Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Injured adult neurons regress to an embryonic transcriptional growth state

(2020) Gunnar H. D. Poplawski et al.   NATURE

Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury

(2020) William Renthal et al.   NEURON

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

(2019) Simon T. Schafer et al.   NATURE NEUROSCIENCE

Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons

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REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

(2019) Katharina Meyer et al.   Cell Reports

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

(2019) Rik van der Kant et al.   Cell Stem Cell

Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation

(2019) Steve Horvath et al.   Aging-US

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

(2019) Joseph Herdy et al.   eLife

Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons

(2019) Markus Riessland et al.   Cell Stem Cell

Next‐generation disease modeling with direct conversion: a new path to old neurons

(2019) Larissa Traxler et al.   FEBS LETTERS

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

(2019) Alexandra Grubman et al.   NATURE NEUROSCIENCE

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

(2019) Hei-Man Chow et al.   NATURE NEUROSCIENCE

Epigenetic regulation of brain region-specific microglia clearance activity

(2018) Pinar Ayata et al.   NATURE NEUROSCIENCE

Open chromatin dynamics reveals stage-specific transcriptional networks in hiPSC-based neurodevelopmental model

(2018) Siwei Zhang et al.   Stem Cell Research

Progress in Understanding and Treating SCN2A -Mediated Disorders

(2018) Stephan J. Sanders et al.   TRENDS IN NEUROSCIENCES

Whole transcriptome profiling of Late-Onset Alzheimer’s Disease patients provides insights into the molecular changes involved in the disease

(2018) Anita Annese et al.   Scientific Reports

Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile

(2018) Yongsung Kim et al.   Cell Reports

Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

(2018) Zaijun Ma et al.   eLife

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

(2018) Steve Horvath et al.   Aging-US

Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases

(2018) Jerome Mertens et al.   Annual Review of Genetics

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

Alzheimer's disease: The right drug, the right time

(2018) Todd E. Golde et al.   SCIENCE

Cardiac regeneration strategies: Staying young at heart

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Aging: Somatic Mutations, Epigenetic Drift and Gene Dosage Imbalance

(2017) Reiner A. Veitia et al.   TRENDS IN CELL BIOLOGY

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

(2017) Kévin Contrepois et al.   Nature Communications

Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons

(2017) Yu Tang et al.   Frontiers in Molecular Neuroscience

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs

(2016) Eunju Kang et al.   Cell Stem Cell

Altered Proteins in the Aging Brain

(2016) Adila Elobeid et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

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(2016) Philip Scheltens et al.   LANCET

Influence of donor age on induced pluripotent stem cells

(2016) Valentina Lo Sardo et al.   NATURE BIOTECHNOLOGY

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration

(2016) Melanie von Schimmelmann et al.   NATURE NEUROSCIENCE

Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style

(2016) Allyson J. Merrell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic drift, epigenetic clocks and cancer risk

(2016) Shijie C Zheng et al.   Epigenomics

Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities

(2016) Francesca Pistollato et al.   Oncotarget

Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

(2016) Chongyuan Luo et al.   Cell Reports

Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

(2016) Christine J Huh et al.   eLife

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

(2016) Mariet Allen et al.   Scientific Data

The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease

(2016) Antonio Currais et al.   Aging-US

2015 Alzheimer's disease facts and figures

(2015)   Alzheimers & Dementia

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Elucidating Molecular Phenotypes Caused by the SORL1 Alzheimer’s Disease Genetic Risk Factor Using Human Induced Pluripotent Stem Cells

(2015) Jessica E. Young et al.   Cell Stem Cell

REST Regulates Non-Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II

(2015) H. J. Kim et al.   JOURNAL OF NEUROSCIENCE

Generation of functional human serotonergic neurons from fibroblasts

(2015) K C Vadodaria et al.   MOLECULAR PSYCHIATRY

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

(2015) Jerome Mertens et al.   NATURE

Understanding the cause of sporadic Alzheimer’s disease

(2014) Henrik Zetterberg et al.   Expert Review of Neurotherapeutics

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells

(2014) Jason L. Stein et al.   NEURON

Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts

(2014) Matheus B. Victor et al.   NEURON

Modeling motor neuron disease: the matter of time

(2014) Mandana Arbab et al.   TRENDS IN NEUROSCIENCES

Embryonic Stem Cell–Based Modeling of Tau Pathology in Human Neurons

(2013) Jerome Mertens et al.   AMERICAN JOURNAL OF PATHOLOGY

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

(2013) A. E. Teschendorff et al.   HUMAN MOLECULAR GENETICS

Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage

(2013) Mirang Kim et al.   HUMAN MOLECULAR GENETICS

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism

(2013) James D. Mills et al.   NEUROSCIENCE LETTERS

Mature neurons: equipped for survival

(2013) A J Kole et al.   Cell Death & Disease

Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons

(2013) Meng-Lu Liu et al.   Nature Communications

The Presenilin-1 ΔE9 Mutation Results in Reduced γ-Secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells

(2013) Grace Woodruff et al.   Cell Reports

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

APP Processing in Human Pluripotent Stem Cell-Derived Neurons Is Resistant to NSAID-Based γ-Secretase Modulation

(2013) Jerome Mertens et al.   Stem Cell Reports

Presenilin-1 L166P Mutant Human Pluripotent Stem Cell–Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-β Generation

(2012) Philipp Koch et al.   AMERICAN JOURNAL OF PATHOLOGY

Cell Cycle Activation and Aneuploid Neurons in Alzheimer's Disease

(2012) Thomas Arendt   MOLECULAR NEUROBIOLOGY

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Small molecules enable highly efficient neuronal conversion of human fibroblasts

(2012) Julia Ladewig et al.   NATURE METHODS

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Defining the nature of human pluripotent stem cell progeny

(2011) Michaela Patterson et al.   CELL RESEARCH

Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease

(2011) Eric M. Blalock et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rank–rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures

(2010) Seema B. Plaisier et al.   NUCLEIC ACIDS RESEARCH

Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease

(2008) Sun-Chong Wang et al.   PLoS One