Chitosan oligosaccharide regulates AMPK and STAT1 pathways synergistically to mediate PD-L1 expression for cancer chemoimmunotherapy

Chitooligosaccharides inhibit tumor progression and induce autophagy through the activation of the p53/mTOR pathway in osteosarcoma

(2021) Zhen Pan et al.   CARBOHYDRATE POLYMERS

Metformin Liposome-Mediated PD-L1 Downregulation for Amplifying the Photodynamic Immunotherapy Efficacy

(2021) Wei Xiong et al.   ACS Applied Materials & Interfaces

Paradigms on Immunotherapy Combinations with Chemotherapy

(2021) Diego Salas-Benito et al.   Cancer Discovery

Lepidium meyenii Walpers Polysaccharide and Its Cationic Derivative Re-educate Tumor-Associated Macrophages for Synergistic Tumor Immunotherapy

(2020) Tingting Guo et al.   CARBOHYDRATE POLYMERS

Gemcitabine and checkpoint blockade exhibit synergistic anti-tumor effects in a model of murine lung carcinoma

(2020) Bin Du et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A targeted and redox/pH-responsive chitosan oligosaccharide derivatives based nanohybrids for overcoming multidrug resistance of breast cancer cells

(2020) Lejiao Jia et al.   CARBOHYDRATE POLYMERS

Effects of carboxymethyl chitosan oligosaccharide on regulating immunologic function and inhibiting tumor growth

(2020) Zhiwen Jiang et al.   CARBOHYDRATE POLYMERS

Distinct chemotherapy-associated anti-cancer immunity by myeloid cells inhibition in murine pancreatic cancer models

(2019) Yoshio Sakai et al.   CANCER SCIENCE

Easy and effective method to generate endotoxin-free chitosan particles for immunotoxicology and immunopharmacology studies

(2019) Filipa Lebre et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Cardiovascular toxicities associated with immune checkpoint inhibitors

(2019) Jiun-Ruey Hu et al.   CARDIOVASCULAR RESEARCH

Sequential Blockade of PD-1 and PD-L1 Causes Fulminant Cardiotoxicity—From Case Report to Mouse Model Validation

(2019) Shin-Yi Liu et al.   Cancers

Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma

(2019) Ram C. Shankaraiah et al.   ONCOGENE

Chitooligosaccharides display anti-tumor effects against human cervical cancer cells via the apoptotic and autophagic pathways

(2019) Mengyao Zhao et al.   CARBOHYDRATE POLYMERS

AMPK in skeletal muscle function and metabolism

(2018) Rasmus Kjøbsted et al.   FASEB JOURNAL

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Biochemical properties of a novel chitosanase from Bacillus amyloliquefaciens and its use in membrane reactor

(2018) Zhen Qin et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Metformin reverses established lung fibrosis in a bleomycin model

(2018) Sunad Rangarajan et al.   NATURE MEDICINE

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

(2018) Ryan M. Esquejo et al.   EBioMedicine

LPS promotes the expression of PD-L1 in gastric cancer cells through NF-κB activation

(2018) Hui Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

(2018) Lu Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Folate Receptor-Targeted and GSH-Responsive Carboxymethyl Chitosan Nanoparticles Containing Covalently Entrapped 6-Mercaptopurine for Enhanced Intracellular Drug Delivery in Leukemia

(2018) Xuan Wei et al.   Marine Drugs

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

(2018) Ioanna Keklikoglou et al.   NATURE CELL BIOLOGY

Perfluorocarbon Nanoparticles Mediated Platelet Blocking Disrupt Vascular Barriers to Improve the Efficacy of Oxygen-Sensitive Antitumor Drugs

(2018) Zaigang Zhou et al.   Small

Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy

(2018) Jinfang Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hydroxypropyltrimethyl ammonium chloride chitosan activates RAW 264.7 macrophages through the MAPK and JAK-STAT signaling pathways

(2018) Yue Yang et al.   CARBOHYDRATE POLYMERS

Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial

(2017) Arjun V Balar et al.   LANCET

First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study

(2017) Arjun V Balar et al.   LANCET ONCOLOGY

Oncolytic reovirus sensitizes multiple myeloma cells to anti-PD-L1 therapy

(2017) K R Kelly et al.   LEUKEMIA

Identification of essential genes for cancer immunotherapy

(2017) Shashank J. Patel et al.   NATURE

Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer

(2017) Scott J. Antonia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chitosan oligosaccharide: Biological activities and potential therapeutic applications

(2017) Chatchai Muanprasat et al.   PHARMACOLOGY & THERAPEUTICS

Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet

(2017) Angela Woods et al.   Cell Reports

Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-κB and mTOR signaling

(2016) Tharinee Mattaveewong et al.   CARBOHYDRATE POLYMERS

PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphoma

(2016) Xi-wen Bi et al.   Journal of Hematology & Oncology

Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial

(2016) Louis Fehrenbacher et al.   LANCET

Effect of Chitosan Properties on Immunoreactivity

(2016) Sruthi Ravindranathan et al.   Marine Drugs

Activation of AMPK by chitosan oligosaccharide in intestinal epithelial cells: Mechanism of action and potential applications in intestinal disorders

(2015) Chatchai Muanprasat et al.   BIOCHEMICAL PHARMACOLOGY

PD-L1 expression as a potential predictive biomarker

(2015) Alberto Fusi et al.   LANCET ONCOLOGY

Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats

(2015) Frank A Duca et al.   NATURE MEDICINE

Anti-tumor properties of orally administered glucosamine and N-acetyl-d-glucosamine oligomers in a mouse model

(2014) Sachie Masuda et al.   CARBOHYDRATE POLYMERS

Endotoxins affect diverse biological activity of chitosans in matters of hemocompatibility and cytocompatibility

(2014) Andrea Nolte et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Endotoxins affect bioactivity of chitosan derivatives in cultures of bone marrow-derived human mesenchymal stem cells

(2012) Ramona Lieder et al.   Acta Biomaterialia

AMP-Activated Protein Kinase Restricts IFN-  Signaling

(2012) G. P. Meares et al.   JOURNAL OF IMMUNOLOGY