Inflamm-aging of the stem cell niche: Breast cancer as a paradigmatic example

Aging-Associated Changes in Hematopoiesis and Leukemogenesis: What's the Connection?

(2016) Curtis J. Henry et al.   Aging-US

A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers

(2015)   Oncotarget

Radiation Induced Non-targeted Response: Mechanism and Potential Clinical Implications

(2012) Tom K. Hei et al.   Current Molecular Pharmacology

Ageing of the human metaorganism: the microbial counterpart

(2011) Elena Biagi et al.   AGE

The aging gut microbiota: New perspectives

(2011) Elena Biagi et al.   AGEING RESEARCH REVIEWS

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment

(2011) Ning Li et al.   CANCER CELL

CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

(2011) Jingqi Chen et al.   CANCER CELL

HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis

(2011) Z. C. Hartman et al.   CANCER RESEARCH

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

(2011) B. Dirat et al.   CANCER RESEARCH

Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues

(2011) Benjamin D. Simons et al.   CELL

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

Regulation of Cancer Stem Cells by Cytokine Networks: Attacking Cancer's Inflammatory Roots

(2011) H. Korkaya et al.   CLINICAL CANCER RESEARCH

Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?

(2011) Carolien M Woolthuis et al.   CURRENT OPINION IN IMMUNOLOGY

Inflammation and mesenchymal stem cell aging

(2011) Günter Lepperdinger   CURRENT OPINION IN IMMUNOLOGY

Methylome analysis reveals Jak-STAT pathway deregulation in putative breast cancer stem cells

(2011) Héctor Hernández-Vargas et al.   Epigenetics

GLI2 Transcription Factor Mediates Cytokine Cross-talk in the Tumor Microenvironment

(2011) Sherine F. Elsawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

(2011) Simon A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in

(2011) Armin Ehninger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cytokine signalling in mammary gland development

(2011) Christine J. Watson et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Interleukin-6, C-Reactive Protein, and Tumor Necrosis Factor-Alpha as Predictors of Mortality in Frail, Community-Living Elderly Individuals

(2011) Silvia Giovannini et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2

(2011) Traci R Lyons et al.   NATURE MEDICINE

Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging

(2011) Claudia E. Rübe et al.   PLoS One

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Aging, frailty and age-related diseases

(2010) T. Fulop et al.   BIOGERONTOLOGY

Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome

(2010) Michael J. Campbell et al.   BREAST CANCER RESEARCH AND TREATMENT

p53 Status in Stromal Fibroblasts Modulates Tumor Growth in an SDF1-Dependent Manner

(2010) Y. Addadi et al.   CANCER RESEARCH

The Canonical NF- B Pathway Governs Mammary Tumorigenesis in Transgenic Mice and Tumor Stem Cell Expansion

(2010) M. Liu et al.   CANCER RESEARCH

DNA Damage-Mediated Induction of a Chemoresistant Niche

(2010) Luke A. Gilbert et al.   CELL

BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

(2010) Gemma Molyneux et al.   Cell Stem Cell

Radiation-induced bystander signaling pathways in human fibroblasts: A role for interleukin-33 in the signal transmission

(2010) Vladimir N. Ivanov et al.   CELLULAR SIGNALLING

Stem cell regulatory niches and their role in normal and malignant hematopoiesis

(2010) Nadia Carlesso et al.   CURRENT OPINION IN HEMATOLOGY

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype

(2010) Gianluca Storci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Jekyll and Hyde: the role of the microenvironment on the progression of cancer

(2010) Michael Allen et al.   JOURNAL OF PATHOLOGY

Genetic changes in tumour microenvironments

(2010) Ian Campbell et al.   JOURNAL OF PATHOLOGY

Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells

(2010) Laura D'Anello et al.   Molecular Cancer

Medium-mediated DNA repair response after ionizing radiation is correlated with the increase of specific cytokines in human fibroblasts

(2010) Birger Dieriks et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

(2010) Elena Biagi et al.   PLoS One

Radiation-Induced Delayed Bystander-Type Effects Mediated by Hemopoietic Cells

(2010) Karen L. Burr et al.   RADIATION RESEARCH

Mutations in Bone Marrow-Derived Stromal Stem Cells Unmask Latent Malignancy

(2010) JeanMarie Houghton et al.   STEM CELLS AND DEVELOPMENT

Genomic Alterations in Tumor Stroma

(2009) C. Eng et al.   CANCER RESEARCH

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

(2009) Yohei Shimono et al.   CELL

Mechanisms of hematopoietic stem cell aging

(2009) Aysegul V. Ergen et al.   EXPERIMENTAL GERONTOLOGY

The canonical NF-κB pathway is required for formation of luminal mammary neoplasias and is activated in the mammary progenitor population

(2009) M A C Pratt et al.   ONCOGENE

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells

(2009) M Walter et al.   ONCOGENE

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

(2009) Binzhi Qian et al.   PLoS One

Human Papillomaviruses Activate the ATM DNA Damage Pathway for Viral Genome Amplification upon Differentiation

(2009) Cary A. Moody et al.   PLoS Pathogens

Inflammation and cancer: The oncogene-driven connection

(2008) Maria Grazia Borrello et al.   CANCER LETTERS

Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6–Dependent Manner

(2008) Adam W. Studebaker et al.   CANCER RESEARCH

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

(2008) Keith W. Orford et al.   NATURE REVIEWS GENETICS