Article
Engineering, Biomedical
Martin Karl Schneider, James Wang, Aris Kare, Shaunak S. Adkar, Darren Salmi, Caitlin F. Bell, Tom Alsaigh, Dhananjay Wagh, John Coller, Aaron Mayer, Sarah J. Snyder, Alexander D. Borowsky, Steven R. Long, Maarten G. Lansberg, Gary K. Steinberg, Jeremy J. Heit, Nicholas J. Leeper, Katherine W. Ferrara
Summary: The study demonstrates the potential of near-infrared auto-photoacoustic (NIRAPA) imaging in detecting plaque components and differentiating stable and vulnerable plaques. The researchers also developed a methodology to combine molecular imaging with spatial transcriptomic and proteomic methods for a more comprehensive understanding of plaque characteristics.
Article
Engineering, Biomedical
Ming Zhang, Zhongjian Xie, Haijiao Long, Kun Ren, Lianjie Hou, Yu Wang, Xiaodan Xu, Weixing Lei, Zhicheng Yang, Shakeel Ahmed, Han Zhang, Guojun Zhao
Summary: Early delineation of vulnerable atherosclerotic plaques is crucial for prevention and treatment of cardio-cerebral vascular accidents. However, currently available imaging technologies have limitations. Nanoparticle technology is a promising diagnostic strategy for detecting hallmarks of vulnerable plaques.
MATERIALS TODAY BIO
(2022)
Article
Multidisciplinary Sciences
Jianwen Song, Xiaoying Kang, Lu Wang, Dan Ding, Deling Kong, Wen Li, Ji Qi
Summary: Researchers have developed a polymer nanoplatform for thrombus imaging and treatment in the near-infrared-II region, offering a versatile approach for the diagnosis and treatment of life-threatening diseases caused by thrombotic disorders.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Lili Teng, Xiaoyu Han, Yongchao Liu, Chang Lu, Baoli Yin, Shuangyan Huan, Xia Yin, Xiao-Bing Zhang, Guosheng Song
Summary: A novel nanozyme with oxidase-like activity was developed for acid-induced cancer therapy, utilizing ratiometric near-infrared fluorescence-photoacoustic molecular imaging to report its catalytic activity. The nanozyme showed excellent anticancer efficacy in the tumor microenvironment, and the ratiometric signals provided a new approach for predicting its efficacy in living systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Jianjian Zhang, Lulu Ning, Ziling Zeng, Kanyi Pu
Summary: Photoacoustic imaging in the NIR-II window offers deeper penetration and lower background noise compared to the NIR-I window. Contrast agents can be used to visualize biological processes at greater depths, and further development of activatable probes shows promise for biomarker detection in biomedical research. Potential challenges and prospects in the field of NIR-II PAI contrast agents are also discussed.
TRENDS IN CHEMISTRY
(2021)
Article
Materials Science, Biomaterials
Fang Liu, Feiyan Ma, Qing Chen, Enbao Zhou, Puwen Zhang, Zhanjun Cui, Zhonghua Liu, Yongwei Huang
Summary: This work synthesized a series of DPP derivatives containing chalcogen and fluorine atoms, revealing the synergistic pi-pi and van der Waals interactions can enhance photothermal performance. The DPP-SeF nanoagents show efficient tumor killing ability and excellent biocompatibility, indicating their potential as photoacoustic/PTT agents in cancer treatment. The study demonstrates the concept of utilizing non-bonding interactions to optimize antitumor efficiency through molecular engineering.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Wenhui Zeng, Luyan Wu, Yidan Sun, Yuqi Wang, Jinfang Wang, Deju Ye
Summary: The study developed a ratiometric fluorescent probe (SPN-MMP-RGD) by integrating Cy5.5 and PCPDTBT, enabling sensitive detection of MMP-2 activity and noninvasive imaging of tumor cells.
Article
Chemistry, Multidisciplinary
Guowei Deng, Hongyu Chen, Jiexue Wang, Kexiang Chen, Lu Li, Shilu Zhang, Kang Sun, Zhonghui Li, Jun Liu
Summary: This study developed a series of PTT agents based on D-pi-A-type chromophores with different electron-donating groups to optimize their photothermal performance. PTA-2-cRGD exhibited superior photothermal properties and complete tumor eradication without recurrence in vivo. The improved photothermal performance of PTA-2-cRGD also enhanced the photoacoustic signal, which was utilized for tumor diagnosis in vivo.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Multidisciplinary
Xuelong Huang, Ning Lan, Yanfeng Zhang, Wei Zeng, Haifeng He, Xiuhong Liu
Summary: This mini review summarizes the recent advances in the design strategy of semiconducting polymer nanoparticles based on benzo(1,2-c;4,5-c')bis(1,2,5)thiadiazole (BBT) and its derivatives for second near-infrared photoacoustic imaging.
FRONTIERS IN CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Xu Zhen, Kanyi Pu, Xiqun Jiang
Summary: The development of semiconducting polymer nanoparticles (SPNs) for photoacoustic imaging and photothermal therapy has shown promising results due to their clear structure-property relation and molecular structural tunability. Various strategies such as structure-property screening, fluorescence quenching, accelerated heat dissipation, and size-dependent heat dissipation have been discussed to amplify the PA brightness of SPNs for in vivo PA. Additionally, molecular approaches have been introduced to shift the absorption of SPNs for NIR-II PA imaging and PTT in order to improve tissue penetration depth for diagnosis and therapy.
Article
Materials Science, Multidisciplinary
Mengjun Zhu, Qiang Zhang, Xiaomei Dai, Junyong Sun, Feng Gao
Summary: A ratiometric semiconducting polymer dot-based fluorescent probe with dual-emission at blue and green regions, PFO-PFPV Pdot, has been developed for detecting and imaging HOCl in living cells. The probe showed high specificity and sensitivity, low cytotoxicity, and good biocompatibility for HOCl detection.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Qiang Zhang, Xiaoxiao Hu, Xiaomei Dai, Pinghua Ling, Junyong Sun, Hongqi Chen, Feng Gao
Summary: This study focuses on the design and synthesis of integrated polymers sensitive to hypochlorous acid (HClO), as well as the corresponding polymer-derived Pdots. These optimized Pdots exhibit unique characteristics including multiple fluorescence colors, fast response, low detection limit, and high selectivity for ClO- sensing. The integrated Pdots were successfully applied for two-photon ClO- imaging in cells and in acute inflammation in mice, showing promising results for bioapplications.
Review
Chemistry, Multidisciplinary
Zhenxiang Zhao, Chelsea B. Swartchick, Jefferson Chan
Summary: This article provides an overview of the application of photoacoustic (PA) imaging for high resolution visualization of biological processes within deep tissue. It discusses the selection of cancer biomarkers and the design of imaging agents for in vivo use, highlighting notable examples and future perspectives in the field.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Analytical
Zeshun Li, Tingting Li, Chen Zhang, Jen-Shyang Ni, Yaoyao Ji, Aihui Sun, Dinglu Peng, Weijun Wu, Lei Xi, Kai Li
Summary: The study designed near-infrared absorbing semiconducting polymer nanoparticles to track the targeting behaviors of cells to inflammation sites and revealed the cell types' activities in the inflammation microenvironment through photoacoustic activity.
ANALYTICAL CHEMISTRY
(2021)
Article
Physics, Applied
Avishek Das, Arthur C. M. V. Pereira, Anton A. Popov, Andrei Pastukhov, Sergei M. Klimentov, Andrei V. Kabashin, Anderson S. L. Gomes
Summary: Photoacoustic imaging (PAI) is a promising noninvasive biomedical diagnostic technique, but lacks efficient nano-sized contrast agents. Researchers found that titanium nitride (TiN) nanoparticles synthesized by pulsed laser ablation in liquids can be used as a contrast agent in PAI. These nanoparticles exhibit a strong nonlinear photoacoustic response and can generate high-resolution images.
APPLIED PHYSICS LETTERS
(2022)
Article
Chemistry, Analytical
Xuanhao Zhang, Qian Li, Qiqi Chao, Yuxi Zhang, Xufeng Sun, Gao-Chao Fan, Zhi Ling Song, Rongmei Kong, Xiliang Luo
Summary: In this study, a protein enzyme-free and general approach for sensitive detection of single nucleotide polymorphisms (SNPs) is developed using asymmetric MNAzyme probes. The multi-arm probe (MNAzyme-9M-13) with two asymmetric recognition arms is designed to detect EGFR T790 M mutation. Through a one-pot mixing, the probe enables the sensitive detection of the mutation without protein enzyme or multi-step operation. The strategy also shows potential for SNPs detection in long genomic sequences and short microRNAs.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Na Wu, Chang Lu, Youjuan Wang, Liuhui Liu, Dingyou Lu, Ying Zhou, Min He, Xiaobing Zhang, Guosheng Song
Summary: The total antioxidant capacity (TAC) is an important indicator of the body's ability to resist oxidative stress injury in diabetes. Currently, there is a lack of a simple and reliable method to detect TAC in diabetes. In this study, a novel chemiluminescent platform based on semiconducting polymer nanoparticles-manganese (SPNs-MnVII) is designed to detect the total antioxidant capacity of urine in diabetic mice.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Qian Li, Zhi-Ling Song, Yuxi Zhang, Lina Zhu, Qian Yang, Xingfu Liu, Xufeng Sun, Xuxu Chen, Rongmei Kong, Gao-Chao Fan, Xiliang Luo
Summary: A synergistic activator effect is discovered, where the incorporation of two short ssDNA activators can promote the trans-cleavage of CRISPR/Cas12a. This finding provides deeper insight into CRISPR/Cas12a and may facilitate its expanded application and exploration of other CRISPR/Cas systems.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Hengxin Shen, Shiyi Liao, Zhe Li, Youjuan Wang, Shuangyan Huan, Xiao-Bing Zhang, Guosheng Song
Summary: Organic afterglow nanoparticles are optical materials that emit light long after excitation. They have been widely used in various fields such as cell tracking, biosensing, cancer diagnosis, and therapy due to their advantages of no need for real-time excitation, low background, deep tissue penetration, and high sensitivity. This review summarizes the recent progress of organic afterglow imaging, focusing on the mechanism and biological application of these materials. The potential challenges and future directions of this field are also discussed.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Yongchao Liu, Lili Teng, Xiao-Feng Lou, Xiao-Bing Zhang, Guosheng Song
Summary: This study reports a novel hemicyanine-based molecule scaffold with stimuli-responsive afterglow luminescence, which can store photoenergy for delayed luminescence. Three modular activatable molecular afterglow probes (MAPs) are designed for the quantification and imaging of pH, superoxide anions, and aminopeptidase. MAPs show higher sensitivity in afterglow imaging than in fluorescence imaging due to the simultaneous control of fluorescence initiation and 1O2 generation by the responsive unit. MAPs are also applied for high-contrast afterglow imaging of drug-induced hepatotoxicity, allowing for early diagnosis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Yaqun Xu, Xiujuan Qiao, Zhi-Ling Song, Gao-Chao Fan, Xiliang Luo
Summary: A robust photoelectrochemical (PEC) biosensor capable of accurate detection in human serum was developed by integrating a new engineered branching peptide (EBP) into a synergetic dual-photoelectrode system. The biosensor exhibited high sensitivity, specificity, and anti-interference properties.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yuan Ma, Jinhui Shang, Liuhui Liu, Menghuan Li, Xinyu Xu, Hui Cao, Li Xu, Wei Sun, Guosheng Song, Xiao-Bing Zhang
Summary: Atherosclerotic plaque rupture, caused by the decomposition of fiber caps induced by cysteine cathepsin, is a significant cause of acute cardiovascular events. However, the accurate measurement of cathepsin B (CTB) activity in plaques is challenging due to the limitations of current fluorescent probes. To address this, a lipid-unlocked CTB responsive probe (L-CRP) was developed, which uses lipids and CTB as two keys to unlock photoacoustic signals for measuring CTB activity in lipophilic environments. L-CRP demonstrates reliable imaging of specific CTB activities in foam cells and atherosclerotic plaques, and exhibits deeper tissue penetration ability compared to current CTB probes. In atherosclerotic mice, L-CRP dynamically reports intraplaque CTB levels and enables risk stratification based on plaque vulnerability characteristics. L-CRP also successfully identifies atherosclerotic plaques in excised human artery tissues, showing promise for auxiliary diagnosis in clinical applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Lingling Lei, Fengrui Yang, Xin Meng, Li Xu, Peng Liang, Yuan Ma, Zhe Dong, Youjuan Wang, Xiao-Bing Zhang, Guosheng Song
Summary: This study presents a unique afterglow molecular scaffold based on hemicyanine and rhodamine dyes, which shows promise for low-background optical imaging. Compared to previous designs, this scaffold exhibits responsive OFF-ON afterglow signals and offers advantages such as a larger dynamic range and higher sensitivity. The integration of multiple functionalities simplifies probe design and enhances reliability. Additionally, the researchers have developed various probes for different molecular targets, expanding the applications of this afterglow molecular scaffold.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Baode Chen, Liuhui Liu, Renye Yue, Zhe Dong, Chang Lu, Cheng Zhang, Guoqiang Guan, Huiyi Liu, Qingpeng Zhang, Guosheng Song
Summary: With the advancement in MRI technology, traditional contrast agents struggle to meet accuracy imaging demands, but novel dual-mode contrast agents with T1-T2 ability provide better imaging applications and improved accuracy. Responsive MRI probes, unlike traditional agents, change signals in response to stimuli, leading to highly selective and excellent contrast effects. This review focuses on responsive and switchable MRI probe types, highlighting their mechanism, application in tumor imaging, and future development trends and challenges.
Review
Nanoscience & Nanotechnology
Qinpeng Zhang, Rui Yin, Guoqiang Guan, Huiyi Liu, Guosheng Song
Summary: This review provides an overview of recent advancements in the development of renal-clearable magnetic nanoparticles (MNPs) for disease imaging and treatment. Factors influencing renal clearance, types of renal-clearable MNPs, synthesis methods, and biomedical applications are discussed.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Chang Lu, Zhe Li, Na Wu, Dingyou Lu, Xiao-Bing Zhang, Guosheng Song
Summary: Acidity-stimulated platforms have the potential to improve cancer imaging and therapy within the tumor microenvironment. This study developed a novel companion diagnostic system, core-satellite semiconducting polymer nanoparticles @ cobalt hydroxide oxide (SPNs@CoOOH), tailored to tumor microenvironments. The pH-responsive range of SPNs@CoOOH can be regulated to achieve efficient and precise tumor treatment, minimizing non-specific activation in normal tissue and off-targeted toxicity risks. The chemiluminescence from SPNs@CoOOH correlates well with the generation of (1)O(2) under different conditions, showing good relevance with cancer inhibition rates in vivo.
Review
Multidisciplinary Sciences
Shiyi Liao, Mengjie Zhou, Youjuan Wang, Chang Lu, Baoli Yin, Ying Zhang, Huiyi Liu, Xia Yin, Guosheng Song
Summary: Tumor heterogeneity leads to individual variations in tumor microenvironments, causing poor prognoses and limited therapeutic response. Companion diagnostics (CDx) can detect biomarkers and monitor therapeutic responses, helping identify patients who benefit most from treatment. However, current FDA-approved CDx tests mainly detect biomarkers in vitro and ex vivo, making it challenging to report real-time variations of targets in vivo. Medical imaging techniques provide dynamic measurement of tumor heterogeneity and treatment response, complementing CDx tests. Imaging-based companion diagnostics allow patient stratification for targeted medicines and identification of patient populations benefiting from alternative therapies. This review summarizes recent developments in molecular imaging for predicting and assessing responses to cancer therapies and the various biomarkers used in imaging-based CDx tests, aiming to advance precision medicine.
Article
Chemistry, Analytical
Na Wu, Chang Lu, Youjuan Wang, Liuhui Liu, Dingyou Lu, Ying Zhou, Min He, Xiaobing Zhang, Guosheng Song
Summary: A novel chemiluminescent platform based on semiconducting polymer nanoparticles-manganese (SPNs-MnVII) was designed to detect the total antioxidant capacity of urine in diabetic mice. The chemiluminescent tool of SPNs (PFODBT)-MnVII is convenient, efficient, and sensitive, and shows promise for monitoring antioxidant therapy of diabetes.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Zhiming Deng, Dingyou Lu, Sulai Liu, Xianzheng Tan, Guosheng Song
Summary: Disorder of metal ion levels can significantly impact the ecological environment and human health. Traditional detection methods have limitations in monitoring the physiological distribution of metal ions with high sensitivity. Magnetic resonance imaging (MRI) has been widely used to design and develop MRI nanoprobes for metal ion detection. This review highlights the research progress, limitations, and challenges in the development of MRI-based metal ion detection probes.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Analytical
Yaqun Xu, Xiujuan Qiao, Zhi-Ling Song, Gao-Chao Fan, Xiliang Luo
Summary: In this study, a robust photoelectrochemical (PEC) biosensor capable of accurate detection in human serum was developed by integrating a new engineered branching peptide (EBP) into a synergetic dual-photoelectrode system. The EBP, serving as a dual-functional antifouling and recognition probe, showed enhanced antifouling properties compared to a regular linear peptide (LP). The PEC biosensor demonstrated high sensitivity, specificity, and anti-interference in detecting the cardiac troponin I biomarker.
ANALYTICAL CHEMISTRY
(2023)