Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease

(2022) Larissa Traxler et al.   Cell Metabolism

Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration

(2022) Gwyneth M. Welch et al.   Science Advances

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

(2021) Mikolaj Ogrodnik et al.   AGING CELL

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells—Implications for Cancer and Neurodegeneration

(2021) Gregory J. Gillispie et al.   Life-Basel

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

(2021) Jerome Mertens et al.   Cell Stem Cell

Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons

(2021) Dylan A. Reid et al.   SCIENCE

Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease

(2021) Samuel Morabito et al.   NATURE GENETICS

Targeting senescent cells improves functional recovery after spinal cord injury

(2021) Diogo Paramos-de-Carvalho et al.   Cell Reports

Astrocyte senescence promotes glutamate toxicity in cortical neurons

(2020) Chandani Limbad et al.   PLoS One

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Cancer and Alzheimer’s disease inverse relationship: an age-associated diverging derailment of shared pathways

(2020) Cristina Lanni et al.   MOLECULAR PSYCHIATRY

Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation

(2020) Narmen Azazmeh et al.   Nature Communications

Astrocyte Senescence and Alzheimer’s Disease: A Review

(2020) Xiaojuan Han et al.   Frontiers in Aging Neuroscience

Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds

(2020) Holly N. Wilkinson et al.   Frontiers in Cell and Developmental Biology

A guide to assessing cellular senescence in vitro and in vivo

(2020) Estela González‐Gualda et al.   FEBS Journal

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

(2019) Simon T. Schafer et al.   NATURE NEUROSCIENCE

The single-cell transcriptional landscape of mammalian organogenesis

(2019) Junyue Cao et al.   NATURE

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

(2019) Joseph Herdy et al.   eLife

Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy

(2019) Daniel Moreno-Blas et al.   Aging-US

Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons

(2019) Markus Riessland et al.   Cell Stem Cell

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

(2019) Hei-Man Chow et al.   NATURE NEUROSCIENCE

Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer’s disease

(2019) Christopher D. Whelan et al.   Acta Neuropathologica Communications

Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation

(2018) Hanlin Zeng et al.   CANCER CELL

Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

(2018) Matheus B. Victor et al.   NATURE NEUROSCIENCE

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

(2018) Przemyslaw Sapieha et al.   TRENDS IN CELL BIOLOGY

Author Correction: Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury

(2018) Lisa J. Hill et al.   Scientific Reports

Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile

(2018) Yongsung Kim et al.   Cell Reports

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases

(2018) Jerome Mertens et al.   Annual Review of Genetics

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Direct Conversion of Mouse Fibroblasts into Neural Stem Cells by Chemical Cocktail Requires Stepwise Activation of Growth Factors and Nup210

(2018) Yuewen Tang et al.   Cell Reports

The bystander effect contributes to the accumulation of senescent cells in vivo

(2018) Paulo F. L. da Silva et al.   AGING CELL

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT

(2017) K Zhang et al.   ONCOGENE

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

(2017) Kévin Contrepois et al.   Nature Communications

Neuropathological and transcriptomic characteristics of the aged brain

(2017) Jeremy A Miller et al.   eLife

The immunoglobulin-like superfamily member IGSF3 is a developmentally regulated protein that controls neuronal morphogenesis

(2016) Alessia Usardi et al.   Developmental Neurobiology

Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics

(2016) Adam E. Handel et al.   HUMAN MOLECULAR GENETICS

Identification of Senescent Cells in the Bone Microenvironment

(2016) Joshua N Farr et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

(2016) Christine J Huh et al.   eLife

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Generation of functional human serotonergic neurons from fibroblasts

(2015) K C Vadodaria et al.   MOLECULAR PSYCHIATRY

Pathway-specific reorganization of projection neurons in somatosensory cortex during learning

(2015) Jerry L Chen et al.   NATURE NEUROSCIENCE

Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites

(2015) Sonja Hänzelmann et al.   Clinical Epigenetics

Inverse correlation between Alzheimer’s disease and cancer: implication for a strong impact of regenerative propensity on neurodegeneration?

(2014) Jian-Ming Li et al.   BMC Neurology

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Small molecules enable highly efficient neuronal conversion of human fibroblasts

(2012) Julia Ladewig et al.   NATURE METHODS

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

Cellular senescence and tumor suppressor gene p16

(2011) Hani Rayess et al.   INTERNATIONAL JOURNAL OF CANCER

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The involvement of cell cycle events in the pathogenesis of Alzheimer's disease

(2010) Karl Herrup   Alzheimers Research & Therapy

Statistical Analysis of 3D Images Detects Regular Spatial Distributions of Centromeres and Chromocenters in Animal and Plant Nuclei

(2010) Philippe Andrey et al.   PLoS Computational Biology

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

A quantitative real-time PCR method for absolute telomere length

(2008) Nathan J. O'Callaghan et al.   BIOTECHNIQUES

Astroglia in dementia and Alzheimer's disease

(2008) J J Rodríguez et al.   CELL DEATH AND DIFFERENTIATION