Biomarker‐Responsive Nanosystems for Chronic Disease Theranostics

Depleting Tumor Infiltrating B Cells to Boost Antitumor Immunity with Tumor Immune-Microenvironment Reshaped Hybrid Nanocage

(2022) Li Guan et al.   ACS Nano

pH-Responsive On-Demand Alkaloids Release from Core–Shell ZnO@ZIF-8 Nanosphere for Synergistic Control of Bacterial Wilt Disease

(2022) Wenlong Liang et al.   ACS Nano

Tumor-Acidity and Bioorthogonal Chemistry-Mediated On-Site Size Transformation Clustered Nanosystem to Overcome Hypoxic Resistance and Enhance Chemoimmunotherapy

(2022) Kewei Wang et al.   ACS Nano

A Smart Theranostic Prodrug System Activated by Reactive Oxygen Species for Regional Chemotherapy of Metastatic Cancer

(2022) Lingyan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NIR-II Functional Materials for Photoacoustic Theranostics

(2022) Zhifang Li et al.   BIOCONJUGATE CHEMISTRY

All‐in‐One Theranostic Platform Based on Hollow Microcapsules for Intragastric‐Targeting Antiulcer Drug Delivery, CT Imaging, and Synergistically Healing Gastric Ulcer

(2022) Qi Wang et al.   Small

Boosting Cholesterol Efflux from Foam Cells by Sequential Administration of rHDL to Deliver MicroRNA and to Remove Cholesterol in a Triple‐Cell 2D Atherosclerosis Model

(2022) Shifa Jebari‐Benslaiman et al.   Small

Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis

(2022) Luoyuan Li et al.   Advanced Science

Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis

(2022) Yekkuni L. Balachandran et al.   ACS Nano

Self-Enhanced Acoustic Impedance Difference Strategy for Detecting the Acidic Tumor Microenvironment

(2022) Xianfu Meng et al.   ACS Nano

Targeting the Microenvironment of Vulnerable Atherosclerotic Plaques: An Emerging Diagnosis and Therapy Strategy for Atherosclerosis

(2022) Shuai Zhang et al.   ADVANCED MATERIALS

A Hybrid Supramolecular Polymeric Nanomedicine for Cascade‐Amplified Synergetic Cancer Therapy

(2022) Kai Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Versatile nanomaterials for Alzheimer's disease: Pathogenesis inspired disease-modifying therapy

(2022) Yilong Xi et al.   JOURNAL OF CONTROLLED RELEASE

Stimuli-Responsive Macrocyclization Scaffold Allows In Situ Self-Assembly of Radioactive Tracers for Positron Emission Tomography Imaging of Enzyme Activity

(2022) Jianguo Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acid-Resistant and Physiological pH-Responsive DNA Hydrogel Composed of A-Motif and i-Motif toward Oral Insulin Delivery

(2022) Yuwei Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Supramolecular Core–Shell Nanoassemblies with Tumor Microenvironment‐Triggered Size and Structure Switch for Improved Photothermal Therapy

(2022) Ziyao Wang et al.   Small

Oxygen Self‐Supply Engineering‐Ferritin for the Relief of Hypoxia in Tumors and the Enhancement of Photodynamic Therapy Efficacy

(2022) Yang Zhu et al.   Small

Copper‐based nanomaterials for cancer theranostics

(2022) Xiaoyan Zhong et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases

(2022) Yanjing Ji et al.   Frontiers in Physiology

Medical Gas Therapy for Tissue, Organ, and CNS Protection: A Systematic Review of Effects, Mechanisms, and Challenges

(2022) Ross D. Zafonte et al.   Advanced Science

Acid‐Responsive Dual‐Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder

(2022) Xueqin He et al.   Advanced Science

Endogenous H2S-Activated Orthogonal Second Near-Infrared Emissive Nanoprobe for In Situ Ratiometric Fluorescence Imaging of Metformin-Induced Liver Injury

(2021) Zhiming Deng et al.   ACS Nano

Endogenous Enzyme-responsive Nanoplatforms for Anti-tumor Therapy

(2021) Xue-Fang Lou et al.   CURRENT DRUG TARGETS

Hypoxia-Triggered Self-Assembly of Ultrasmall Iron Oxide Nanoparticles to Amplify the Imaging Signal of a Tumor

(2021) Huige Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A relaxin-based nanotherapy for liver fibrosis

(2021) Jonathan A. Fallowfield et al.   Nature Nanotechnology

Mitochondrial Damage‐Induced Innate Immune Activation in Vascular Smooth Muscle Cells Promotes Chronic Kidney Disease‐Associated Plaque Vulnerability

(2021) Xianjin Bi et al.   Advanced Science

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

(2021) Alexander B. Cook et al.   ACS Nano

Quantitative Assessment of Copper(II) in Wilson’s Disease Based on Photoacoustic Imaging and Ratiometric Surface-Enhanced Raman Scattering

(2021) Hongjuan Feng et al.   ACS Nano

Dye‐Sensitized Downconversion Nanoprobes with Emission Beyond 1500 nm for Ratiometric Visualization of Cancer Redox State

(2021) Chenlu Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Hydrogen‐Powered Microswimmers for Precise and Active Hydrogen Therapy Towards Acute Ischemic Stroke

(2021) Shuanghu Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Monitoring the Fluctuation of Hydrogen Peroxide in Diabetes and Its Complications with a Novel Near-Infrared Fluorescent Probe

(2021) Wen-Xin Wang et al.   ANALYTICAL CHEMISTRY

Cardiovascular risk factors and prevention: a perspective from developing countries

(2021) Koon K. Teo et al.   CANADIAN JOURNAL OF CARDIOLOGY

Glutathione-Mediated Nanomedicines for Cancer Diagnosis and Therapy

(2021) Yiming Ding et al.   CHEMICAL ENGINEERING JOURNAL

Multimodal Theranostic Cyanine-Conjugated Gadolinium(III) Complex for In Vivo Imaging of Amyloid-β in an Alzheimer’s Disease Mouse Model

(2021) Xueli Wang et al.   ACS Applied Materials & Interfaces

pH-Triggered Copper-Free Click Reaction-Mediated Micelle Aggregation for Enhanced Tumor Retention and Elevated Immuno–Chemotherapy against Melanoma

(2021) Miao Deng et al.   ACS Applied Materials & Interfaces

Treatment of Hepatic Fibrosis in Mice Based on Targeted Plasmonic Hyperthermia

(2021) Jordi Ribera et al.   ACS Nano

GSH‐Responsive Radiosensitizers with Deep Penetration Ability for Multimodal Imaging‐Guided Synergistic Radio‐Chemodynamic Cancer Therapy

(2021) Xiahui Lin et al.   ADVANCED FUNCTIONAL MATERIALS

Significantly Improving the Bioefficacy for Rheumatoid Arthritis with Supramolecular Nanoformulations

(2021) Chao Ma et al.   ADVANCED MATERIALS

A Cooperatively Activatable, DNA‐based Fluorescent Reporter for Imaging of Correlated Enzymatic Activities

(2021) Zetan Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glutathione and its precursors in cancer

(2021) Gloria Asantewaa et al.   CURRENT OPINION IN BIOTECHNOLOGY

Ratiometric Semiconducting Polymer Nanoparticle for Reliable Photoacoustic Imaging of Pneumonia-Induced Vulnerable Atherosclerotic Plaque in Vivo

(2021) Yuan Ma et al.   NANO LETTERS

Health beliefs associated with preventive behaviors against noncommunicable diseases

(2021) Tingjun Wang et al.   PATIENT EDUCATION AND COUNSELING

Harnessing X‐Ray Energy‐Dependent Attenuation of Bismuth‐Based Nanoprobes for Accurate Diagnosis of Liver Fibrosis

(2021) Shiman Wu et al.   Advanced Science

Biomimetic-Coated Nanoplatform with Lipid-Specific Imaging and ROS Responsiveness for Atherosclerosis-Targeted Theranostics

(2021) Boxuan Ma et al.   ACS Applied Materials & Interfaces

Sulfite‐Inserted MgAl Layered Double Hydroxides Loaded with Glucose Oxidase to Enable SO 2 ‐Mediated Synergistic Tumor Therapy

(2021) Qiang Chu et al.   ADVANCED FUNCTIONAL MATERIALS

Biomimetic and Bioinspired Intervention Strategies for the Treatment of Rheumatoid Arthritis

(2021) Yu Han et al.   ADVANCED FUNCTIONAL MATERIALS

Thermochemotherapy Meets Tissue Engineering for Rheumatoid Arthritis Treatment

(2021) Fangli Gang et al.   ADVANCED FUNCTIONAL MATERIALS

Innovations in Disease State Responsive Soft Materials for Targeting Extracellular Stimuli Associated with Cancer, Cardiovascular Disease, Diabetes, and Beyond

(2021) Claudia Battistella et al.   ADVANCED MATERIALS

A Tumor‐Microenvironment‐Responsive Nanocomposite for Hydrogen Sulfide Gas and Trimodal‐Enhanced Enzyme Dynamic Therapy

(2021) Bin Liu et al.   ADVANCED MATERIALS

Furin-instructed aggregated gold nanoparticles for re-educating tumor associated macrophages and overcoming breast cancer chemoresistance

(2021) Rou Xie et al.   BIOMATERIALS

Ultrathin chalcogenide nanosheets for photoacoustic imaging-guided synergistic photothermal/gas therapy

(2021) Jingjing Wu et al.   BIOMATERIALS

Amphiphilic Distyrylbenzene Derivatives as Potential Therapeutic and Imaging Agents for Soluble and Insoluble Amyloid β Aggregates in Alzheimer’s Disease

(2021) Liang Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chronic kidney disease

(2021) Kamyar Kalantar-Zadeh et al.   LANCET

NIR‐II Photoacoustic Reporter for Biopsy‐Free and Real‐Time Assessment of Wilson's Disease

(2021) Qinrui Fu et al.   Small

Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy

(2021) Xing Qin et al.   Nature Communications

A Pilot Study: Hypertension, Endothelial Dysfunction and Retinal Microvasculature in Rheumatic Autoimmune Diseases

(2021) Ahmed Mahdy et al.   Journal of Clinical Medicine

Biomimetic Hybrid Membrane-Coated Xuetongsu Assisted with Laser Irradiation for Efficient Rheumatoid Arthritis Therapy

(2021) Huanghe Yu et al.   ACS Nano

Hydrogenated Oxide Material for Self‐Targeting and Automatic‐Degrading Photothermal Tumor Therapy in the NIR‐II Bio‐Window

(2021) Qing Zhu et al.   ADVANCED FUNCTIONAL MATERIALS

Ischemic Microenvironment‐Responsive Therapeutics for Cardiovascular Diseases

(2021) Xi Li et al.   ADVANCED MATERIALS

Precise Subcellular Organelle Targeting for Boosting Endogenous‐Stimuli‐Mediated Tumor Therapy

(2021) Wenyao Zhen et al.   ADVANCED MATERIALS

Conquering the Hypoxia Limitation for Photodynamic Therapy

(2021) Yilin Wan et al.   ADVANCED MATERIALS

An Activatable Hybrid Organic–Inorganic Nanocomposite as Early Evaluation System of Therapy Effect

(2021) Qinrui Fu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cardiovascular Imaging and Pregnancy

(2021) Jonathan Windram et al.   CANADIAN JOURNAL OF CARDIOLOGY

Activatable fluorescent probes for in situ imaging of enzymes

(2021) Xiaofeng Wu et al.   CHEMICAL SOCIETY REVIEWS

An Activatable Near-Infrared Fluorescence Probe for in Vivo Imaging of Acute Kidney Injury by Targeting Phosphatidylserine and Caspase-3

(2021) Jianhui Weng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Poly-β-cyclodextrin Supramolecular Nanoassembly with a pH-Sensitive Switch Removing Lysosomal Cholesterol Crystals for Antiatherosclerosis

(2021) Yan Zhang et al.   NANO LETTERS

Nanoengineered therapy aiming at the etiology of rheumatoid arthritis

(2021) Ruiqi Li et al.   Nano Today

Rheumatoid arthritis microenvironment insights into treatment effect of nanomaterials

(2021) Yan Zhu et al.   Nano Today

Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

(2021) Wei Chen et al.   Nature Reviews Cardiology

Optical Imaging in the Second Near Infrared Window for Vascular Bioimaging

(2021) Zi'an Wang et al.   Small

Multi‐Pathway Microenvironment Regulation for Atherosclerosis Therapy Based on Beta‐Cyclodextrin/L‐Arginine/Au Nanomotors with Dual‐Mode Propulsion

(2021) Ziyu Wu et al.   Small

Recent advances in upconversion nanoparticle-based nanocomposites for gas therapy

(2021) Nailin Yang et al.   Chemical Science

Hemodynamic molecular imaging of tumor-associated enzyme activity in the living brain

(2021) Mitul Desai et al.   eLife

Nanotechnology for Targeted Therapy of Atherosclerosis

(2021) Seyedmehdi Hossaini Nasr et al.   Frontiers in Pharmacology

pH and Glutathione Synergistically Triggered Release and Self-Assembly of Au Nanospheres for Tumor Theranostics

(2020) Lu An et al.   ACS Applied Materials & Interfaces

A Self-Assembled α-Synuclein Nanoscavenger for Parkinson’s Disease

(2020) Jingyi Liu et al.   ACS Nano

Activatable Molecular Probes for Second Near-Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging

(2020) Kanyi Pu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanodiagnostic Attainments and Clinical Perspectives on C-Reactive Protein: Cardiovascular Disease Risks Assessment

(2020) Iswary Letchumanan et al.   CURRENT MEDICINAL CHEMISTRY

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Nanodrug with ROS and pH Dual‐Sensitivity Ameliorates Liver Fibrosis via Multicellular Regulation

(2020) Liteng Lin et al.   Advanced Science

Autism spectrum disorder

(2020) Catherine Lord et al.   Nature Reviews Disease Primers

Ultra-efficient Antibacterial System Based on Photodynamic Therapy and CO Gas Therapy for Synergistic Antibacterial and Ablation Biofilms

(2020) Wei Ma et al.   ACS Applied Materials & Interfaces

NIR-Driven Water Splitting H2 Production Nanoplatform for H2-Mediated Cascade-Amplifying Synergetic Cancer Therapy

(2020) Qi Wang et al.   ACS Applied Materials & Interfaces

Affinity-Driven Design of Cargo-Switching Nanoparticles to Leverage a Cholesterol-Rich Microenvironment for Atherosclerosis Therapy

(2020) Heegon Kim et al.   ACS Nano

A pocket-escaping design to prevent the common interference with near-infrared fluorescent probes in vivo

(2020) Panfei Xing et al.   Nature Communications

Programmable ROS‐Mediated Cancer Therapy via Magneto‐Inductions

(2020) Jiaojiao Wu et al.   Advanced Science

A Self-Evaluating Photothermal Therapeutic Nanoparticle

(2020) Yanfang Wang et al.   ACS Nano

Acid‐Activatable Transmorphic Peptide‐Based Nanomaterials for Photodynamic Therapy

(2020) Bingbing Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Wilson disease

(2020) Annu Aggarwal et al.   CURRENT OPINION IN NEUROLOGY

ROS Homeostasis in Abiotic Stress Tolerance in Plants

(2020) Kalaivani K. Nadarajah   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advances in Functional and Molecular MRI Technologies in Chronic Liver Diseases

(2020) Iris Y. Zhou et al.   JOURNAL OF HEPATOLOGY

Early stratification of radiotherapy response by activatable inflammation magnetic resonance imaging

(2020) Zijian Zhou et al.   Nature Communications

Nutrition, Microbiota and Noncommunicable Diseases

(2020) Julio Plaza-Diaz   Nutrients

Nanomedicine Approaches for Advanced Diagnosis and Treatment of Atherosclerosis and Related Ischemic Diseases

(2020) Bin Hu et al.   Advanced Healthcare Materials

A Novel Targeted and High‐Efficiency Nanosystem for Combinational Therapy for Alzheimer's Disease

(2020) Han Yang et al.   Advanced Science

Detecting liver disease via an endogenous pigment

(2020) Justin J. O’Sullivan et al.   Nature Biomedical Engineering

Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin

(2020) Mari Saif et al.   Nature Biomedical Engineering

Furin‐Instructed Intracellular Gold Nanoparticle Aggregation for Tumor Photothermal Therapy

(2020) Jihua Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Site‐Specific MicroRNA‐33 Antagonism by pH‐Responsive Nanotherapies for Treatment of Atherosclerosis via Regulating Cholesterol Efflux and Adaptive Immunity

(2020) Chenwen Li et al.   ADVANCED FUNCTIONAL MATERIALS

An NIR‐II‐Emissive Photosensitizer for Hypoxia‐Tolerant Photodynamic Theranostics

(2020) Lanqing Li et al.   ADVANCED MATERIALS

An Ester‐Substituted Semiconducting Polymer with Efficient Nonradiative Decay Enhances NIR‐II Photoacoustic Performance for Monitoring of Tumor Growth

(2020) Menglei Zha et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Breathing Micelles for Combinatorial Treatment of Rheumatoid Arthritis

(2020) Siyue Tao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The tumor microenvironment

(2020) Nicole M. Anderson et al.   CURRENT BIOLOGY

ROS Responsive Nanoplatform with Two‐Photon AIE Imaging for Atherosclerosis Diagnosis and “Two‐Pronged” Therapy

(2020) Boxuan Ma et al.   Small

Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death

(2020) Hongzhang Deng et al.   Nature Communications

Alterations of the Human Gut Microbiome in Chronic Kidney Disease

(2020) Zhigang Ren et al.   Advanced Science

Polymeric Nanoparticles with ROS‐Responsive Prodrug and Platinum Nanozyme for Enhanced Chemophotodynamic Therapy of Colon Cancer

(2020) Ying Hao et al.   Advanced Science

Role of Glutathione in Cancer: From Mechanisms to Therapies

(2020) Luke Kennedy et al.   Biomolecules

Tumor-Specific Activatable Nanocarriers with Gas-Generation and Signal Amplification Capabilities for Tumor Theranostics

(2020) Chao Qi et al.   ACS Nano

Effective Eradication of Tumors by Enhancing Photoacoustic‐Imaging‐Guided Combined Photothermal Therapy and Ultrasonic Therapy

(2020) Caina Xu et al.   ADVANCED FUNCTIONAL MATERIALS

A Golgi-Targeting and Dual-Color “Turn-On” Probe for Spatially Precise Imaging of Furin

(2020) Xiao Hu et al.   ANALYTICAL CHEMISTRY

Furin‐Mediated Self‐Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors

(2020) Yue Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quantitative Mapping of Glutathione within Intracranial Tumors through Interlocked MRI Signals of a Responsive Nanoprobe

(2020) Peisen Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reactive Oxygen Species (ROS)-Responsive Prodrugs, Probes, and Theranostic Prodrugs: Applications in the ROS-Related Diseases

(2020) Pengfei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multifunctionalized Gold Sub‐Nanometer Particles for Sensitizing Radiotherapy against Glioblastoma

(2020) Cheng‐Yuan Dong et al.   Small

Stimuli-Responsive Plasmonic Assemblies and Their Biomedical Applications

(2020) Qinrui Fu et al.   Nano Today

A Noncovalent Fluorescence Turn-on Strategy for Hypoxia Imaging

(2019) Dong-Sheng Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular landmarks of tumor hypoxia across cancer types

(2019) Vinayak Bhandari et al.   NATURE GENETICS

Enhanced Radiosensitization by Gold Nanoparticles with Acid-Triggered Aggregation in Cancer Radiotherapy

(2019) Yumin Zhang et al.   Advanced Science

γ-Glutamyltranspeptidase-Triggered Intracellular Gadolinium Nanoparticle Formation Enhances the T2-Weighted MR Contrast of Tumor

(2019) Zijuan Hai et al.   NANO LETTERS

CARDIOVASCULAR DISEASE BURDEN OF INFLUENZA SYNDROME: NATIONAL TRENDS AND OUTCOMES FROM A UNITED STATES POPULATION STUDY FROM 2011 TO 2014

(2019) Ayush Arora et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques

(2019) Yudai Narita et al.   JOURNAL OF CONTROLLED RELEASE

Programming Stimuli-Responsive Behavior into Biomaterials

(2019) Barry A. Badeau et al.   Annual Review of Biomedical Engineering

Photoacoustic Imaging of Nanoparticle Transport in the Kidneys at High Temporal Resolution

(2019) Xingya Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selectively Potentiating Hypoxia Levels by Combretastatin A4 Nanomedicine: Toward Highly Enhanced Hypoxia-Activated Prodrug Tirapazamine Therapy for Metastatic Tumors

(2019) Shengcai Yang et al.   ADVANCED MATERIALS

Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy

(2019) Lu Liu et al.   ACS Nano

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

(2019) Min Zhu et al.   CELL

Reactive Oxygen Species (ROS)-Based Nanomedicine

(2019) Bowen Yang et al.   CHEMICAL REVIEWS

Stimulus-responsive nanoscale delivery systems triggered by the enzymes in the tumor microenvironment

(2019) Zhen-Tao Zhang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Photoacoustic imaging in the second near-infrared window: a review

(2019) Paul Kumar Upputuri et al.   JOURNAL OF BIOMEDICAL OPTICS

Engineering Biomimetic Platesomes for pH‐Responsive Drug Delivery and Enhanced Antitumor Activity

(2019) Guangna Liu et al.   ADVANCED MATERIALS

Activatable Small-Molecule Photoacoustic Probes that Cross the Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer's Disease

(2019) Shichao Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo

(2019) Namini N. Paranawithana et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomimetic Hybrid Nanozymes with Self-Supplied H+ and Accelerated O2 Generation for Enhanced Starvation and Photodynamic Therapy against Hypoxic Tumors

(2019) Xue Yang et al.   NANO LETTERS

Microvesicles: ROS scavengers and ROS producers

(2019) G. Bodega et al.   Journal of Extracellular Vesicles

In Vivo Quantitative Photoacoustic Diagnosis of Gastric and Intestinal Dysfunctions with a Broad pH-Responsive Sensor

(2019) Wenchao Huang et al.   ACS Nano

Gas-Mediated Cancer Bioimaging and Therapy

(2019) Lichan Chen et al.   ACS Nano

Noninvasive Imaging to Assess Atherosclerotic Plaque Composition and Disease Activity

(2019) Marwa Daghem et al.   JACC-Cardiovascular Imaging

Noninvasive monitoring of chronic kidney disease using pH and perfusion imaging

(2019) KowsalyaDevi Pavuluri et al.   Science Advances

Furin-Guided Intracellular 68Ga Nanoparticle Formation Enhancing Tumor MicroPET Imaging

(2019) Hongyong Wang et al.   ANALYTICAL CHEMISTRY

Stimuli-responsive Biomolecule-based Hydrogels and their Applications

(2019) Margarita Vázquez-González et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mo2 C-Derived Polyoxometalate for NIR-II Photoacoustic Imaging-Guided Chemodynamic/Photothermal Synergistic Therapy

(2019) Gongyuan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy

(2019) Yue Yuan et al.   NATURE MATERIALS

Early detection and staging of chronic liver diseases with a protein MRI contrast agent

(2019) Mani Salarian et al.   Nature Communications

Reactive Oxygen Correlated Chemiluminescent Imaging of a Semiconducting Polymer Nanoplatform for Monitoring Chemodynamic Therapy

(2019) Youjuan Wang et al.   NANO LETTERS

Easy-to-Use Colorimetric Cyanine Probe for the Detection of Cu2+ in Wilson’s Disease

(2018) Yibing Shi et al.   ACS Applied Materials & Interfaces

Glutathione-Responsive Self-Assembled Magnetic Gold Nanowreath for Enhanced Tumor Imaging and Imaging-Guided Photothermal Therapy

(2018) Yijing Liu et al.   ACS Nano

Nanomaterials in Neural-Stem-Cell-Mediated Regenerative Medicine: Imaging and Treatment of Neurological Diseases

(2018) Bingbo Zhang et al.   ADVANCED MATERIALS

Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo

(2018) Zhen Yang et al.   ADVANCED MATERIALS

Smart Dual Quenching Strategy Enhances the Detection Sensitivity of Intracellular Furin

(2018) Zijuan Hai et al.   ANALYTICAL CHEMISTRY

Targeting Oxidative Stress Using Nanoparticles as a Theranostic Strategy for Cardiovascular Diseases

(2018) Kye S. Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Ratiometric optical nanoprobes enable accurate molecular detection and imaging

(2018) Xiaolin Huang et al.   CHEMICAL SOCIETY REVIEWS

Glutathione metabolism in cancer progression and treatment resistance

(2018) Ankita Bansal et al.   JOURNAL OF CELL BIOLOGY

Nanomedicine for tumor microenvironment modulation and cancer treatment enhancement

(2018) Jingjing Liu et al.   Nano Today

Aggregation induced photoacoustic detection of mercury (Ⅱ) ions using quaternary ammonium group-capped gold nanorods

(2018) Yan Huang et al.   TALANTA

Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type 1 diabetes progression in preclinical models

(2018) Joshua R. St Clair et al.   Nature Communications

Rapid Response Fluorescence Probe Enabled In Vivo Diagnosis and Assessing Treatment Response of Hypochlorous Acid-Mediated Rheumatoid Arthritis

(2018) Huan Feng et al.   Advanced Science

Gas-Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

(2018) Luodan Yu et al.   ADVANCED MATERIALS

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

(2018) Denzil Furtado et al.   ADVANCED MATERIALS

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Enzyme-triggered self-assembly of gold nanoparticles for enhanced retention effects and photothermal therapy of prostate cancer

(2018) Shuyan Yang et al.   CHEMICAL COMMUNICATIONS

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

(2018) Masha G. Savelieff et al.   CHEMICAL REVIEWS

Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016

(2018) Yan Xie et al.   KIDNEY INTERNATIONAL

Stimulus-responsive gold nanotheranostic platforms for targeting the tumor microenvironment

(2018) Jun Jin et al.   Nano Today

Peptide secretion triggers diabetes

(2018) Jiajie Wei et al.   NATURE

Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches

(2018) Julian Bejarano et al.   Theranostics

Optical Nanoparticles for Cardiovascular Imaging

(2018) Jie Hu et al.   Advanced Optical Materials

Wilson disease

(2018) Anna Członkowska et al.   Nature Reviews Disease Primers

Wilson disease

(2018)   Nature Reviews Disease Primers

Magnetic Targeting, Tumor Microenvironment-Responsive Intelligent Nanocatalysts for Enhanced Tumor Ablation

(2018) Lili Feng et al.   ACS Nano

Progressive release of mesoporous nano-selenium delivery system for the multi-channel synergistic treatment of Alzheimer's disease

(2018) Jing Sun et al.   BIOMATERIALS

Stimuli-Responsive Therapeutic Metallodrugs

(2018) Xiaohui Wang et al.   CHEMICAL REVIEWS

Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016–40 for 195 countries and territories

(2018) Kyle J Foreman et al.   LANCET

Local generation of hydrogen for enhanced photothermal therapy

(2018) Penghe Zhao et al.   Nature Communications

ROS-induced ROS release in plant and animal cells

(2017) Sara I. Zandalinas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calcium Sensor for Photoacoustic Imaging

(2017) Sheryl Roberts et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ratiometric pH Imaging with a CoII2 MRI Probe via CEST Effects of Opposing pH Dependences

(2017) Agnes E. Thorarinsdottir et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhinovirus – From bench to bedside

(2017) Kelvin K.W. To et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

(2017) Tetsuhiro Kikuchi et al.   NATURE

Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis

(2017) Longwei Liu et al.   NATURE MATERIALS

Recent Advances in Managing Atherosclerosis via Nanomedicine

(2017) Cecilia Ka Wing Chan et al.   Small

Manganese Dioxide Coated WS2 @Fe3 O4 /sSiO2 Nanocomposites for pH-Responsive MR Imaging and Oxygen-Elevated Synergetic Therapy

(2017) Guangbao Yang et al.   Small

Gold nanoparticles in cardiovascular imaging

(2017) Mariana Varna et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Ratiometric photoacoustic imaging of endoplasmic reticulum polarity in injured liver tissues of diabetic mice

(2017) Haibin Xiao et al.   Chemical Science

In vivo quantitative imaging of tumor pH by nanosonophore assisted multispectral photoacoustic imaging

(2017) Janggun Jo et al.   Nature Communications

A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia

(2017) Hailey J. Knox et al.   Nature Communications

Ultra-small pH-responsive Nd-doped NaDyF4 Nanoagents for Enhanced Cancer Theranostic by in situ Aggregation

(2017) Yuxin Liu et al.   Theranostics

Increased Gold Nanoparticle Retention in Brain Tumors by in Situ Enzyme-Induced Aggregation

(2016) Shaobo Ruan et al.   ACS Nano

Near-Infrared Upconversion Chemodosimeter for In Vivo Detection of Cu2+in Wilson Disease

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A new class of fast-response and highly selective fluorescent probes for visualizing peroxynitrite in live cells, subcellular organelles, and kidney tissue of diabetic rats

(2016) Junfeng Miao et al.   BIOMATERIALS

Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer

(2016) Monika Wierdl et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

(2016) Zijian Zhou et al.   CHEMICAL SOCIETY REVIEWS

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Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson’s Disease

(2016) Sumin Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy

(2016) Hyunjae Lee et al.   Nature Nanotechnology

A Functional CT Contrast Agent for In Vivo Imaging of Tumor Hypoxia

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In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics

(2016) Xiangzhao Ai et al.   Nature Communications

Bioresponsive materials

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A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease

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A Single Biosensor for Evaluating the Levels of Copper Ion andL-Cysteine in a Live Rat Brain with Alzheimer's Disease

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Type 2 Diabetes Mellitus: Limitations of Conventional Therapies and Intervention with Nucleic Acid-Based Therapeutics

(2015) Ganesh R. Kokil et al.   CHEMICAL REVIEWS

Prospective evaluation of the diagnostic accuracy of hepatic copper content, as determined using the entire core of a liver biopsy sample

(2015) Xu Yang et al.   HEPATOLOGY

Formation of 3D Cholesterol Crystals from 2D Nucleation Sites in Lipid Bilayer Membranes: Implications for Atherosclerosis

(2015) Neta Varsano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Wilson's disease and other neurological copper disorders

(2015) Oliver Bandmann et al.   LANCET NEUROLOGY

Redox distress and genetic defects conspire in systemic autoinflammatory diseases

(2015) Georg Varga et al.   Nature Reviews Rheumatology

An enzyme-responsive metal-enhanced near-infrared fluorescence sensor based on functionalized gold nanoparticles

(2015) Zhanghua Zeng et al.   Chemical Science

Stimuli-Responsive Polymeric Nanoparticles for Nanomedicine

(2014) Carina I. C. Crucho   ChemMedChem

Diagnostic Imaging Agents for Alzheimer’s Disease: Copper Radiopharmaceuticals that Target Aβ Plaques

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Activatable Oligomerizable Imaging Agents for Photoacoustic Imaging of Furin-Like Activity in Living Subjects

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Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Wilson's disease, 100 years later…

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Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

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Stimuli-responsive polymers: Biomedical applications and challenges for clinical translation

(2012) Allan S. Hoffman   ADVANCED DRUG DELIVERY REVIEWS

Glutathione levels in human tumors

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Physiological Roles of Mitochondrial Reactive Oxygen Species

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Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model

(2012) T. Hirayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates

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The role of glutathione in brain tumor drug resistance

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ATP7A-related copper transport diseases—emerging concepts and future trends

(2011) Stephen G. Kaler   Nature Reviews Neurology

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

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pH control mechanisms of tumor survival and growth

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Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

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Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

(2009) Leslie M. Shaw et al.   ANNALS OF NEUROLOGY

Global estimates of the prevalence of diabetes for 2010 and 2030

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Nanoparticles for Optical Molecular Imaging of Atherosclerosis

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Imaging of atherosclerotic cardiovascular disease

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