Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts

(2012) Giorgio Trinchieri   Annual Review of Immunology

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

(2012) Alan M. Hanash et al.   IMMUNITY

Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation

(2012) Olivier Boulard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

(2012) Sergei I. Grivennikov et al.   NATURE

Lymphoid microenvironments and innate lymphoid cells in the gut

(2012) Claire Pearson et al.   TRENDS IN IMMUNOLOGY

IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma

(2011) Jiankun Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

(2011) Marie Tosolini et al.   CANCER RESEARCH

Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

(2011) M. Castellarin et al.   GENOME RESEARCH

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

(2011) A. D. Kostic et al.   GENOME RESEARCH

Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3

(2011) Runqiu Jiang et al.   HEPATOLOGY

Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology

(2011) Masahito Kamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

(2011) Alessandra Geremia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Interleukin-22 genetic polymorphisms and risk of colon cancer

(2010) Cheryl L. Thompson et al.   CANCER CAUSES & CONTROL

Interleukin-22: A cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection

(2010) Ellen Witte et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut

(2010) Gregory F. Sonnenberg et al.   IMMUNITY

Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A

(2010) Gregory F. Sonnenberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

IL-12 initiates tumor rejection via lymphoid tissue–inducer cells bearing the natural cytotoxicity receptor NKp46

(2010) Maya Eisenring et al.   NATURE IMMUNOLOGY

Endogenous IL-17 contributes to reduced tumor growth and metastasis

(2009) I. Kryczek et al.   BLOOD

Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment

(2009) Marcin Kortylewski et al.   CANCER CELL

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

(2009) Natalia Martin-Orozco et al.   IMMUNITY

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protumor vs Antitumor Functions of IL-17

(2009) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

(2009) Joshua M. Uronis et al.   PLoS One

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Antiapoptotic Activity of Autocrine Interleukin-22 and Therapeutic Effects of Interleukin-22-Small Interfering RNA on Human Lung Cancer Xenografts

(2008) W. Zhang et al.   CLINICAL CANCER RESEARCH

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

(2008) Ana Izcue et al.   IMMUNITY

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE