAR CELL
- Parkin and PINK1 mitigate STING-induced inflammation
- (2018) Danielle A. Sliter et al. NATURE
- Inflammaging: a new immune–metabolic viewpoint for age-related diseases
- (2018) Claudio Franceschi et al. Nature Reviews Endocrinology
- Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
- (2018) David Olagnier et al. Nature Communications
- The Dual Nature of Type I and Type II Interferons
- (2018) Amanda J. Lee et al. Frontiers in Immunology
- Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
- (2018) Haipeng Liu et al. NATURE
- The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
- (2018) Sonal Srikanth et al. NATURE IMMUNOLOGY
- Inflammaging 2018: An update and a model
- (2018) Claudio Franceschi et al. SEMINARS IN IMMUNOLOGY
- The integration of inflammaging in age-related diseases
- (2018) Tamas Fulop et al. SEMINARS IN IMMUNOLOGY
- Impaired immune surveillance accelerates accumulation of senescent cells and aging
- (2018) Yossi Ovadya et al. Nature Communications
- Mitochondria, Oxidative Stress and Innate Immunity
- (2018) Yuxin Chen et al. Frontiers in Physiology
- Healthy aging: A bibliometric analysis of the literature
- (2018) Yao-Hua Gu et al. EXPERIMENTAL GERONTOLOGY
- DNA damage related crosstalk between the nucleus and mitochondria
- (2017) Mohammad Saki et al. FREE RADICAL BIOLOGY AND MEDICINE
- Interferon-Stimulated Genes as Enhancers of Antiviral Innate Immune Signaling
- (2017) Keaton M. Crosse et al. Journal of Innate Immunity
- Immune Diseases Associated with TREX1 and STING Dysfunction
- (2017) Nan Yan JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- A novel non-contact communication between human keratinocytes and T cells: Exosomes derived from keratinocytes support superantigen-induced proliferation of resting T cells
- (2017) Xiao-Wei Cai et al. Molecular Medicine Reports
- cGAS surveillance of micronuclei links genome instability to innate immunity
- (2017) Karen J. Mackenzie et al. NATURE
- Cytoplasmic chromatin triggers inflammation in senescence and cancer
- (2017) Zhixun Dou et al. NATURE
- Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
- (2017) Selene Glück et al. NATURE CELL BIOLOGY
- cGAS is essential for cellular senescence
- (2017) Hui Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inflammaging and ‘Garb-aging’
- (2017) Claudio Franceschi et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Redox control of senescence and age-related disease
- (2017) Akshaya Chandrasekaran et al. Redox Biology
- Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection
- (2017) Sebastian Aguirre et al. Nature Microbiology
- Aging impairs double-strand break repair by homologous recombination in Drosophila germ cells
- (2016) Laetitia Delabaere et al. AGING CELL
- Regulatory principles in metabolism-then and now
- (2016) R. Curi et al. BIOCHEMICAL JOURNAL
- Recognition of Endogenous Nucleic Acids by the Innate Immune System
- (2016) Axel Roers et al. IMMUNITY
- cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling
- (2016) Jianli Tao et al. IUBMB LIFE
- The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence
- (2016) Moisés Evandro Bauer et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Out with the old
- (2016) Jesús Gil et al. NATURE
- Repair Pathway Choices and Consequences at the Double-Strand Break
- (2016) Raphael Ceccaldi et al. TRENDS IN CELL BIOLOGY
- Activation of STING requires palmitoylation at the Golgi
- (2016) Kojiro Mukai et al. Nature Communications
- DNA sensor cGAS-mediated immune recognition
- (2016) Pengyan Xia et al. Protein & Cell
- From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation
- (2015) T. Fulop et al. BIOGERONTOLOGY
- Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health
- (2015) James P. Kehrer et al. CRITICAL REVIEWS IN TOXICOLOGY
- The role of antioxidants in the chemistry of oxidative stress: A review
