Recent Advances in Managing Atherosclerosis via Nanomedicine

Animal models of atherosclerosis

(2017) Besa Emini Veseli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation

(2017) Sandeep Kumar et al.   LABORATORY INVESTIGATION

Near-infrared fluorophores for biomedical imaging

(2017) Guosong Hong et al.   Nature Biomedical Engineering

Tailoring Nanostructure Morphology for Enhanced Targeting of Dendritic Cells in Atherosclerosis

(2016) Sijia Yi et al.   ACS Nano

High-Density Lipoproteins: Nature’s Multifunctional Nanoparticles

(2016) Rui Kuai et al.   ACS Nano

Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis

(2016) Nazila Kamaly et al.   ACS Nano

Pioglitazone-Incorporated Nanoparticles Prevent Plaque Destabilization and Rupture by Regulating Monocyte/Macrophage Differentiation inApoE−/−MiceSignificance

(2016) Soichi Nakashiro et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Labeling monocytes with gold nanoparticles to track their recruitment in atherosclerosis with computed tomography

(2016) Peter Chhour et al.   BIOMATERIALS

Reduction of Atherosclerotic Lesions by the Chemotherapeutic Agent Carmustine Associated to Lipid Nanoparticles

(2016) Elaine N. Daminelli et al.   CARDIOVASCULAR DRUGS AND THERAPY

Necrotic Cell Sensor Clec4e Promotes a Proatherogenic Macrophage Phenotype Through Activation of the Unfolded Protein ResponseClinical Perspective

(2016) Marc Clément et al.   CIRCULATION

ORP4L Facilitates Macrophage Survival via G-Protein–Coupled SignalingNovelty and Significance

(2016) Wenbin Zhong et al.   CIRCULATION RESEARCH

PET/CT Imaging of Chemokine Receptors in Inflammatory Atherosclerosis Using Targeted Nanoparticles

(2016) H. P. Luehmann et al.   JOURNAL OF NUCLEAR MEDICINE

Adequately-Sized Nanocarriers Allow Sustained Targeted Drug Delivery to Neointimal Lesions in Rat Arteries

(2016) Ryosuke Taniguchi et al.   MOLECULAR PHARMACEUTICS

In Vivo Targeting and Imaging of Atherosclerosis Using Multifunctional Virus-Like Particles of Simian Virus 40

(2016) Xianxun Sun et al.   NANO LETTERS

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

(2016) Yoko Kojima et al.   NATURE

Immune cell screening of a nanoparticle library improves atherosclerosis therapy

(2016) Jun Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved sensitivity of computed tomography towards iodine and gold nanoparticle contrast agents via iterative reconstruction methods

(2016) Ally Leigh Bernstein et al.   Scientific Reports

In vivo MR and Fluorescence Dual-modality Imaging of Atherosclerosis Characteristics in Mice Using Profilin-1 Targeted Magnetic Nanoparticles

(2016) Yabin Wang et al.   Theranostics

Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

(2016) Yuri V. Bobryshev et al.   Biomed Research International

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Detection of Vulnerable Atherosclerosis Plaques with a Dual-Modal Single-Photon-Emission Computed Tomography/Magnetic Resonance Imaging Probe Targeting Apoptotic Macrophages

(2015) Dengfeng Cheng et al.   ACS Applied Materials & Interfaces

Atherosclerotic Plaque Targeting Mechanism of Long-Circulating Nanoparticles Established by Multimodal Imaging

(2015) Mark E. Lobatto et al.   ACS Nano

Multifunctional Nanoparticles Facilitate Molecular Targeting and miRNA Delivery to Inhibit Atherosclerosis in ApoE–/– Mice

(2015) Azadeh Kheirolomoom et al.   ACS Nano

HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages

(2015) Brenda L. Sanchez-Gaytan et al.   BIOCONJUGATE CHEMISTRY

Hyaluronic acid nanoparticles for active targeting atherosclerosis

(2015) Ga Young Lee et al.   BIOMATERIALS

Improved intervention of atherosclerosis and cardiac hypertrophy through biodegradable polymer-encapsulated delivery of glycosphingolipid inhibitor

(2015) S. Mishra et al.   BIOMATERIALS

Rodent models for human diseases

(2015) Thierry F. Vandamme   EUROPEAN JOURNAL OF PHARMACOLOGY

Quantifying progression and regression of thrombotic risk in experimental atherosclerosis

(2015) Rohun U. Palekar et al.   FASEB JOURNAL

Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis

(2015) Charis Costopoulos et al.   INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING

Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration

(2015) Fleur M. van der Valk et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoparticles functionalised with an anti-platelet human antibody for in vivo detection of atherosclerotic plaque by magnetic resonance imaging

(2015) Marie-Josée Jacobin-Valat et al.   Nanomedicine-Nanotechnology Biology and Medicine

Silica–gold nanoparticles for atheroprotective management of plaques: results of the NANOM-FIM trial

(2015) Alexander N. Kharlamov et al.   Nanoscale

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo

(2015) Daniel R. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

(2015) Gabrielle Fredman et al.   Science Translational Medicine

Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation

(2015) J. Tang et al.   Science Advances

Identifying Vulnerable Atherosclerotic Plaque in Rabbits Using DMSA-USPIO Enhanced Magnetic Resonance Imaging to Investigate the Effect of Atorvastatin

(2015) Chunmei Qi et al.   PLoS One

Ultrasmall NaGdF4Nanodots for Efficient MR Angiography and Atherosclerotic Plaque Imaging

(2014) Huaiyong Xing et al.   ADVANCED MATERIALS

Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

(2014) Leslie A. Lange et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Active targeting of early and mid-stage atherosclerotic plaques using self-assembled peptide amphiphile micelles

(2014) Laurie B. Mlinar et al.   BIOMATERIALS

Induction of Atherosclerosis in Mice and Hamsters Without Germline Genetic Engineering

(2014) Martin Mæng Bjørklund et al.   CIRCULATION RESEARCH

In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I

(2014) Yannan Zhao et al.   JOURNAL OF LIPID RESEARCH

Amphiphilic Nanoparticles Repress Macrophage Atherogenesis: Novel Core/Shell Designs for Scavenger Receptor Targeting and Down-Regulation

(2014) Latrisha K. Petersen et al.   MOLECULAR PHARMACEUTICS

Dual-Modal Magnetic Resonance and Fluorescence Imaging of Atherosclerotic Plaques in Vivo Using VCAM-1 Targeted Tobacco Mosaic Virus

(2014) Michael A. Bruckman et al.   NANO LETTERS

PET imaging of inflammation in atherosclerosis

(2014) Jason M. Tarkin et al.   Nature Reviews Cardiology

Monocyte-Targeting Supramolecular Micellar Assemblies: A Molecular Diagnostic Tool for Atherosclerosis

(2014) Eun Ji Chung et al.   Advanced Healthcare Materials

Gold Nanocrystal Labeling Allows Low-Density Lipoprotein Imaging from the Subcellular to Macroscopic Level

(2013) Iris E. Allijn et al.   ACS Nano

Neuroimmune Guidance Cue Semaphorin 3E Is Expressed in Atherosclerotic Plaques and Regulates Macrophage Retention

(2013) Amarylis Wanschel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nanoparticle-Mediated Delivery of Pitavastatin Inhibits Atherosclerotic Plaque Destabilization/Rupture in Mice by Regulating the Recruitment of Inflammatory Monocytes

(2013) Shunsuke Katsuki et al.   CIRCULATION

Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques

(2013) Maulik D. Majmudar et al.   CIRCULATION RESEARCH

Molecular MRI of Atherosclerosis

(2013) Alkystis Phinikaridou et al.   MOLECULES

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

(2013) Stefan Freigang et al.   NATURE IMMUNOLOGY

Statins in the primary prevention of cardiovascular disease

(2013) Željko Reiner   Nature Reviews Cardiology

Biodegradable synthetic high-density lipoprotein nanoparticles for atherosclerosis

(2013) Sean Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Atherosclerotic calcification relates to cognitive function and to brain changes on magnetic resonance imaging

