Metformin Enhances the Antitumor Activity of CD8+ T Lymphocytes via the AMPK–miR-107–Eomes–PD-1 Pathway

Metformin-repressed miR-381-YAP-snail axis activity disrupts NSCLC growth and metastasis

(2020) Dan Jin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IL-15-mediated reduction of mTORC1 activity preserves the stem cell memory phenotype of CAR-T cells and confers superior antitumor activity

(2019) Darya Alizadeh et al.   Cancer Immunology Research

NR4A transcription factors limit CAR T cell function in solid tumours

(2019) Joyce Chen et al.   NATURE

Role of Mitochondria in the Mechanism(s) of Action of Metformin

(2019) Guillaume Vial et al.   Frontiers in Endocrinology

Metformin mediated microRNA-7 upregulation inhibits growth, migration, and invasion of non-small cell lung cancer A549 cells

(2019) Jingying Dong et al.   ANTI-CANCER DRUGS

Regulation of Memory CD8+ T Cell Differentiation by MicroRNAs

(2018) Zhen Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MiR-184 expression is regulated by AMPK in pancreatic islets

(2018) Aida Martinez-Sanchez et al.   FASEB JOURNAL

Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness

(2018) Pedro Costa del Amo et al.   PLOS BIOLOGY

Metformin blocks myeloid-derived suppressor cell accumulation through AMPK-DACH1-CXCL1 axis

(2018) Guohui Qin et al.   OncoImmunology

miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism

(2018) Tengfei Zhang et al.   JOURNAL OF IMMUNOLOGY

Chimeric antigen receptor T cells: a novel therapy for solid tumors

(2017) Shengnan Yu et al.   Journal of Hematology & Oncology

Origin and differentiation of human memory CD8 T cells after vaccination

(2017) Rama S. Akondy et al.   NATURE

Downregulation of Rab27A contributes to metformin-induced suppression of breast cancer stem cells

(2017) Feixue Feng et al.   Oncology Letters

The Clinical Effect of Metformin on the Survival of Lung Cancer Patients with Diabetes: A Comprehensive Systematic Review and Meta-analysis of Retrospective Studies

(2017) Xun Cao et al.   Journal of Cancer

Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy

(2017) Ryan Urak et al.   Journal for ImmunoTherapy of Cancer

Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies

(2016) M. Sabatino et al.   BLOOD

Metformin use and its effect on survival in diabetic patients with advanced non-small cell lung cancer

(2016) Oscar Arrieta et al.   BMC CANCER

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

(2016) Lianfeng Wu et al.   CELL

Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses

(2016) Alison Taylor et al.   IMMUNITY

T-Cell Therapy Using Interleukin-21–Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persistence and Durable Tumor Regression

(2016) Aude G. Chapuis et al.   JOURNAL OF CLINICAL ONCOLOGY

Genetic and Epigenetic Regulation of PD-1 Expression

(2016) Alexander P. R. Bally et al.   JOURNAL OF IMMUNOLOGY

Role of memory T cell subsets for adoptive immunotherapy

(2016) Dirk H. Busch et al.   SEMINARS IN IMMUNOLOGY

AMPK-dependent and independent effects of AICAR and compound C on T-cell responses

(2016) Enyu Rao et al.   Oncotarget

Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux

(2016) Raya Ahmed et al.   Cell Reports

Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells

(2016) Godehard Scholz et al.   EBioMedicine

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+T cells

(2015) Pamela M. Odorizzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune-mediated antitumor effect by type 2 diabetes drug, metformin

(2015) Shingo Eikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell exhaustion in the tumor microenvironment

(2015) Y Jiang et al.   Cell Death & Disease

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Role of miR-107 and its signaling pathways in diseases

(2014) Zong-Pei Jiang et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Molecular regulation of effector and memory T cell differentiation

(2014) John T Chang et al.   NATURE IMMUNOLOGY

Moving T memory stem cells to the clinic

(2013) L. Gattinoni et al.   BLOOD

MicroRNA-17 92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections

(2013) A. A. Khan et al.   BLOOD

MicroRNA regulation of T-cell differentiation and function

(2013) Lukas T. Jeker et al.   IMMUNOLOGICAL REVIEWS

Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells

(2012) Enrico Lugli et al.   Nature Protocols

Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation

(2012) T. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The specificities of small molecule inhibitors of the TGFß and BMP pathways

(2011) Janis Vogt et al.   CELLULAR SIGNALLING

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

HER2-Specific T Cells Target Primary Glioblastoma Stem Cells and Induce Regression of Autologous Experimental Tumors

(2010) N. Ahmed et al.   CLINICAL CANCER RESEARCH

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

(2010) A. Banerjee et al.   JOURNAL OF IMMUNOLOGY

Distinct regulation of effector and memory T-cell differentiation

(2008) Axel Kallies   IMMUNOLOGY AND CELL BIOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL