Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds
Authors
Keywords
-
Journal
Frontiers in Cell and Developmental Biology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-08-11
DOI
10.3389/fcell.2020.00773
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Wound senescence: A functional link between diabetes and ageing?
- (2020) Holly N. Wilkinson et al. EXPERIMENTAL DERMATOLOGY
- Senescence in Post-Mitotic Cells: A Driver of Aging?
- (2020) Thomas von Zglinicki et al. ANTIOXIDANTS & REDOX SIGNALING
- Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts
- (2020) Patrick M. Perrigue et al. Cancers
- An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
- (2019) Ilias Angelidis et al. Nature Communications
- Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2
- (2019) Holly N. Wilkinson et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells
- (2019) Aixia Sui et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation
- (2019) Steve Horvath et al. Aging-US
- Strain- and Species-Level Variation in the Microbiome of Diabetic Wounds Is Associated with Clinical Outcomes and Therapeutic Efficacy
- (2019) Lindsay R. Kalan et al. Cell Host & Microbe
- The senescence-associated secretory phenotype and its regulation
- (2019) Stéphane Lopes-Paciencia et al. CYTOKINE
- Type 2 diabetes is associated with the accumulation of senescent T cells
- (2019) E. Y. M. Lau et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Reduced iron in diabetic wounds: An oxidative stress-dependent role for STEAP3 in extracellular matrix deposition and remodelling
- (2019) Holly N. Wilkinson et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
- (2019) Branca I. Pereira et al. Nature Communications
- Tissue Iron Promotes Wound Repair via M2 Macrophage Polarization and the Chemokine (C-C Motif) Ligands 17 and 22
- (2019) Holly N. Wilkinson et al. AMERICAN JOURNAL OF PATHOLOGY
- Cellular senescence in development, regeneration and disease
- (2019) Muriel Rhinn et al. DEVELOPMENT
- Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival
- (2019) Crystal A. Tonnessen-Murray et al. JOURNAL OF CELL BIOLOGY
- Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
- (2019) LaTonya J. Hickson et al. EBioMedicine
- Cell senescence contributes to tissue regeneration in zebrafish
- (2019) Sabela Da Silva‐Álvarez et al. AGING CELL
- Targeting senescent cells: approaches, opportunities, challenges
- (2019) Cayetano von Kobbe Aging-US
- Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging
- (2019) Jacob C. Kimmel et al. GENOME RESEARCH
- The development of cell senescence
- (2019) Sabela Da Silva-Álvarez et al. EXPERIMENTAL GERONTOLOGY
- Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome
- (2018) Paul Hiebert et al. DEVELOPMENTAL CELL
- Strategies targeting cellular senescence
- (2018) Yossi Ovadya et al. JOURNAL OF CLINICAL INVESTIGATION
- Senolytics improve physical function and increase lifespan in old age
- (2018) Ming Xu et al. NATURE MEDICINE
- CAR T cell immunotherapy for human cancer
- (2018) Carl H. June et al. SCIENCE
- Hallmarks of Cellular Senescence
- (2018) Alejandra Hernandez-Segura et al. TRENDS IN CELL BIOLOGY
- Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways
- (2018) Takahiro Ito et al. Cell Reports
- The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis
- (2018) Cristina Albanesi et al. Frontiers in Immunology
- Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages
- (2018) Francesco Prattichizzo et al. Redox Biology
- Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice
- (2018) Adam D. Hudgins et al. Frontiers in Genetics
- Cellular Senescence: The Sought or the Unwanted?
- (2018) Yu Sun et al. TRENDS IN MOLECULAR MEDICINE
- Fisetin is a senotherapeutic that extends health and lifespan
- (2018) Matthew J. Yousefzadeh et al. EBioMedicine
- Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing
- (2018) Simon Joost et al. Cell Reports
- The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
- (2017) Birgit Ritschka et al. GENES & DEVELOPMENT
- Pathogenesis of wound healing disorders in the elderly
- (2017) Evgenia Makrantonaki et al. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
- Senescence and aging: Causes, consequences, and therapeutic avenues
- (2017) Domhnall McHugh et al. JOURNAL OF CELL BIOLOGY
- The role of estrogen in cutaneous ageing and repair
- (2017) Holly N. Wilkinson et al. MATURITAS
- Metformin accelerates wound healing in type 2 diabetic db/db mice
- (2017) Xue Han et al. Molecular Medicine Reports
- Loss of lamin B1 is a biomarker to quantify cellular senescence in photoaged skin
- (2017) Audrey Shimei Wang et al. Scientific Reports
- Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli
- (2016) L. A. Maciel-Barón et al. AGE
- Biomarkers to identify and isolate senescent cells
- (2016) Mantas Matjusaitis et al. AGEING RESEARCH REVIEWS
- Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
- (2016) Carolyn M. Roos et al. AGING CELL
- NKG2D ligands mediate immunosurveillance of senescent cells
- (2016) Adi Sagiv et al. Aging-US
- FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells
- (2016) Artem Smirnov et al. Aging-US
- Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
- (2016) Brandon M. Hall et al. Aging-US
- Wound repair: a showcase for cell plasticity and migration
- (2016) Tanya J Shaw et al. CURRENT OPINION IN CELL BIOLOGY
- Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
- (2016) Marissa J. Schafer et al. DIABETES
- Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis
- (2016) Kathleen Meyer et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
- p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
- (2016) Aharon Helman et al. NATURE MEDICINE
- Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
- (2016) Andrew W. Roberts et al. NEW ENGLAND JOURNAL OF MEDICINE
- “Inflammaging” as a Druggable Target: A Senescence-Associated Secretory Phenotype—Centered View of Type 2 Diabetes
- (2016) Francesco Prattichizzo et al. Oxidative Medicine and Cellular Longevity
- Wound management for the 21st century: combining effectiveness and efficiency
- (2016) Christina Lindholm et al. International Wound Journal
- Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
- (2016) Reut Yosef et al. Nature Communications
- BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance
- (2016) N. Tasdemir et al. Cancer Discovery
- Dasatinib for the treatment of chronic myeloid leukemia: patient selection and special considerations
- (2016) Dilek Keskin et al. Drug Design Development and Therapy
- Molecular Targets Underlying the Anticancer Effects of Quercetin: An Update
- (2016) Fazlullah Khan et al. Nutrients
- Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle
- (2016) Ling Yang et al. Cell Reports
- CCN2 induces cellular senescence in fibroblasts
- (2016) Joon-II Jun et al. Journal of Cell Communication and Signaling
- Adult-onset, short-term dietary restriction reduces cell senescence in mice
- (2016) Chunfang Wang et al. Aging-US
- Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
- (2016) Michael C. Velarde et al. Aging-US
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients
- (2015) Hagai Yanai et al. Aging-US
- The CXCR1/2 Pathway: Involvement in Diabetes Pathophysiology and Potential Target for T1D Interventions
- (2015) Antonio Citro et al. Current Diabetes Reports
- Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing
- (2015) Rajarajan A. Thandavarayan et al. EXPERIMENTAL DERMATOLOGY
- Advanced glycation end-products accelerate the cardiac aging process through the receptor for advanced glycation end-products/transforming growth factor-β-Smad signaling pathway in cardiac fibroblasts
- (2015) Min Fang et al. Geriatrics & Gerontology International
- Characterization of Skin Aging–Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin
- (2015) Daniel M. Waldera Lupa et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
- (2015) Ming Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice
- (2015) Seidai Sato et al. Nature Communications
- Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development
- (2015) Yaosen Wu et al. Scientific Reports
- Health economic burden that wounds impose on the National Health Service in the UK
- (2015) Julian F Guest et al. BMJ Open
- Recurrent turnover of senescent cells during regeneration of a complex structure
- (2015) Maximina H Yun et al. eLife
- Metalloproteinases and Wound Healing
- (2015) Matthew P. Caley et al. Advances in Wound Care
- Challenges in the Treatment of Chronic Wounds
- (2015) Robert G. Frykberg et al. Advances in Wound Care
- Intermittent High Glucose Implements Stress-Induced Senescence in Human Vascular Endothelial Cells: Role of Superoxide Production by NADPH Oxidase
- (2015) Morihiko Maeda et al. PLoS One
- Retarding the senescence of human vascular endothelial cells induced by hydrogen peroxide: effects of 17beta-estradiol (E2) mediated mitochondria protection
- (2014) Yunjun Ruan et al. BIOGERONTOLOGY
- A new inflammatory role for p53 in human macrophages
- (2014) Julie M Lowe et al. CELL CYCLE
- Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal
- (2014) Deqiang Sun et al. Cell Stem Cell
- Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
- (2014) Yi Zhu et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Senescence and apoptosis: dueling or complementary cell fates?
