Stimuli-Responsive Plasmonic Assemblies and Their Biomedical Applications

Among the diverse development of stimuli-responsive assemblies, plasmonic nanoparticle (NP) assemblies functionalized with responsive molecules are of a major interest. In this review, we outline a comprehensive and up-to-date overview of recently reported studies on in vitro and in vivo assembly/disassembly and biomedical applications of plasmonic NPs, wherein stimuli such as enzymes, light, pH, redox potential, temperature, metal ions, magnetic or electric field, and/or multi-stimuli were involved. Stimuli-responsive assemblies have been applied in various biomedical fields including biosensors, surfaced-enhanced Raman scattering (SERS), photoacoustic (PA) imaging, multimodal imaging, photo-activated therapy, enhanced X-ray therapy, drug release, stimuli-responsive aggregation-induced cancer therapy, and so on. The perspectives on the use of stimuli-responsive plasmonic assemblies are discussed by addressing future scientific challenges involving assembly/disassembly strategies and applications. Published by Elsevier Ltd.

Automated summary

This review provides an overview of the use of plasmonic nanoparticle assemblies functionalized with responsive molecules in biomedical applications and discusses future challenges regarding assembly/disassembly strategies and applications.