Metformin modified chitosan as a multi-functional adjuvant to enhance cisplatin-based tumor chemotherapy efficacy

Metformin Mediated PD‐L1 Downregulation in Combination with Photodynamic‐Immunotherapy for Treatment of Breast Cancer

(2021) Chuan Hu et al.   ADVANCED FUNCTIONAL MATERIALS

Metformin Liposome-Mediated PD-L1 Downregulation for Amplifying the Photodynamic Immunotherapy Efficacy

(2021) Wei Xiong et al.   ACS Applied Materials & Interfaces

Graphene oxide (GO)-based nanosheets with combined chemo/photothermal/photodynamic therapy to overcome gastric cancer (GC) paclitaxel resistance by reducing mitochondria-derived adenosine-triphosphate (ATP)

(2021) Weihong Guo et al.   JOURNAL OF NANOBIOTECHNOLOGY

Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion

(2021) Yan Lan et al.   CANCER CELL

Tumor microenvironment triggered local oxygen generation and photosensitizer release from manganese dioxide mineralized albumin-ICG nanocomplex to amplify photodynamic immunotherapy efficacy

(2021) Ning Jiang et al.   CHINESE CHEMICAL LETTERS

A dual-functional chitosan derivative platform for fungal keratitis

(2021) Liuqi Shi et al.   CARBOHYDRATE POLYMERS

Bioactive chitosan biguanidine-based injectable hydrogels as a novel BMP-2 and VEGF carrier for osteogenesis of dental pulp stem cells

(2021) Baharak Divband et al.   CARBOHYDRATE POLYMERS

Chitosan oligosaccharide regulates AMPK and STAT1 pathways synergistically to mediate PD-L1 expression for cancer chemoimmunotherapy

(2021) Jiashe Chen et al.   CARBOHYDRATE POLYMERS

Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy

(2021) Zaigang Zhou et al.   JOURNAL OF NANOBIOTECHNOLOGY

In vitro/vivo evaluation of novel mitochondrial targeting charge-reversal polysaccharide-based antitumor nanoparticle

(2020) Lei Fang et al.   CARBOHYDRATE POLYMERS

Chitosan: A compound for drug delivery system in gastric cancer-a review

(2020) Rana Shafabakhsh et al.   CARBOHYDRATE POLYMERS

Synthesis and antimicrobial properties of new chitosan derivatives containing guanidinium groups

(2020) Ahmed Salama et al.   CARBOHYDRATE POLYMERS

PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer

(2020) Wendan Yu et al.   Cell Death & Disease

Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer

(2020) Wataru Ishikawa et al.   Molecular Therapy-Oncolytics

Combination of radiotherapy and suppression of Tregs enhances abscopal antitumor effect and inhibits metastasis in rectal cancer

(2020) Dengbo Ji et al.   Journal for ImmunoTherapy of Cancer

Development of mucoadhesive hydrogels based on polyacrylic acid grafted cellulose nanocrystals for local cisplatin delivery

(2020) Mohammad Reza Vakili et al.   CARBOHYDRATE POLYMERS

Targeted Interleukin-22 Gene Delivery in the Liver by Poly-Metformin and Penetratin-Based Hybrid Nanoparticles to Treat Non-Alcoholic Fatty Liver Disease

(2019) Wenjing Zai et al.   ACS Applied Materials & Interfaces

Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway

(2019) Mingjing Shen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

(2019) Xinyi Tu et al.   MOLECULAR CELL

Perfluorocarbon nanoparticle-mediated platelet inhibition promotes intratumoral infiltration of T cells and boosts immunotherapy

(2019) Zaigang Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cisplatin: The first metal based anticancer drug

(2019) Sumit Ghosh   BIOORGANIC CHEMISTRY

New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment

(2019) Shang-Hung Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Carboxymethyl cellulose/sodium alginate/chitosan biguanidine hydrochloride ternary system for edible coatings

(2019) Hend E. Salama et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The crosstalk between STAT3 and p53/RAS signaling controls cancer cell metastasis and cisplatin resistance via the Slug/MAPK/PI3K/AKT-mediated regulation of EMT and autophagy

(2019) Fan Liang et al.   Oncogenesis

Cisplatin‐mediated down‐regulation of miR‐145 contributes to up‐regulation of PD‐L1 via the c‐Myc transcription factor in cisplatin‐resistant ovarian carcinoma cells

(2019) Q. Sheng et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Development and evaluation of novel biodegradable chitosan based metformin intrapocket dental film for the management of periodontitis and alveolar bone loss in a rat model

(2018) Deepak Kumar Khajuria et al.   ARCHIVES OF ORAL BIOLOGY

Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

(2018) Wantong Song et al.   Nature Communications

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

(2018) Lu Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Perfluorocarbon Nanoparticles Mediated Platelet Blocking Disrupt Vascular Barriers to Improve the Efficacy of Oxygen-Sensitive Antitumor Drugs

(2018) Zaigang Zhou et al.   Small

Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy

(2018) Jinfang Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phytochemicals: Current strategy to sensitize cancer cells to cisplatin

(2018) Chao-Yue Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells

(2017) Hiro Sato et al.   Nature Communications

Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells

(2017) Sung-Hee Kim et al.   Oncotarget

Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells

(2016) Gang Cheng et al.   CANCER RESEARCH

Synthesis, characterization, and biological activity of cross-linked chitosan biguanidine loaded with silver nanoparticles

(2016) Hend E. Salama et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Biocompatible polymeric nanocomplexes as an intracellular stimuli-sensitive prodrug for type-2 diabetes combination therapy

(2015) Feng-Zhen Wang et al.   BIOMATERIALS

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation

(2010) Hyung Gyun Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY