Biological and pathological activities of interleukin-22

Interleukin (IL)-22 receptor 1 is over-expressed in primary Sjogren's syndrome and Sjögren-associated non-Hodgkin lymphomas and is regulated by IL-18

(2015) F. Ciccia et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C

(2015) Li-Yuan Wu et al.   CLINICAL IMMUNOLOGY

Interleukin-17 and interleukin-22 promote tumor progression in human nonmelanoma skin cancer

(2015) Lavinia Nardinocchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection

(2015) Melba Muñoz et al.   IMMUNITY

The 3 major types of innate and adaptive cell-mediated effector immunity

(2015) Francesco Annunziato et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis

(2015) Shunya Mashiko et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

(2015) Pedro P Hernández et al.   NATURE IMMUNOLOGY

Addressing the challenges of pancreatic cancer: Future directions for improving outcomes

(2015) Manuel Hidalgo et al.   PANCREATOLOGY

PLZF expression maps the early stages of ILC1 lineage development

(2015) Michael G. Constantinides et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines

(2015) Dong-Hong Lu   WORLD JOURNAL OF GASTROENTEROLOGY

Th22 cell accumulation is associated with colorectal cancer development

(2015) Yong-Hong Huang   WORLD JOURNAL OF GASTROENTEROLOGY

NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors

(2015) Wei Xu et al.   Cell Reports

Th22 cells increase in poor prognosis multiple myeloma and promote tumor cell growth and survival

(2015) Giulia Di Lullo et al.   OncoImmunology

Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signaling

(2015) Danfeng Sun et al.   OncoImmunology

IL22/IL-22R Pathway Induces Cell Survival in Human Glioblastoma Cells

(2015) Hussein Akil et al.   PLoS One

Human innate lymphoid cells

(2014) M. D. Hazenberg et al.   BLOOD

Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation

(2014) K. Kim et al.   CARCINOGENESIS

The role of the IL-22/IL-22R1 axis in cancer

(2014) Chrissie Lim et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Genetic Polymorphisms and Plasma Levels of Interleukin-22 Contribute to the Development of Nonsmall Cell Lung Cancer

(2014) Fei Liu et al.   DNA AND CELL BIOLOGY

The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation

(2014) H Laaksonen et al.   GENES AND IMMUNITY

IL-22+CD4+ T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L

(2014) Ilona Kryczek et al.   IMMUNITY

Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection

(2014) Xiaohuan Guo et al.   IMMUNITY

Cross-talk Between RORγt+ Innate Lymphoid Cells and Intestinal Macrophages Induces Mucosal IL-22 Production in Crohnʼs Disease

(2014) Shinta Mizuno et al.   INFLAMMATORY BOWEL DISEASES

Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma

(2014) Dong Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

Nfil3 is required for the development of all innate lymphoid cell subsets

(2014) Cyril Seillet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CX3CR1+mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22

(2014) Randy S. Longman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens

(2014) Theresa L. Geiger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conventional NK Cells Can Produce IL-22 and Promote Host Defense in Klebsiella pneumoniae Pneumonia

(2014) X. Xu et al.   JOURNAL OF IMMUNOLOGY

Activation of Type 3 Innate Lymphoid Cells and Interleukin 22 Secretion in the Lungs During Streptococcus pneumoniae Infection

(2014) Laurye Van Maele et al.   JOURNAL OF INFECTIOUS DISEASES

Increased Urinary Interleukin 22 Binding Protein Levels Correlate with Lupus Nephritis Activity

(2014) X. Yang et al.   JOURNAL OF RHEUMATOLOGY

Toll-Like Receptor 4-Induced IL-22 Accelerates Kidney Regeneration

(2014) O. P. Kulkarni et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Increased Intratumoral Interleukin 22 Levels and Frequencies of Interleukin 22–Producing CD4+ T Cells Correlate With Pancreatic Cancer Progression

(2014) Xuejun Xu et al.   PANCREAS

Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18

(2014) B. Zhang et al.   SCIENCE

Association of interleukin 22 polymorphisms with gastric cancer risk

(2014) Shan-yu Qin et al.   TUMOR BIOLOGY

The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor

(2014) Xiaofei Yu et al.   eLife

Recognition Strategies of Group 3 Innate Lymphoid Cells

(2014) Monica Killig et al.   Frontiers in Immunology

IL-22 Is Essential for Lung Epithelial Repair following Influenza Infection

(2013) Derek A. Pociask et al.   AMERICAN JOURNAL OF PATHOLOGY

High Expression of Interleukin-22 and Its Receptor Predicts Poor Prognosis in Pancreatic Ductal Adenocarcinoma

(2013) Zhang Wen et al.   ANNALS OF SURGICAL ONCOLOGY

Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells

(2013) Tatsuro Murano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-22 is related to development of human colon cancer by activation of STAT3

(2013) Runqiu Jiang et al.   BMC CANCER

IL-22 modulates IL-17A production and controls inflammation and tissue damage in experimental dengue infection

(2013) Rodrigo Guabiraba et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-22 serum levels are a negative prognostic indicator in patients with hepatocellular carcinoma

(2013) Oliver Waidmann et al.   HEPATOLOGY

Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment

(2013) Juanjuan Zhao et al.   HEPATOLOGY

SnapShot: Innate Lymphoid Cells

(2013) Gregory F. Sonnenberg et al.   IMMUNITY

IL-22, not simply a Th17 cytokine

(2013) Sascha Rutz et al.   IMMUNOLOGICAL REVIEWS

Candida albicans Airway Exposure Primes the Lung Innate Immune Response against Pseudomonas aeruginosa Infection through Innate Lymphoid Cell Recruitment and Interleukin-22-Associated Mucosal Response

(2013) Jean Baptiste Mear et al.   INFECTION AND IMMUNITY

Autonomous cure of damaged human intestinal epithelial cells by TLR2 and TLR4-dependent production of IL-22 in response to Spirulina polysaccharides

(2013) Akira Tominaga et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

(2013) Stefanie Kirchberger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation

(2013) Lisa A. Mielke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatoprotective and anti-fibrotic functions of interleukin-22: Therapeutic potential for the treatment of alcoholic liver disease

(2013) Xiaoni Kong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Intestinal Lin-c-Kit+NKp46-CD4- Population Strongly Produces IL-22 upon IL-1  Stimulation

(2013) Y. Lee et al.   JOURNAL OF IMMUNOLOGY

Interleukin 22 Inhibits Intracellular Growth of Mycobacterium tuberculosis by Enhancing Calgranulin A Expression

(2013) Rohan Dhiman et al.   JOURNAL OF INFECTIOUS DISEASES

Interleukin-22 Inhibits Bleomycin-Induced Pulmonary Fibrosis

(2013) Minrui Liang et al.   MEDIATORS OF INFLAMMATION

Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

(2013) J CJ Martin et al.   Mucosal Immunology

IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism

(2013) A Eken et al.   Mucosal Immunology

Therapeutic opportunities of the IL-22–IL-22R1 system

(2013) Robert Sabat et al.   NATURE REVIEWS DRUG DISCOVERY

IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

(2013) C. L. Zindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aryl hydrocarbon receptor and colitis

(2013) Ivan Monteleone et al.   Seminars in Immunopathology

Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis

(2013) Lian-Zhen Yu   WORLD JOURNAL OF GASTROENTEROLOGY

Th17 and Th22 cells in psoriatic arthritis and psoriasis

(2013) Helen Benham et al.   ARTHRITIS RESEARCH & THERAPY

Protective and Pathological Properties of IL-22 in Liver Disease

(2012) Melissa A. Cobleigh et al.   AMERICAN JOURNAL OF PATHOLOGY

Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function

(2012) Hergen Spits et al.   Annual Review of Immunology

Increased intratumoral IL-22-producing CD4+ T cells and Th22 cells correlate with gastric cancer progression and predict poor patient survival

(2012) Yuan Zhuang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Interleukin 22-producing CD4+ T cells in malignant pleural effusion

(2012) Zhi-Jian Ye et al.   CANCER LETTERS

Pro-tumour activity of interleukin-22 in HPAFII human pancreatic cancer cells

(2012) L. M. Curd et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade

(2012) Anupam Mitra et al.   CYTOKINE

Aryl Hydrocarbon Receptor Regulates Pancreatic IL-22 Production and Protects Mice From Acute Pancreatitis

(2012) Jing Xue et al.   GASTROENTEROLOGY

Interleukin-22 Promotes Proliferation of Liver Stem/Progenitor Cells in Mice and Patients With Chronic Hepatitis B Virus Infection

(2012) Dechun Feng et al.   GASTROENTEROLOGY

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

(2012) Alan M. Hanash et al.   IMMUNITY

Interleukin-22 Ameliorates Cerulein-Induced Pancreatitis in Mice by Inhibiting the Autophagic Pathway

(2012) Dechun Feng et al.   International Journal of Biological Sciences

Interleukin-22 Is Produced by Invariant Natural Killer T Lymphocytes during Influenza A Virus Infection

(2012) Christophe Paget et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Circulating Th22 and Th17 Cells are Associated with Tumor Progression and Patient Survival in Human Gastric Cancer

(2012) Tao Liu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin

(2012) Heather M. McGee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Participation of Gab1 and Gab2 in IL-22-mediated keratinocyte proliferation, migration, and differentiation

(2012) Xiaofang Zhu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection

(2012) P Kumar et al.   Mucosal Immunology

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Interleukin-22 Drives Endogenous Thymic Regeneration in Mice

(2012) J. A. Dudakov et al.   SCIENCE

A Molecular Link Between Interleukin 22 and Intestinal Mucosal Wound Healing

(2012) Xiaoyan Sun et al.   Advances in Wound Care

B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis

(2011) Mingxia Zhang et al.   CELLULAR IMMUNOLOGY

IL-22, but Not IL-17, Dominant Environment in Cutaneous T-cell Lymphoma

(2011) T. Miyagaki et al.   CLINICAL CANCER RESEARCH

A Proinflammatory Role for Interleukin-22 in the Immune Response to Hepatitis B Virus

