IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APC Min/+ mice

(2012) Yinghui Li et al.   CARCINOGENESIS

Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense

(2012) Melissa A. Kinnebrew et al.   IMMUNITY

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology

(2011) Masahito Kamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Interleukin-22: A cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection

(2010) Ellen Witte et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Interleukin-18 in Intestinal Inflammation: Friend and Foe?

(2010) Britta Siegmund   IMMUNITY

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

(2010) Rosalba Salcedo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

(2009) Joshua M. Uronis et al.   PLoS One

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain

(2008) Brandi C. Jones et al.   STRUCTURE