(2012) Daniel Bos et al.   Alzheimers & Dementia

Animal Models of Atherosclerosis

(2012) Godfrey S. Getz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pioglitazone Slows Progression of Atherosclerosis in Prediabetes Independent of Changes in Cardiovascular Risk Factors

(2012) Aramesh Saremi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

Ultrasmall Superparamagnetic Particles of Iron Oxide in Patients With Acute Myocardial Infarction

(2012) Shirjel R. Alam et al.   Circulation-Cardiovascular Imaging

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

(2012) Wahajuddin et al.   International Journal of Nanomedicine

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

OxLDL-targeted iron oxide nanoparticles for in vivo MRI detection of perivascular carotid collar induced atherosclerotic lesions in ApoE-deficient mice

(2012) Song Wen et al.   JOURNAL OF LIPID RESEARCH

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

(2012) Janine M van Gils et al.   NATURE IMMUNOLOGY

Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane

(2012) J. E. Zuckerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels

(2012) N. Korin et al.   SCIENCE

Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe–/– mice during disease regression

(2011) Stephane Potteaux et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of Hyaluronic Acid in Atherosclerosis and Intimal Hyperplasia

(2011) Benjamin Sadowitz et al.   JOURNAL OF SURGICAL RESEARCH

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid-polymeric nanoparticles

(2011) J. M. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice

(2011) J. Hamzah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Annexin A5-Functionalized Bimodal Nanoparticles for MRI and Fluorescence Imaging of Atherosclerotic Plaques

(2010) Geralda A. F. van Tilborg et al.   BIOCONJUGATE CHEMISTRY

Hyaluronic Acid Immobilized Magnetic Nanoparticles for Active Targeting and Imaging of Macrophages

(2010) Medha Kamat et al.   BIOCONJUGATE CHEMISTRY

Cardiac Positron Emission Tomography/Computed Tomography Imaging Accurately Detects Anatomically and Functionally Significant Coronary Artery Disease

(2010) S. Kajander et al.   CIRCULATION

Multimodal Clinical Imaging To Longitudinally Assess a Nanomedical Anti-Inflammatory Treatment in Experimental Atherosclerosis

(2010) Mark E. Lobatto et al.   MOLECULAR PHARMACEUTICS

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Nanomedicine

(2010) Betty Y.S. Kim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Spatiotemporal controlled delivery of nanoparticles to injured vasculature

(2010) J. M. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atherosclerotic Plaque Composition: Analysis with Multicolor CT and Targeted Gold Nanoparticles

(2010) David P. Cormode et al.   RADIOLOGY

Porcine models of coronary atherosclerosis and vulnerable plaque for imaging and interventional research

(2010) Juan Granada et al.   EuroIntervention

Statin Adverse Effects

(2009) Beatrice A Golomb et al.   American Journal of Cardiovascular Drugs

Chronic inflammation and asthma

(2009) Jenna R. Murdoch et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

(2009) Aly A Khan et al.   NATURE BIOTECHNOLOGY

Targeting atherosclerosis by using modular, multifunctional micelles

(2009) D. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collagens in the progression and complications of atherosclerosis

(2009) Eser Adiguzel et al.   VASCULAR MEDICINE

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

(2008) Christophe Combadière et al.   CIRCULATION

A new atherosclerotic lesion probe based on hydrophobically modified chitosan nanoparticles functionalized by the atherosclerotic plaque targeted peptides

(2008) Kyeongsoon Park et al.   JOURNAL OF CONTROLLED RELEASE

Imaging of atherosclerotic cardiovascular disease

(2008) Javier Sanz et al.   NATURE

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prospectively Gated Transverse Coronary CT Angiography versus Retrospectively Gated Helical Technique: Improved Image Quality and Reduced Radiation Dose

(2008) James P. Earls et al.   RADIOLOGY

An ApoA-I Mimetic Peptide High-Density-Lipoprotein-Based MRI Contrast Agent for Atherosclerotic Plaque Composition Detection

(2008) David P. Cormode et al.   Small

Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis

(2007) Matthias Nahrendorf et al.   CIRCULATION