(2011) Ye Zhang et al.   GASTROENTEROLOGY

Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3

(2011) Runqiu Jiang et al.   HEPATOLOGY

In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression

(2011) Ogyi Park et al.   HEPATOLOGY

Increased serum human β-defensin-2 levels in atopic dermatitis: Relationship to IL-22 and oncostatin M

(2011) Naoko Kanda et al.   IMMUNOBIOLOGY

Interleukin-21 induces the differentiation of human Tc22 cells via phosphorylation of signal transducers and activators of transcription

(2011) Yun Liu et al.   IMMUNOLOGY

IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1β by keratinocytes via the ROS-NLRP3-caspase-1 pathway

(2011) Kyung-Ah Cho et al.   INTERNATIONAL IMMUNOLOGY

Epidermal CCR6 + γδ T Cells Are Major Producers of IL-22 and IL-17 in a Murine Model of Psoriasiform Dermatitis

(2011) Tomotaka Mabuchi et al.   JOURNAL OF IMMUNOLOGY

Immunomodulation and Regeneration of Islet Beta Cells by Cytokines in Autoimmune Type 1 Diabetes

(2011) Bhagirath Singh et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Th22 in inflammatory and autoimmune disease: prospects for therapeutic intervention

(2011) Ning Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

In Vivo Dioxin Favors Interleukin-22 Production by Human CD4+ T Cells in an Aryl Hydrocarbon Receptor (AhR)-Dependent Manner

(2011) Nicolò Costantino Brembilla et al.   PLoS One

Correction: Lactation Defect with Impaired Secretory Activation in AEBP1-Null Mice

(2011) Lei Zhang et al.   PLoS One

Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis

(2011) Kerryn Matthews et al.   TUBERCULOSIS

Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells

(2010) Jean-Marie Ramirez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3

(2010) Sung Hwan Ki et al.   HEPATOLOGY

γδ T cells protect against lung fibrosis via IL-22

(2010) Philip L. Simonian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-22 Induces an Acute-Phase Response

(2010) S. C. Liang et al.   JOURNAL OF IMMUNOLOGY

TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3negCD127+ Immune Cells in Spleen and Mucosa

(2010) L. Van Maele et al.   JOURNAL OF IMMUNOLOGY

Interleukin-22 (IL-22) Production by Pulmonary Natural Killer Cells and the Potential Role of IL-22 during Primary Influenza Virus Infection

(2010) H. Guo et al.   JOURNAL OF VIROLOGY

The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

(2010) Hergen Spits et al.   NATURE IMMUNOLOGY

IL-22 is involved in liver regeneration after hepatectomy

(2009) Xiaodan Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

TLR2-activated human langerhans cells promote Th17 polarization via IL-1β, TGF-β and IL-23

(2009) Ehsan Aliahmadi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: A novel immunological cascade with potential relevance in psoriasis

(2009) Kerstin Wolk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22

(2009) Patricia Ribeiro de Moura et al.   FEBS LETTERS

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Th17 cytokines and mucosal immunity

(2009) Patricia J. Dubin et al.   IMMUNOLOGICAL REVIEWS

IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells

(2009) Kristine E. Nograles et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-22 Produced by Human NK Cells Inhibits Growth of Mycobacterium tuberculosis by Enhancing Phagolysosomal Fusion

(2009) R. Dhiman et al.   JOURNAL OF IMMUNOLOGY

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not

(2009) Kerstin Wolk et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

Interleukin 22 Receptor 1 Expression in Pancreas Islets

(2009) Makoto Shioya et al.   PANCREAS

Antiapoptotic Activity of Autocrine Interleukin-22 and Therapeutic Effects of Interleukin-22-Small Interfering RNA on Human Lung Cancer Xenografts

(2008) W. Zhang et al.   CLINICAL CANCER RESEARCH

Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism

(2008) Lucas Bleicher et al.   FEBS LETTERS

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29

(2008) Scott Commins et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Serine Protease Marapsin Is Expressed in Stratified Squamous Epithelia and Is Up-regulated in the Hyperproliferative Epidermis of Psoriasis and Regenerating Wounds

(2008) Wei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

(2008) Hiroaki Takatori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-22R, IL-10R2, and IL-22BP Binding Sites Are Topologically Juxtaposed on Adjacent and Overlapping Surfaces of IL-22

(2008) Paul W. Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin

(2008) Carmelo Luci et al.   NATURE IMMUNOLOGY

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

(2008) Tom Cupedo et al.   NATURE IMMUNOLOGY

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

(2008) Shean J Aujla et al.   NATURE MEDICINE

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain

(2008) Brandi C. Jones et al.   STRUCTURE

Interleukin-22 Forms Dimers that are Recognized by Two Interleukin-22R1 Receptor Chains

(2007) Mario de Oliveira Neto et al.   BIOPHYSICAL JOURNAL

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

(2007) Silke Schmechel et al.   INFLAMMATORY BOWEL DISEASES