Human innate lymphoid cells

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

(2014) Christoph S.N. Klose et al.   CELL

The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells

(2014) Ryoji Yagi et al.   IMMUNITY

The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression

(2014) Victoria Male et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow

(2014) Cécile Daussy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gata3drives development of RORγt+group 3 innate lymphoid cells

(2014) Nicolas Serafini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A committed precursor to innate lymphoid cells

(2014) Michael G. Constantinides et al.   NATURE

Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells

(2014) Giuliana Magri et al.   NATURE IMMUNOLOGY

Lineage relationships of human interleukin-22-producing CD56+ ROR t+ innate lymphoid cells and conventional natural killer cells

(2013) Y.-O. Ahn et al.   BLOOD

Increased number and frequency of group 3 innate lymphoid cells in nonlesional psoriatic skin

(2013) B. Dyring-Andersen et al.   BRITISH JOURNAL OF DERMATOLOGY

Developmental programming of natural killer and innate lymphoid cells

(2013) Christian AJ Vosshenrich et al.   CURRENT OPINION IN IMMUNOLOGY

Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection

(2013) Paula Licona-Limón et al.   IMMUNITY

Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

(2013) Ju Qiu et al.   IMMUNITY

RORγt+ Innate Lymphoid Cells Acquire a Proinflammatory Program upon Engagement of the Activating Receptor NKp44

(2013) Timor Glatzer et al.   IMMUNITY

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

(2013) Anja Fuchs et al.   IMMUNITY

Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis

(2013) Tamar Mchedlidze et al.   IMMUNITY

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

(2013) Stefanie Kirchberger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis

(2013) Maryam Salimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of Innate Lymphoid Cells in Human Skin and Blood Demonstrates Increase of NKp44+ ILC3 in Psoriasis

(2013) Federica Villanova et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

(2013) Christoph S. N. Klose et al.   NATURE

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

(2013) Matthew R. Hepworth et al.   NATURE

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells

(2013) Ben Roediger et al.   NATURE IMMUNOLOGY

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

(2013) Lucille C Rankin et al.   NATURE IMMUNOLOGY

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis

(2013) E. Hams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice

(2013) Yasutomo Imai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

(2013) C. Barnig et al.   Science Translational Medicine

Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function

(2012) Hergen Spits et al.   Annual Review of Immunology

Innate lymphoid cells in the airways

(2012) Jennifer A. Walker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma

(2012) Roel G. J. Klein Wolterink et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II

(2012) Frederike Schmitz et al.   GUT

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

(2012) Alan M. Hanash et al.   IMMUNITY

The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells

(2012) Jenny Mjösberg et al.   IMMUNITY

The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells

(2012) Thomas Hoyler et al.   IMMUNITY

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

Innate Lymphoid Cell Interactions with Microbiota: Implications for Intestinal Health and Disease

(2012) Gregory F. Sonnenberg et al.   IMMUNITY

Retinoic-Acid-Receptor-Related Orphan Nuclear Receptor Alpha Is Required for Natural Helper Cell Development and Allergic Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

(2012) Stanislav Pantelyushin et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells

(2012) Marie Cherrier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct requirements for T-bet in gut innate lymphoid cells

(2012) Giuseppe Sciumé et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection

(2012) A. Gladiator et al.   JOURNAL OF IMMUNOLOGY

IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin

(2012) Heather M. McGee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

(2012) G. F. Sonnenberg et al.   SCIENCE

Interleukin-22 Drives Endogenous Thymic Regeneration in Mice

(2012) J. A. Dudakov et al.   SCIENCE

Functional Differences between Human NKp44− and NKp44+ RORC+ Innate Lymphoid Cells

(2012) Kerim Hoorweg et al.   Frontiers in Immunology

Development of IL-22-producing NK lineage cells from umbilical cord blood hematopoietic stem cells in the absence of secondary lymphoid tissue

(2011) Q. Tang et al.   BLOOD

IL-22, but Not IL-17, Dominant Environment in Cutaneous T-cell Lymphoma

(2011) T. Miyagaki et al.   CLINICAL CANCER RESEARCH

Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3

(2011) Runqiu Jiang et al.   HEPATOLOGY

Dectin-1-Dependent Interleukin-22 Contributes to Early Innate Lung Defense against Aspergillus fumigatus

(2011) Melissa A. Gessner et al.   INFECTION AND IMMUNITY

IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

(2011) Alessandra Geremia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity

(2011) Hong-Erh Liang et al.   NATURE IMMUNOLOGY

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease

(2011) Christian Taube et al.   PLoS One

Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate Lymphocytes

(2010) Cedric Vonarbourg et al.   IMMUNITY

Regulation of Cytokine Secretion in Human CD127+ LTi-like Innate Lymphoid Cells by Toll-like Receptor 2

(2010) Natasha K. Crellin et al.   IMMUNITY

Interleukin-1β Selectively Expands and Sustains Interleukin-22+ Immature Human Natural Killer Cells in Secondary Lymphoid Tissue

(2010) Tiffany Hughes et al.   IMMUNITY

Human NKp44+IL-22+cells and LTi-like cells constitute a stable RORC+lineage distinct from conventional natural killer cells

(2010) Natasha K. Crellin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+cell subsets from Id2-dependent precursors

(2010) Naoko Satoh-Takayama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses

(2010) Steven A. Saenz et al.   NATURE

The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

(2010) Hergen Spits et al.   NATURE IMMUNOLOGY

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of human NK-22 cells with IL-7, IL-2, and IL-1  reveals intrinsic functional plasticity

(2010) M. Cella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lineage Relationship Analysis of RORγt+Innate Lymphoid Cells

(2010) Shinichiro Sawa et al.   SCIENCE

Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH17 cytokine interleukin-22

(2009) T. Hughes et al.   BLOOD

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Human natural killer cells

(2008) M. A. Caligiuri   BLOOD

The role of the novel Th17 cytokine IL-26 in intestinal inflammation

(2008) J Dambacher et al.   GUT

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin

(2008) Carmelo Luci et al.   NATURE IMMUNOLOGY

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY

Restoration of lymphoid organ integrity through the interaction of lymphoid tissue–inducer cells with stroma of the T cell zone

(2008) Elke Scandella et al.   NATURE IMMUNOLOGY

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

(2008) Tom Cupedo et al.   NATURE IMMUNOLOGY