Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury

(2018) Amar Abdullah et al.   Journal of Neuroinflammation

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

Type-1 interferons contribute to the neuroinflammatory response and disease progression of the MPTP mouse model of Parkinson's disease

(2016) Bevan S. Main et al.   GLIA

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

(2016) Elizabeth. C. Carroll et al.   IMMUNITY

Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment

(2016) Thomas Blank et al.   IMMUNITY

Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes

(2016) Arvin Iracheta-Vellve et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation

(2016) Gerben Marsman et al.   Cell Death & Disease

Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype

(2016) Myles R. Minter et al.   Acta Neuropathologica Communications

Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis

(2015) Reza Khorooshi et al.   ACTA NEUROPATHOLOGICA

The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s disease

(2015) Sandro Dá Mesquita et al.   BRAIN BEHAVIOR AND IMMUNITY

Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C

(2015) Carol Murray et al.   BRAIN BEHAVIOR AND IMMUNITY

Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia

(2015) Patrick Ejlerskov et al.   CELL

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

DNA sensors are expressed in astrocytes and microgliain vitroand are upregulated during gliosis in neurodegenerative disease

(2015) Donal J. Cox et al.   GLIA

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei

(2015) Renata Reis et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Interferons and viruses: an evolutionary arms race of molecular interactions

(2015) Hans-Heinrich Hoffmann et al.   TRENDS IN IMMUNOLOGY

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models

(2014) Jenny U. Johansson et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

(2014) L.-G. Bodea et al.   JOURNAL OF NEUROSCIENCE

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Interferons in the central nervous system: A few instruments play many tunes

(2013) Trevor Owens et al.   GLIA

Type I IFN Inhibits Innate IL-10 Production in Macrophages through Histone Deacetylase 11 by Downregulating MicroRNA-145

(2013) L. Lin et al.   JOURNAL OF IMMUNOLOGY

Cyclooxygenase-1-Dependent Prostaglandins Mediate Susceptibility to Systemic Inflammation-Induced Acute Cognitive Dysfunction

(2013) E. W. Griffin et al.   JOURNAL OF NEUROSCIENCE

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1

(2013) Nicole A de Weerd et al.   NATURE IMMUNOLOGY

Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease

(2013) Juliet M. Taylor et al.   NEUROBIOLOGY OF AGING

Role of PGE2 EP1 Receptor in Intracerebral Hemorrhage-Induced Brain Injury

(2013) Nilendra Singh et al.   NEUROTOXICITY RESEARCH

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

Toll/Interleukin-1 Receptor Domain-Containing Adapter Inducing Interferon-  Mediates Microglial Phagocytosis of Degenerating Axons

(2012) S. Hosmane et al.   JOURNAL OF NEUROSCIENCE

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

(2012) Julie A. Moreno et al.   NATURE

Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse model

(2011) Rengang Wang et al.   GLIA

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

(2011) J. J. Neher et al.   JOURNAL OF IMMUNOLOGY

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

Morphological and Functional Abnormalities in Mitochondria Associated with Synaptic Degeneration in Prion Disease

(2010) Zuzana Sisková et al.   AMERICAN JOURNAL OF PATHOLOGY

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration

(2010) Robert Field et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation

(2010) Martina M. Hughes et al.   GLIA

Injury-Induced Type I IFN Signaling Regulates Inflammatory Responses in the Central Nervous System

(2010) R. Khorooshi et al.   JOURNAL OF IMMUNOLOGY

Novel Reporter Mouse Reveals Constitutive and Inflammatory Expression of IFN-  In Vivo

(2009) S. Lienenklaus et al.   JOURNAL OF IMMUNOLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Selective presynaptic degeneration in the synaptopathy associated with ME7-induced hippocampal pathology

(2009) Bryony C. Gray et al.   NEUROBIOLOGY OF DISEASE

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

(2008) Marco Prinz et al.   IMMUNITY

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

(2007) Karine Palin et al.   NEUROBIOLOGY OF DISEASE