Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication

Immunometabolism is a key factor for the persistent spontaneous elite control of HIV-1 infection

(2019) Laura Tarancon-Diez et al.   EBioMedicine

TMT labeling for the masses: A robust and cost-efficient, in-solution labeling approach

(2019) Jana Zecha et al.   MOLECULAR & CELLULAR PROTEOMICS

Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol

(2019) Jean-Pierre Routy et al.   BMJ Open

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection

(2018) José Carlos Valle-Casuso et al.   Cell Metabolism

The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity

(2018) Toru Uchimura et al.   IMMUNITY

The impact of diabetes on CD4 recovery in persons with HIV in an urban clinic in the United States

(2017) Julie A Zuniga et al.   INTERNATIONAL JOURNAL OF STD & AIDS

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

(2017) Geurt Stokman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys

(2016) Dan H. Barouch et al.   CELL

NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses

(2016) Haitao Guo et al.   Cell Host & Microbe

Glycosylphosphatidylinositol-Anchored Anti-HIV scFv Efficiently Protects CD4 T Cells from HIV-1 Infection and Deletion in hu-PBL Mice

(2016) Chaobaihui Ye et al.   JOURNAL OF VIROLOGY

EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1–TUFM protein complex

(2016) Y Lei et al.   ONCOGENE

The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals

(2016) A. Alicia Koblansky et al.   Cell Reports

Current topics in HIV-1 pathogenesis: The emergence of deregulated immuno-metabolism in HIV-infected subjects

(2015) Xavier Dagenais-Lussier et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A Mitochondria-Specific Isoform of FASTK Is Present In Mitochondrial RNA Granules and Regulates Gene Expression and Function

(2015) Alexis A. Jourdain et al.   Cell Reports

Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis

(2015) Hana Antonicka et al.   Cell Reports

Cohort study of diabetes in HIV-infected adult patients: Evaluating the effect of diabetes mellitus on immune reconstitution

(2014) D. Moyo et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

HIV-1 Infection Induces Interleukin-1β Production via TLR8 Protein-dependent and NLRP3 Inflammasome Mechanisms in Human Monocytes

(2014) Haitao Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

HIV-1 pathogenicity and virion production are dependent on the metabolic phenotype of activated CD4+ T cells

(2014) Andrea Hegedus et al.   Retrovirology

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection

(2013) Clovis S. Palmer et al.   AIDS

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Incomplete Immune Recovery in HIV Infection: Mechanisms, Relevance for Clinical Care, and Possible Solutions

(2012) Julie C. Gaardbo et al.   Clinical & Developmental Immunology

The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy

(2012) Yu Lei et al.   IMMUNITY

Body Composition and Metabolic Changes in HIV-Infected Patients

(2012) Takara L. Stanley et al.   JOURNAL OF INFECTIOUS DISEASES

Metabolic pathways in T cell fate and function

(2012) Valerie A. Gerriets et al.   TRENDS IN IMMUNOLOGY

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

(2011) Shitao Li et al.   IMMUNITY

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Resveratrol induces mitochondrial biogenesis in endothelial cells

(2009) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dynamic Host Energetics and Cytoskeletal Proteomes in Human Immunodeficiency Virus Type 1-Infected Human Primary CD4 Cells: Analysis by Multiplexed Label-Free Mass Spectrometry

(2009) E. Y. Chan et al.   JOURNAL OF VIROLOGY

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

(2008) Renate König et al.   CELL

Proteomic Studies Reveal Coordinated Changes in T-Cell Expression Patterns upon Infection with Human Immunodeficiency Virus Type 1

(2008) J. H. Ringrose et al.   JOURNAL OF VIROLOGY

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function

(2008) Sara Mostafavi et al.   GENOME BIOLOGY