- (2015) Aurelia Magdalena Pisoschi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Mitochondrial DNA stress primes the antiviral innate immune response
- (2015) A. Phillip West et al. NATURE
- A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis
- (2015) Bappaditya Dey et al. NATURE MEDICINE
- HSC Aging and Senescent Immune Remodeling
- (2015) Michael D. Denkinger et al. TRENDS IN IMMUNOLOGY
- Cell Therapy Strategies to Combat Immunosenescence
- (2015) Elizabeth C Stahl et al. Organogenesis
- DNA Damage, DNA Repair, Aging, and Neurodegeneration
- (2015) Scott Maynard et al. Cold Spring Harbor Perspectives in Medicine
- Labeling of Oxidizable Proteins with a Photoactivatable Analog of the Antitumor Agent DMXAA: Evidence for Redox Signaling in Its Mode of Action
- (2015) Romy Brauer et al. NEOPLASIA
- Interferon-Stimulated Genes: A Complex Web of Host Defenses
- (2014) William M. Schneider et al. Annual Review of Immunology
- Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
- (2014) Jiaxi Wu et al. Annual Review of Immunology
- The Influence of the Occupational Exposure to Heavy Metals and Tobacco Smoke on the Selected Oxidative Stress Markers in Smelters
- (2014) Milena Ściskalska et al. BIOLOGICAL TRACE ELEMENT RESEARCH
- Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
- (2014) Anthony Rongvaux et al. CELL
- Geroscience: Linking Aging to Chronic Disease
- (2014) Brian K. Kennedy et al. CELL
- Free radicals, reactive oxygen species, oxidative stress and its classification
- (2014) Volodymyr I. Lushchak CHEMICO-BIOLOGICAL INTERACTIONS
- Senescence and apoptosis: dueling or complementary cell fates?
- (2014) B. G. Childs et al. EMBO REPORTS
- Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1
- (2014) T. Abe et al. JOURNAL OF VIROLOGY
- Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
- (2014) C. Franceschi et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling
- (2014) Xin Cai et al. MOLECULAR CELL
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
- Cellular senescence: from physiology to pathology
- (2014) Daniel Muñoz-Espín et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy
- (2014) Yuk Yuen Lan et al. Cell Reports
- Genome Instability and Aging
- (2013) Jan Vijg et al. Annual Review of Physiology
- Ionizing Radiation-Induced Responses: Where Free Radical Chemistry Meets Redox Biology and Medicine
- (2013) Douglas R. Spitz et al. ANTIOXIDANTS & REDOX SIGNALING
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
- (2013) Xin Li et al. IMMUNITY
- Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing
- (2013) Nadine Gehrke et al. IMMUNITY
- Immune Sensing of DNA
- (2013) Søren R. Paludan et al. IMMUNITY
- Reactive Oxygen Species in the Immune System
- (2013) Yuhui Yang et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
- (2013) J. Conlon et al. JOURNAL OF IMMUNOLOGY
- Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
- (2013) Xu Zhang et al. MOLECULAR CELL
- Structural mechanism of cytosolic DNA sensing by cGAS
- (2013) Filiz Civril et al. NATURE
- Understanding immunosenescence to improve responses to vaccines
- (2013) Jörg J Goronzy et al. NATURE IMMUNOLOGY
- Oxidative stress and the ageing endocrine system
- (2013) Giovanni Vitale et al. Nature Reviews Endocrinology
- Role of Reactive Oxygen Species-Mediated Signaling in Aging
- (2012) Vyacheslav M. Labunskyy et al. ANTIOXIDANTS & REDOX SIGNALING
- Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases
- (2012) I-Ta Lee et al. BIOCHEMICAL PHARMACOLOGY
- Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome
- (2012) Monika Fleshner BRAIN BEHAVIOR AND IMMUNITY
- Reactive Oxygen Species in Health and Disease
- (2012) Assim A. Alfadda et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- NF-κB inhibition delays DNA damage–induced senescence and aging in mice
- (2012) Jeremy S. Tilstra et al. JOURNAL OF CLINICAL INVESTIGATION
- Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
- (2012) Chang Shu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- Nucleic Acid Recognition by the Innate Immune System
- (2011) Roman Barbalat et al. Annual Review of Immunology
- Inflamm-aging of the stem cell niche: Breast cancer as a paradigmatic example
- (2011) Massimiliano Bonafè et al. BIOESSAYS
- Cross talk between mitochondria and NADPH oxidases
- (2011) Sergey Dikalov FREE RADICAL BIOLOGY AND MEDICINE
- Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity
- (2011) Y. Chien et al. GENES & DEVELOPMENT
- Measuring Genome Instability in Aging – A Mini-Review
- (2011) Wenge Li et al. GERONTOLOGY
- Four faces of cellular senescence
- (2011) Francis Rodier et al. JOURNAL OF CELL BIOLOGY
- MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP
- (2011) L. Jin et al. JOURNAL OF IMMUNOLOGY
- Oxidative stress, inflamm-aging and immunosenescence
- (2011) Elvira S. Cannizzo et al. Journal of Proteomics
- STING is a direct innate immune sensor of cyclic di-GMP
- (2011) Dara L. Burdette et al. NATURE
- Innate and adaptive immunosenescence
- (2010) Shradha Agarwal et al. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Aging and Immune Function: Molecular Mechanisms to Interventions
- (2010) Subramaniam Ponnappan et al. ANTIOXIDANTS & REDOX SIGNALING
- Base Excision Repair and Lesion-Dependent Subpathways for Repair of Oxidative DNA Damage
- (2010) David Svilar et al. ANTIOXIDANTS & REDOX SIGNALING
- The essence of senescence
- (2010) T. Kuilman et al. GENES & DEVELOPMENT
- The Aging Stress Response
- (2010) Marcia C. Haigis et al. MOLECULAR CELL
- Feedback between p21 and reactive oxygen production is necessary for cell senescence
- (2010) João F Passos et al. Molecular Systems Biology
- Cellular senescence: unravelling complexity
- (2009) João F. Passos et al. AGE
- An Update of the Oxidation-Inflammation Theory of Aging: The Involvement of the Immune System in Oxi-Inflamm-Aging
- (2009) Monica Fuente et al. CURRENT PHARMACEUTICAL DESIGN
- Is there more to aging than mitochondrial DNA and reactive oxygen species?
- (2009) Mikhail F. Alexeyev FEBS Journal
- Senescence of Cultured Porcine Coronary Arterial Endothelial Cells Is Associated with Accelerated Oxidative Stress and Activation of NFĸB
- (2009) Mary Y.K. Lee et al. JOURNAL OF VASCULAR RESEARCH
- Reactive oxygen intermediate-induced pathomechanisms contribute to immunosenescence, chronic inflammation and autoimmunity
- (2009) Thorsten Peters et al. MECHANISMS OF AGEING AND DEVELOPMENT
- The inflammatory status of the elderly: The intestinal contribution
- (2009) Eduardo J. Schiffrin et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- The DNA-damage response in human biology and disease
- (2009) Stephen P. Jackson et al. NATURE
- Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
- (2009) Francis Rodier et al. NATURE CELL BIOLOGY
- DNA Damage, Aging, and Cancer
- (2009) Jan H.J. Hoeijmakers NEW ENGLAND JOURNAL OF MEDICINE
- Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence
- (2009) P. Rai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
- (2009) W. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
- (2008) Thomas Kuilman et al. CELL
- Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
- (2008) Juan C. Acosta et al. CELL
- Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity
- (2008) Daniel B. Stetson et al. CELL
- Free radicals and senescence
- (2008) Teng Lu et al. EXPERIMENTAL CELL RESEARCH
- MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals
- (2008) L. Jin et al. MOLECULAR AND CELLULAR BIOLOGY
- Origin and physiological roles of inflammation
- (2008) Ruslan Medzhitov NATURE
- The immune system in extreme longevity
- (2007) P. Sansoni et al. EXPERIMENTAL GERONTOLOGY
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