- (2014) B. G. Childs et al. EMBO REPORTS
- The hallmarks of fibroblast ageing
- (2014) Julia Tigges et al. MECHANISMS OF AGEING AND DEVELOPMENT
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
- Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
- (2014) Ricki J. Colman et al. Nature Communications
- Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation
- (2013) Olga Moiseeva et al. AGING CELL
- Non-Cell-Autonomous Tumor Suppression by p53
- (2013) Amaia Lujambio et al. CELL
- Programmed Cell Senescence during Mammalian Embryonic Development
- (2013) Daniel Muñoz-Espín et al. CELL
- Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
- (2013) Mekayla Storer et al. CELL
- Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
- (2013) P. P. Shah et al. GENES & DEVELOPMENT
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms
- (2013) T Velnar et al. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- A complex secretory program orchestrated by the inflammasome controls paracrine senescence
- (2013) Juan Carlos Acosta et al. NATURE CELL BIOLOGY
- DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
- (2013) T. A. Watkins et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging
- (2013) Ling Liu et al. Cell Reports
- p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice
- (2013) Darren J. Baker et al. Cell Reports
- DNA methylation age of human tissues and cell types
- (2013) Steve Horvath GENOME BIOLOGY
- The number of p16INK4a positive cells in human skin reflects biological age
- (2012) Mariëtte E.C. Waaijer et al. AGING CELL
- Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
- (2012) Diana Jurk et al. AGING CELL
- Aging, Cellular Senescence, and Cancer
- (2012) Judith Campisi Annual Review of Physiology
- Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression
- (2012) E. Pazolli et al. CANCER RESEARCH
- Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells
- (2012) Moussa Benhamed et al. NATURE CELL BIOLOGY
- Plasminogen activator inhibitor 1 - insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence
- (2012) David J. Elzi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Advanced Glycation End Products Are Direct Modulators of -Cell Function
- (2011) M. T. Coughlan et al. DIABETES
- p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
- (2011) Adam Freund et al. EMBO JOURNAL
- Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity
- (2011) Y. Chien et al. GENES & DEVELOPMENT
- Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype
- (2011) Jean-Philippe Coppé et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Four faces of cellular senescence
- (2011) Francis Rodier et al. JOURNAL OF CELL BIOLOGY
- An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice
- (2011) Anca Sindrilaru et al. JOURNAL OF CLINICAL INVESTIGATION
- AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan
- (2011) Antero Salminen et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: Results from the calerie trial of human caloric restriction
- (2011) Mohsen Meydani et al. Journal of Nutrition Health & Aging
- The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations
- (2011) David J Bonda et al. LANCET NEUROLOGY
- Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
- (2011) Tae-Won Kang et al. NATURE
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Modulation of Macrophage Efferocytosis in Inflammation
- (2011) Darlynn Korns et al. Frontiers in Immunology
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- The essence of senescence
- (2010) T. Kuilman et al. GENES & DEVELOPMENT
- Impact of long-term caloric restriction on cardiac senescence: Caloric restriction ameliorates cardiac diastolic dysfunction associated with aging
- (2010) Ken Shinmura et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Feedback between p21 and reactive oxygen production is necessary for cell senescence
- (2010) João F Passos et al. Molecular Systems Biology
- The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
- (2010) Joon-Il Jun et al. NATURE CELL BIOLOGY
- The p16INK4A tumor suppressor regulates cellular oxidative stress
- (2010) N C Jenkins et al. ONCOGENE
- Paradoxical suppression of cellular senescence by p53
- (2010) Z. N. Demidenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inflammatory networks during cellular senescence: causes and consequences
- (2010) Adam Freund et al. TRENDS IN MOLECULAR MEDICINE
- Pseudomonas pyocyanin inhibits wound repair by inducing premature cellular senescence: Role for p38 mitogen-activated protein kinase
- (2009) Michael Muller et al. BURNS
- Blinded by the Light: The Growing Complexity of p53
- (2009) Karen H. Vousden et al. CELL
- The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
- (2009) K. Agger et al. GENES & DEVELOPMENT
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
- (2009) Francis Rodier et al. NATURE CELL BIOLOGY
- A crucial role for adipose tissue p53 in the regulation of insulin resistance
- (2009) Tohru Minamino et al. NATURE MEDICINE
- Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo
- (2009) Florence Debacq-Chainiaux et al. Nature Protocols
- Cell surface-bound IL-1 is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
- (2009) A. V. Orjalo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin
- (2009) Philippe A. Grange et al. PLoS Pathogens
- Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
- (2008) Thomas Kuilman et al. CELL
- Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
- (2008) Juan C. Acosta et al. CELL
- Senescence of Activated Stellate Cells Limits Liver Fibrosis
- (2008) Valery Krizhanovsky et al. CELL
- Human skin stem cells and the ageing process
- (2008) Christos C. Zouboulis et al. EXPERIMENTAL GERONTOLOGY
- Fibroblast Dysfunction Is a Key Factor in the Non-Healing of Chronic Venous Leg Ulcers
- (2008) Ivan B. Wall et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
- (2008) Darren J. Baker et al. NATURE CELL BIOLOGY
- Cancer as an overhealing wound: an old hypothesis revisited
- (2008) Matthias Schäfer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Autophagy and aging: keeping that old broom working
- (2008) Ana Maria Cuervo TRENDS IN GENETICS
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started