Metformin and Its Immune-Mediated Effects in Various Diseases

Metformin ameliorates chronic colitis in a mouse model by regulating interferon‐γ‐producing lamina propria CD4 + T cells through AMPK activation

(2022) Masahiro Takahara et al.   FASEB JOURNAL

Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model

(2022) Mineyuki Tojo et al.   Scientific Reports

Dual Effect of Combined Metformin and 2-Deoxy-D-Glucose Treatment on Mitochondrial Biogenesis and PD-L1 Expression in Triple-Negative Breast Cancer Cells

(2022) Jernej Repas et al.   Cancers

Bacteria-mediated metformin-loaded peptide hydrogel reprograms the tumor immune microenvironment in glioblastoma

(2022) Lisheng Zhu et al.   BIOMATERIALS

Metformin modulate immune fitness in hepatocellular carcinoma: Molecular and cellular approach

(2022) Eslam E. Abd El-Fattah et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Super-Resolution Quantification of T2DM-Induced Mitochondrial Morphology Changes and Their Implications in Pharmacodynamics of Metformin and Sorafenib

(2022) Yang Du et al.   Frontiers in Pharmacology

Nutrient Condition in the Microenvironment Determines Essential Metabolisms of CD8+ T Cells for Enhanced IFNγ Production by Metformin

(2022) Ruoyu Chao et al.   Frontiers in Immunology

Metabolic Action of Metformin

(2022) Izabela Szymczak-Pajor et al.   Pharmaceuticals

Metformin modified chitosan as a multi-functional adjuvant to enhance cisplatin-based tumor chemotherapy efficacy

(2022) Zaigang Zhou et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice

(2022) David A. Landry et al.   Science Advances

Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition

(2022) McKenzie Crist et al.   Journal for ImmunoTherapy of Cancer

Metformin Mediated PD‐L1 Downregulation in Combination with Photodynamic‐Immunotherapy for Treatment of Breast Cancer

(2021) Chuan Hu et al.   ADVANCED FUNCTIONAL MATERIALS

Targeting age‐specific changes in CD4 + T cell metabolism ameliorates alloimmune responses and prolongs graft survival

(2021) Yeqi Nian et al.   AGING CELL

Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma

(2021) Yimin Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles

(2021) Zhaohan Wei et al.   Nature Communications

Metformin Liposome-Mediated PD-L1 Downregulation for Amplifying the Photodynamic Immunotherapy Efficacy

(2021) Wei Xiong et al.   ACS Applied Materials & Interfaces

LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy

(2021) Delphine Planas et al.   EBioMedicine

Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication

(2021) Haitao Guo et al.   NATURE IMMUNOLOGY

Melatonin and Metformin Failed to Modify the Effect of Dacarbazine in Melanoma

(2021) Aleksei Viktorovich Novik et al.   ONCOLOGIST

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

(2021) Hongxu Xian et al.   IMMUNITY

PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain

(2021) Maorong Wen et al.   Nature Communications

Metformin Reverses Hashimoto’s Thyroiditis by Regulating Key Immune Events

(2021) Xi Jia et al.   Frontiers in Cell and Developmental Biology

Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin

(2021) Shaomeng Chen et al.   Biomolecules

Chitosan oligosaccharide regulates AMPK and STAT1 pathways synergistically to mediate PD-L1 expression for cancer chemoimmunotherapy

(2021) Jiashe Chen et al.   CARBOHYDRATE POLYMERS

Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro

(2021) Nuria Pescador et al.   Redox Biology

Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy

(2021) Luis Enrique Munoz et al.   Journal for ImmunoTherapy of Cancer

Metformin: An old drug against old age and associated morbidities

(2020) Teresa Salvatore et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

(2020) Leena P. Bharath et al.   Cell Metabolism

Metformin Enhances the Antitumor Activity of CD8+ T Lymphocytes via the AMPK–miR-107–Eomes–PD-1 Pathway

(2020) Zhen Zhang et al.   JOURNAL OF IMMUNOLOGY

Low-Dose Metformin Reprograms the Tumor Immune Microenvironment in Human Esophageal Cancer: Results of a Phase II Clinical Trial

(2020) Shuhong Wang et al.   CLINICAL CANCER RESEARCH

Enhanced Release of Glucose Into the Intraluminal Space of the Intestine Associated With Metformin Treatment as Revealed by [18F]Fluorodeoxyglucose PET-MRI

(2020) Yasuko Morita et al.   DIABETES CARE

Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4+ T Cell Effector Functions and Activation-Induced Metabolic Reprogramming

(2020) Stefanie Y. Tan et al.   JOURNAL OF IMMUNOLOGY

Metformin and risk of cancer among patients with type 2 diabetes mellitus: A systematic review and meta-analysis

(2020) Kui Zhang et al.   Primary Care Diabetes

The Causal Role of Mitochondrial Dynamics in Regulating Innate Immunity in Diabetes

(2020) Yen-Hsiang Chang et al.   Frontiers in Endocrinology

Repurposing metformin in non-diabetic people living with HIV: Influence on weight and gut microbiota

(2020) Stéphane Isnard et al.   Open Forum Infectious Diseases

Effects of Brief Adjunctive Metformin Therapy in Virologically Suppressed HIV-Infected Adults on Polyfunctional HIV-Specific CD8 T cell Responses to PD-L1 Blockade

(2020) Glen Chew et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Metformin changes the immune microenvironment of colorectal cancer in patients with type 2 diabetes mellitus

(2020) Akira Saito et al.   CANCER SCIENCE

Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis

(2020) Ichiro Nojima et al.   Scientific Reports

Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects?

(2020) Teresa Salvatore et al.   Biomedicines

Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol

(2019) Jean-Pierre Routy et al.   BMJ Open

Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells

(2019) Anton A. Titov et al.   JOURNAL OF IMMUNOLOGY

Metformin Reduces CD4 T-Cell Exhaustion in HIV-Infected Adults on Suppressive Antiretroviral Therapy

(2019) Cecilia Shikuma et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Metformin Abrogates Age-Associated Ovarian Fibrosis

(2019) Curtis W. McCloskey et al.   CLINICAL CANCER RESEARCH

Metformin effects on FOXP3 + and CD8 + T cell infiltrates of head and neck squamous cell carcinoma

(2019) Dev Amin et al.   LARYNGOSCOPE

Metformin attenuates bleomycin-induced scleroderma by regulating the balance of Treg/Teff cells and reducing spleen germinal center formation

(2019) Yanlin Wang et al.   MOLECULAR IMMUNOLOGY

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

Metformin Suppresses Systemic Autoimmunity inRoquinsan/sanMice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3

(2017) Seon-Yeong Lee et al.   JOURNAL OF IMMUNOLOGY

Attenuation of CD4 + CD25 + Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

(2017) Yuki Kunisada et al.   EBioMedicine

Mitochondria-associated membranes as hubs for neurodegeneration

(2016) Michiel Krols et al.   ACTA NEUROPATHOLOGICA

Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin

(2016) Sameer S. Kulkarni et al.   DIABETES

Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice

(2016) Yafei Sun et al.   JOURNAL OF NEUROIMMUNOLOGY

Erratum: Corrigendum: Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats

(2016) Frank A Duca et al.   NATURE MEDICINE

Metformin attenuates graft-versus-host disease via restricting mammalian target of rapamycin/signal transducer and activator of transcription 3 and promoting adenosine monophosphate–activated protein kinase-autophagy for the balance between T helper 17 and Tregs

(2016) Min-Jung Park et al.   Translational Research

Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis

(2016) Laura Negrotto et al.   JAMA Neurology

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Glucose Oxidation Is Critical for CD4+T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus

(2015) Yiming Yin et al.   JOURNAL OF IMMUNOLOGY

Immune-mediated antitumor effect by type 2 diabetes drug, metformin

(2015) Shingo Eikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

New mechanisms of metformin action: Focusing on mitochondria and the gut

(2015) Kyu Yeon Hur et al.   Journal of Diabetes Investigation

Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof-of-Concept Trial of Metformin

(2015) Haiting Wang et al.   Arthritis & Rheumatology

Metformin aggravates immune-mediated liver injury in mice

(2014) Vladislav Volarevic et al.   ARCHIVES OF TOXICOLOGY

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Metformin, cancer and glucose metabolism

(2014) Barbara Salani et al.   ENDOCRINE-RELATED CANCER

Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma

(2014) Dong Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

The Target of Metformin in Type 2 Diabetes

(2014) Ele Ferrannini   NEW ENGLAND JOURNAL OF MEDICINE

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Metformin downregulates Th17 cells differentiation and attenuates murine autoimmune arthritis

(2013) Kwi Young Kang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II

(2013) Barbara Salani et al.   Scientific Reports

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Relevance of the OCT1 transporter to the antineoplastic effect of biguanides

(2011) Eric D. Segal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion

(2009) Zhiyin Song et al.   MOLECULAR BIOLOGY OF THE CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE