Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma

Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells

(2014) Ummuhan Demir et al.   BMC CANCER

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Genetic Polymorphisms in DNA Repair Genes XRCC4 and XRCC5 and Aflatoxin B1–related Hepatocellular Carcinoma

(2013) Xi-Dai Long et al.   EPIDEMIOLOGY

Polymorphisms in the coding region of X-ray repair complementing group 4 and aflatoxin B1-related hepatocellular carcinoma

(2013) Xi-Dai Long et al.   HEPATOLOGY

Metformin Use and All-Cause and Prostate Cancer–Specific Mortality Among Men With Diabetes

(2013) David Margel et al.   JOURNAL OF CLINICAL ONCOLOGY

15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARγ-mediated activation of p21WAF1/Cip1

(2013) D Lu et al.   ONCOGENE

Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies

(2012) Hsiao-Ping Chen et al.   GUT

Risk factors for intrahepatic cholangiocarcinoma: Association between metformin use and reduced cancer risk

(2012) Roongruedee Chaiteerakij et al.   HEPATOLOGY

In vitro and in vivo antitumoral action of metformin on hepatocellular carcinoma

(2012) Zhan Qu et al.   HEPATOLOGY RESEARCH

Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth

(2011) G. Z. Rocha et al.   CLINICAL CANCER RESEARCH

Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3

(2011) Runqiu Jiang et al.   HEPATOLOGY

In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression

(2011) Ogyi Park et al.   HEPATOLOGY

Recent advances in IL-22 biology

(2011) L. A. Zenewicz et al.   INTERNATIONAL IMMUNOLOGY

Impact of Metformin on the Prognosis of Cirrhosis Induced by Viral Hepatitis C in Diabetic Patients

(2011) Gisèle Nkontchou et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

IL-22 Production Is Regulated by IL-23 During Listeria monocytogenes Infection but Is Not Required for Bacterial Clearance or Tissue Protection

(2011) Amy C. Graham et al.   PLoS One

A novel role for IL-22R1 as a driver of inflammation

(2010) R. Savan et al.   BLOOD

Metformin: A Therapeutic Opportunity in Breast Cancer

(2010) A. M. Gonzalez-Angulo et al.   CLINICAL CANCER RESEARCH

Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer

(2010) M. Bodmer et al.   DIABETES CARE

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase

(2010) Carolyn Algire et al.   ENDOCRINE-RELATED CANCER

Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease

(2010) Valter Donadon et al.   LIVER INTERNATIONAL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antidiabetic Therapies Affect Risk of Pancreatic Cancer

(2009) Donghui Li et al.   GASTROENTEROLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

RAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinoma

(2008) Hung Huynh et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE