Metformin Liposome-Mediated PD-L1 Downregulation for Amplifying the Photodynamic Immunotherapy Efficacy

Metformin-Induced Stromal Depletion to Enhance the Penetration of Gemcitabine-Loaded Magnetic Nanoparticles for Pancreatic Cancer Targeted Therapy

(2020) Haijie Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Titanium-Based Nanoscale Metal–Organic Framework for Type I Photodynamic Therapy

(2019) Guangxu Lan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light‐Triggered In Situ Gelation to Enable Robust Photodynamic‐Immunotherapy by Repeated Stimulations

(2019) Zhouqi Meng et al.   ADVANCED MATERIALS

Self‐Amplified Drug Delivery with Light‐Inducible Nanocargoes to Enhance Cancer Immunotherapy

(2019) Bing Feng et al.   ADVANCED MATERIALS

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

(2019) Rosina Pryor et al.   CELL

Defeating relapsed and refractory malignancies through a nano-enabled mitochondria-mediated respiratory inhibition and damage pathway

(2019) Zhengyang Yang et al.   BIOMATERIALS

Sheddable Prodrug Vesicles Combating Adaptive Immune Resistance for Improved Photodynamic Immunotherapy of Cancer

(2019) Ang Gao et al.   NANO LETTERS

Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy

(2018) Xingshu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

(2018) Bing Feng et al.   ADVANCED MATERIALS

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H2O2 and Catalase for Enhanced Radio-Immunotherapy of Cancer

(2018) Xuejiao Song et al.   NANO LETTERS

Targeting Programmed Cell Death -1 (PD-1) and Ligand (PD-L1): A new era in cancer active immunotherapy

(2018) Anastasia Constantinidou et al.   PHARMACOLOGY & THERAPEUTICS

Chemotherapeutic Treatments Increase PD-L1 Expression in Esophageal Squamous Cell Carcinoma through EGFR/ERK Activation

(2018) Hoi Yan Ng et al.   Translational Oncology

Two-stage oxygen delivery for enhanced radiotherapy by perfluorocarbon nanoparticles

(2018) Zaigang Zhou et al.   Theranostics

Enhancing Anti-PD-1/PD-L1 Immune Checkpoint Inhibitory Cancer Therapy by CD276-Targeted Photodynamic Ablation of Tumor Cells and Tumor Vasculature

(2018) Rui Bao et al.   MOLECULAR PHARMACEUTICS

Perfluorocarbon Nanoparticles Mediated Platelet Blocking Disrupt Vascular Barriers to Improve the Efficacy of Oxygen-Sensitive Antitumor Drugs

(2018) Zaigang Zhou et al.   Small

Tumor-pH-Responsive Dissociable Albumin-Tamoxifen Nanocomplexes Enabling Efficient Tumor Penetration and Hypoxia Relief for Enhanced Cancer Photodynamic Therapy

(2018) Zhijuan Yang et al.   Small

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

Phototheranostic nanoplatform based on a single cyanine dye for image-guided combinatorial phototherapy

(2017) Tony Duong et al.   Nanomedicine-Nanotechnology Biology and Medicine

Photodynamic-Immune Checkpoint Therapy Eradicates Local and Distant Tumors by CD8 + T Cells

(2017) Jan Willem Kleinovink et al.   Cancer Immunology Research

Neoadjuvant chemotherapy (NACT) increases immune infiltration and programmed death-ligand 1 (PD-L1) expression in epithelial ovarian cancer (EOC)

(2016) S J L Mesnage et al.   ANNALS OF ONCOLOGY

Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy

(2016) Ryan J.O. Dowling et al.   Cell Metabolism

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

(2016) Zijian Zhou et al.   CHEMICAL SOCIETY REVIEWS

Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy

(2016) Dangge Wang et al.   NANO LETTERS

Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

(2016) Hua Gong et al.   NANO LETTERS

Liposomes co-loaded with metformin and chlorin e6 modulate tumor hypoxia during enhanced photodynamic therapy

(2016) Xuejiao Song et al.   Nano Research

Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies

(2015) J. Naidoo et al.   ANNALS OF ONCOLOGY

IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer

(2015) K Abiko et al.   BRITISH JOURNAL OF CANCER

Current state of anti-PD-L1 and anti-PD-1 agents in cancer therapy

(2015) Abhisek Swaika et al.   MOLECULAR IMMUNOLOGY

Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway

(2015) Kim C. Ohaegbulam et al.   TRENDS IN MOLECULAR MEDICINE

Metformin in Patients With Type 2 Diabetes and Kidney Disease

(2014) Silvio E. Inzucchi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Photodynamic therapy of cancer: An update

(2011) Patrizia Agostinis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin

(2009) M V Tzvetkov et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Enhancement of anti-tumor immunity by photodynamic therapy

(2009) Sandra O. Gollnick et al.   IMMUNOLOGIC RESEARCH

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology