Normalization of Neuroinflammation: A New Strategy for Treatment of Persistent Pain and Memory/Emotional Deficits in Chronic Pain

Electrophysiological characterization of ectopic spontaneous discharge in axotomized and intact fibers upon nerve transection: a role in spontaneous pain?

(2022) Carolina Roza et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Voltage-dependent CaV3.2 and CaV2.2 channels in nociceptive pathways

(2022) Lucia Hoppanova et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors

(2022) Diana Tavares-Ferreira et al.   Science Translational Medicine

Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

(2022) Nicola Veronese et al.   Nutrients

Cilostazol Ameliorates Peripheral Neuropathic Pain in Streptozotocin-Induced Type I Diabetic Rats

(2022) Kuang-I. Cheng et al.   Frontiers in Pharmacology

IL-10 alleviates radicular pain by inhibiting TNF-α/p65 dependent Nav1.7 up-regulation in DRG neurons of rats

(2022) Yangliang Huang et al.   BRAIN RESEARCH

Targeting T-type/CaV3.2 channels for chronic pain

(2021) Song Cai et al.   Translational Research

Activation of liver X receptors prevents emotional and cognitive dysfunction by suppressing microglial M1-polarization and restoring synaptic plasticity in the hippocampus of mice

(2021) Xinxin Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain

(2021) Jussi Kupari et al.   Nature Communications

Are sensory neurons exquisitely sensitive to interleukin 1β?

(2021) Patrick L. Stemkowski et al.   JOURNAL OF NEUROIMMUNOLOGY

TNF-α acutely enhances acid-sensing ion channel currents in rat dorsal root ganglion neurons via a p38 MAPK pathway

(2021) Shuang Wei et al.   Journal of Neuroinflammation

Loss of liver X receptor β in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in mice

(2021) Xin Li et al.   MOLECULAR PSYCHIATRY

The physiological function of different voltage-gated sodium channels in pain

(2021) George Goodwin et al.   NATURE REVIEWS NEUROSCIENCE

Driving effect of BDNF in the spinal dorsal horn on neuropathic pain

(2021) Zhou Wu et al.   NEUROSCIENCE LETTERS

Activation of the dorsal, but not ventral, hippocampus relieves neuropathic pain in rodents

(2021) Xuhong Wei et al.   PAIN

Magnesium for Pain Treatment in 2021? State of the Art

(2021) Véronique Morel et al.   Nutrients

C-Jun N-terminal kinase post-translational regulation of pain-related Acid-Sensing Ion Channels 1b and 3

(2021) Clément Verkest et al.   JOURNAL OF NEUROSCIENCE

French guidelines for neuropathic pain: An update and commentary

(2021) X. Moisset et al.   REVUE NEUROLOGIQUE

A double-blind placebo-controlled trial of minocycline on translocator protein distribution volume in treatment-resistant major depressive disorder

(2021) Sophia Attwells et al.   Translational Psychiatry

Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain

(2021) Anna Tyrtyshnaia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Monoclonal Antibodies for Chronic Pain Treatment: Present and Future

(2021) Eva M. Sánchez-Robles et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of TRP ion channels in migraine and headache

(2021) Luigi Francesco Iannone et al.   NEUROSCIENCE LETTERS

Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review)

(2021) Fangyan Hu et al.   Experimental and Therapeutic Medicine

Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

(2021) Minh Q Nguyen et al.   eLife

Transient Receptor Potential Channels and Botulinum Neurotoxins in Chronic Pain

(2021) Eun Jin Go et al.   Frontiers in Molecular Neuroscience

The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice

(2021) Jun Zhang et al.   Journal of Inflammation Research

TNF-Alpha Inhibitors and Rhinosinusitis—A Systematic Review and Meta-Analysis

(2020) Zalan Piski et al.   American Journal of Rhinology & Allergy

A systematic review of the role of inflammatory biomarkers in acute, subacute and chronic non-specific low back pain

(2020) Patrick Morris et al.   BMC MUSCULOSKELETAL DISORDERS

A Protective Role of Translocator Protein in Alzheimer’s Disease Brain

(2020) Marianna E. Jung   Current Alzheimer Research

Neuroinflammation in Bipolar Depression

(2020) Francesco Benedetti et al.   Frontiers in Psychiatry

Sensory neuron–derived NaV1.7 contributes to dorsal horn neuron excitability

(2020) Sascha R. A. Alles et al.   Science Advances

Magnesium: The overlooked electrolyte in blood cancers?

(2020) Jennifer Gile et al.   BLOOD REVIEWS

Normalization of magnesium deficiency attenuated mechanical allodynia, depressive-like behaviors, and memory deficits associated with cyclophosphamide-induced cystitis by inhibiting TNF-α/NF-κB signaling in female rats

(2020) Jia-Liang Chen et al.   Journal of Neuroinflammation

Tumor necrosis factor α reduces gonadotropin-releasing hormone release through increase of forkhead box protein O1 activity

(2020) Chun Shi et al.   NEUROREPORT

Hippocampal glutamatergic synapses impairment mediated novel-object recognition dysfunction in rats with neuropathic pain

(2020) Bingrui Xiong et al.   PAIN

Gliosis and Neurodegenerative Diseases: The Role of PET and MR Imaging

(2020) Carlo Cavaliere et al.   Frontiers in Cellular Neuroscience

Differential Expression of Acid – Sensing Ion Channels in Mouse Primary Afferents in Naïve and Injured Conditions

(2020) Melina Papalampropoulou-Tsiridou et al.   Frontiers in Cellular Neuroscience

The protective effect of modafinil on vincristine‐induced peripheral neuropathy in rats: A possible role for TRPA1 receptors

(2020) Fatemeh Amirkhanloo et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Comorbid Pain and Cognitive Impairment in a Nationally Representative Adult Population

(2020) Richard L. Nahin et al.   CLINICAL JOURNAL OF PAIN

Emerging importance of satellite glia in nervous system function and dysfunction

(2020) Menachem Hanani et al.   NATURE REVIEWS NEUROSCIENCE

The revised International Association for the Study of Pain definition of pain

(2020) Srinivasa N. Raja et al.   PAIN

TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity

(2020) João Paulo Brás et al.   Cell Death & Disease

Magnesium and Pain

(2020) Hyun-Jung Shin et al.   Nutrients

Baicalin prevents the up‐regulation of TRPV1 in dorsal root ganglion and attenuates chronic neuropathic pain

(2020) Zheyin Wang et al.   Veterinary Medicine and Science

Systematic review and meta-analysis of dermatological reactions in patients with inflammatory bowel disease treated with anti-tumour necrosis factor therapy

(2020) Gaurav B. Nigam et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Electroacupuncture Modulates Spinal BDNF/TrκB Signaling Pathway and Ameliorates the Sensitization of Dorsal Horn WDR Neurons in Spared Nerve Injury Rats

(2020) Meng Xue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain

(2020) Christopher R. Donnelly et al.   Neurotherapeutics

Foxo1 selectively regulates static mechanical pain by interacting with Nav1.7

(2020) Xiao-Long Zhang et al.   PAIN

Etifoxine is non-inferior than clonazepam for reduction of anxiety symptoms in the treatment of anxiety disorders: a randomized, double blind, non-inferiority trial

(2020) Benjamín Vicente et al.   PSYCHOPHARMACOLOGY

Microglia in depression: current perspectives

(2020) Xiaoning Jia et al.   Science China-Life Sciences

K+ Channels in Primary Afferents and Their Role in Nerve Injury-Induced Pain

(2020) Peter A. Smith   Frontiers in Cellular Neuroscience

Chronic Oral Administration of Magnesium-L-Threonate Prevents Oxaliplatin-Induced Memory and Emotional Deficits by Normalization of TNF-α/NF-κB Signaling in Rats

(2020) Xin Zhou et al.   Neuroscience Bulletin

Use of TNF Inhibitors in Rheumatoid Arthritis and Implications for the Periodontal Status: For the Benefit of Both?

(2020) Fatima Zamri et al.   Frontiers in Immunology

Deletion of Acid-Sensing Ion Channel 3 Relieves the Late Phase of Neuropathic Pain by Preventing Neuron Degeneration and Promoting Neuron Repair

(2020) Chia-Chi Kung et al.   Cells

Liver X Receptor α in Sciatic Nerve Exerts an Alleviating Effect on Neuropathic Pain Behaviors Induced by Crush Injury

(2020) Zuchao Mao et al.   NEUROCHEMICAL RESEARCH

Emotional and cognitive impairments in the peripheral nerve chronic constriction injury model (CCI) of neuropathic pain: A systematic review

(2020) Diana Fonseca-Rodrigues et al.   BEHAVIOURAL BRAIN RESEARCH

Differential regulation of GSK-3β in spinal dorsal horn and in hippocampus mediated by IL-1β contributes to pain hypersensitivity and memory deficits following peripheral nerve injury

(2019) Chun-Lin Mai et al.   Molecular Pain

Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In Vivo

(2019) Robert H. Goldstein et al.   NEURON

Neuro-immune crosstalk and allergic inflammation

(2019) Hiroki Kabata et al.   JOURNAL OF CLINICAL INVESTIGATION

Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics

(2019) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Upregulation of TRPV1 in spinal dorsal root ganglion by activating NGF‐TrkA pathway contributes to pelvic organ cross‐sensitisation in rats with experimental autoimmune prostatitis

(2019) Jie Zhang et al.   ANDROLOGIA

Na V 1.6 regulates excitability of mechanosensitive sensory neurons

(2019) Mathilde R. Israel et al.   JOURNAL OF PHYSIOLOGY-LONDON

[Express] Roles of TNF-α and IL-6 in regulating bone cancer pain via TRPA1 signal pathway and beneficial effects of inhibition of neuro-inflammation and TRPA1

(2019) Ding Zhao et al.   Molecular Pain

Therapeutic options for targeting inflammatory osteoarthritis pain

(2019) Philip G. Conaghan et al.   Nature Reviews Rheumatology

Upregulation of tumor necrosis factor-alpha in the anterior cingulate cortex contributes to neuropathic pain and pain-associated aversion

(2019) Pei-Wen Yao et al.   NEUROBIOLOGY OF DISEASE

Longitudinal TSPO-PET imaging of peripheral and central myeloid cells in a mouse model of complex regional pain syndrome

(2019) Haley C. Cropper et al.   PAIN

The Role of Voltage-Gated Sodium Channels in Pain Signaling

(2019) David L. Bennett et al.   PHYSIOLOGICAL REVIEWS

Upregulation of interleukin-6 on Cav3.2 T-type calcium channels in dorsal root ganglion neurons contributes to neuropathic pain in rats with spinal nerve ligation

(2019) Qingying Liu et al.   EXPERIMENTAL NEUROLOGY

Long-term actions of interleukin-1β on K+, Na+ and Ca2+ channel currents in small, IB4-positive dorsal root ganglion neurons; possible relevance to the etiology of neuropathic pain

(2019) Myung-chul Noh et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

(2019) Li-Jun Zhou et al.   Cell Reports

Activation of liver x receptors prevents the spinal LTP induced by skin/muscle retraction in the thigh via SIRT1/NF-Κb pathway

(2019) Xiongxiong Zhong et al.   NEUROCHEMISTRY INTERNATIONAL

Peripheral Nerve Injury Triggers Neuroinflammation in the Medial Prefrontal Cortex and Ventral Hippocampus in a Subgroup of Rats with Coincident Affective Behavioural Changes

(2019) Nathan T. Fiore et al.   NEUROSCIENCE

Withdrawal from an opioid induces a transferable memory trace in the cerebrospinal fluid

(2019) Ruth Drdla-Schutting et al.   PAIN

Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Na v 1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects

(2019) Pieter Siebenga et al.   CTS-Clinical and Translational Science

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Dietary Magnesium and Chronic Disease

(2018) Forrest H. Nielsen   ADVANCES IN CHRONIC KIDNEY DISEASE

Upregulation of N-type calcium channels in the soma of uninjured dorsal root ganglion neurons contributes to neuropathic pain by increasing neuronal excitability following peripheral nerve injury

(2018) Jie Yang et al.   BRAIN BEHAVIOR AND IMMUNITY

Activity-dependent functions of non-electrical glial cells

(2018) Daisuke Kato et al.   JOURNAL OF BIOCHEMISTRY

Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction

(2018) Yue Liu et al.   MEDIATORS OF INFLAMMATION

Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy

(2018) M. Ernberg et al.   MEDIATORS OF INFLAMMATION

A SNAP-25 cleaving chimera of botulinum neurotoxin /A and /E prevents TNFα−induced elevation of the activities of native TRP channels on early postnatal rat dorsal root ganglion neurons

(2018) Marc Nugent et al.   NEUROPHARMACOLOGY

Calpain-2 Regulates TNF-α Expression Associated with Neuropathic Pain Following Motor Nerve Injury

(2018) Shao-Xia Chen et al.   NEUROSCIENCE

Upregulation of Ca v 3.2 T-type calcium channels in adjacent intact L4 dorsal root ganglion neurons in neuropathic pain rats with L5 spinal nerve ligation

(2018) Qing-Ying Liu et al.   NEUROSCIENCE RESEARCH

Neuroinflammation of the spinal cord and nerve roots in chronic radicular pain patients

(2018) Daniel S. Albrecht et al.   PAIN

Efficacy of the Nav1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy

(2018) Aoibhinn McDonnell et al.   PAIN

Interleukin 1β inhibition contributes to the antinociceptive effects of voluntary exercise on ischemia/reperfusion-induced hypersensitivity

(2018) Jessica L. Ross et al.   PAIN

Morphological and Physiological Plasticity of Spinal Lamina II GABA Neurons Is Induced by Sciatic Nerve Chronic Constriction Injury in Mice

(2018) Hongmei Zhang et al.   Frontiers in Cellular Neuroscience

Sensitization of TRPV1 receptors by TNF‑α orchestrates the development of vincristine‑induced pain

(2018) Ying Wang et al.   Oncology Letters

CCR2-dependent monocytes/macrophages exacerbate acute brain injury but promote functional recovery after ischemic stroke in mice

(2018) Weirong Fang et al.   Theranostics

Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats

(2018) Xiyuan Ba et al.   BIOMEDICINE & PHARMACOTHERAPY

Evidence for lack of direct causality between pain and affective disturbances in a rat peripheral neuropathy model

(2018) Marco R. Guimarães et al.   GENES BRAIN AND BEHAVIOR

Chronic pain as a symptom or a disease

(2018) Rolf-Detlef Treede et al.   PAIN

Magnesium: Are We Consuming Enough?

(2018) Mohammed Razzaque   Nutrients

Macrophage biology in the peripheral nervous system after injury

(2018) Richard E. Zigmond et al.   PROGRESS IN NEUROBIOLOGY

Unbalanced plasma TNF-α and IL-12/IL-10 profile in women with migraine is associated with psychological and physiological outcomes

(2017) Arão Belitardo Oliveira et al.   JOURNAL OF NEUROIMMUNOLOGY

DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain

(2017) Yan Li et al.   JOURNAL OF NEUROSCIENCE

A Critical Role for Dopamine D5 Receptors in Pain Chronicity in Male Mice

(2017) Salim Megat et al.   JOURNAL OF NEUROSCIENCE

Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial

(2017) Joanna M Zakrzewska et al.   LANCET NEUROLOGY

Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior

(2017) M. Leo et al.   MEDIATORS OF INFLAMMATION

Alzheimer's disease: Innate immunity gone awry?

(2017) Theodore B. VanItallie   METABOLISM-CLINICAL AND EXPERIMENTAL

Association Between Persistent Pain and Memory Decline and Dementia in a Longitudinal Cohort of Elders

(2017) Elizabeth L. Whitlock et al.   JAMA Internal Medicine

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Microglial dysfunction connects depression and Alzheimer’s disease

(2016) Luís Eduardo Santos et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting Tumor Necrosis Factor Alpha for Alzheimer’s Disease

(2016) Boris Decourt et al.   Current Alzheimer Research

Risk of infections using anti-TNF agents in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: a systematic review and meta-analysis

(2016) Silvia Minozzi et al.   Expert Opinion On Drug Safety

Muscle IL1  Drives Ischemic Myalgia via ASIC3-Mediated Sensory Neuron Sensitization

(2016) J. L. Ross et al.   JOURNAL OF NEUROSCIENCE

TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury

(2016) Yong Liu et al.   JOURNAL OF NEUROSCIENCE

Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

(2016) Wen-Shan Gui et al.   Molecular Pain

Translational neuropathic pain research: A clinical perspective

(2016) D. Bouhassira et al.   NEUROSCIENCE

Do we need a third mechanistic descriptor for chronic pain states?

(2016) Eva Kosek et al.   PAIN

Spinal translocator protein alleviates chronic neuropathic pain behavior and modulates spinal astrocyte–neuronal function in rats with L5 spinal nerve ligation model

(2016) Xiaoming Liu et al.   PAIN

Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain

(2016) Sylvie Diochot et al.   PAIN

Gliogenic LTP spreads widely in nociceptive pathways

(2016) M. T. Kronschlager et al.   SCIENCE

Neurological Disease as a Failure of Brain–Immune Crosstalk: The Multiple Faces of Neuroinflammation

(2016) Michal Schwartz et al.   TRENDS IN IMMUNOLOGY

Glial Activation, A Common Mechanism Underlying Spinal Synaptic Plasticity?

(2016) Li-Jun Zhou et al.   Neuroscience Bulletin

TNF-α–Induced p38MAPK Activation Regulates TRPA1 and TRPV4 Activity in Odontoblast-Like Cells

(2015) Ikhlas El Karim et al.   AMERICAN JOURNAL OF PATHOLOGY

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

(2015) Chang-Lin Li et al.   CELL RESEARCH

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

(2015) Mythily Srinivasan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Effect of Interactive Neurostimulation Therapy on Inflammatory Response in Patients With Chronic and Recurrent Mechanical Neck Pain

(2015) Julita A. Teodorczyk-Injeyan et al.   JOURNAL OF MANIPULATIVE AND PHYSIOLOGICAL THERAPEUTICS

Spinal Dopaminergic Projections Control the Transition to Pathological Pain Plasticity via a D1/D5-Mediated Mechanism

(2015) J.-Y. V. Kim et al.   JOURNAL OF NEUROSCIENCE

Increased excitability of medium-sized dorsal root ganglion neurons by prolonged interleukin-1β exposure is K+channel dependent and reversible

(2015) Patrick L. Stemkowski et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

(2015) Nanna B Finnerup et al.   LANCET NEUROLOGY

The importance of TRPV1-sensitisation factors for the development of neuropathic pain

(2015) Natalia Malek et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Unknown

(2015) Andrew Tan et al.   MOLECULAR MEDICINE

NaV1.9: a sodium channel linked to human pain

(2015) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

Thalidomide reduces mechanical hyperalgesia and depressive-like behavior induced by peripheral nerve crush in mice

(2015) F.P. Nascimento et al.   NEUROSCIENCE

A classification of chronic pain for ICD-11

(2015) Rolf-Detlef Treede et al.   PAIN

A Systematic Review of the Prevalence and Measurement of Chronic Pain in Asian Adults

(2015) Lily R. Mohamed Zaki et al.   Pain Management Nursing

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Up-Regulation of NaV1.7 Sodium Channels Expression by Tumor Necrosis Factor-α in Cultured Bovine Adrenal Chromaffin Cells and Rat Dorsal Root Ganglion Neurons

(2014) Ryuji Tamura et al.   ANESTHESIA AND ANALGESIA

Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathy

(2014) Jianying Huang et al.   BRAIN

TNF-α-mediated JNK activation in the dorsal root ganglion neurons contributes to Bortezomib-induced peripheral neuropathy

(2014) Jie Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

The anxiodepressive comorbidity in chronic pain

(2014) Ipek Yalcin et al.   Current Opinion in Anesthesiology

Long-term Potentiation at Spinal C-fiber Synapses: A Target for Pathological Pain

(2014) Xian-Guo Liu et al.   CURRENT PHARMACEUTICAL DESIGN

Activation of TLR-4 to produce tumour necrosis factor-α in neuropathic pain caused by paclitaxel

(2014) Z. Wu et al.   EUROPEAN JOURNAL OF PAIN

Over-expression of P2X7 receptors in spinal glial cells contributes to the development of chronic postsurgical pain induced by skin/muscle incision and retraction (SMIR) in rats

(2014) Yan-Lu Ying et al.   EXPERIMENTAL NEUROLOGY

Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline

(2014) Deheng Wang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Activation of Dopaminergic D2/D3 Receptors Modulates Dorsoventral Connectivity in the Hippocampus and Reverses the Impairment of Working Memory after Nerve Injury

(2014) H. Cardoso-Cruz et al.   JOURNAL OF NEUROSCIENCE

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

The role of TNF-alpha/NF-kappa B pathway on the up-regulation of voltage-gated sodium channel Nav1.7 in DRG neurons of rats with diabetic neuropathy

(2014) Yangliang Huang et al.   NEUROCHEMISTRY INTERNATIONAL

Mechanisms and pharmacology of diabetic neuropathy – experimental and clinical studies

(2014) Magdalena Zychowska et al.   Pharmacological Reports

Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium

(2014) Weiyi Gong et al.   ARTHRITIS RESEARCH & THERAPY

Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms

(2014) Michael S. Minett et al.   Cell Reports

Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain

(2013) Xiang Yang Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Intrathecal Ultra-Low Dose Naloxone Enhances the Antihyperalgesic Effects of Morphine and Attenuates Tumor Necrosis Factor-α and Tumor Necrosis Factor-α Receptor 1 Expression in the Dorsal Horn of Rats with Partial Sciatic Nerve Transection

(2013) Chih-Ping Yang et al.   ANESTHESIA AND ANALGESIA

Neuroinflammation and the generation of neuropathic pain

(2013) A Ellis et al.   BRITISH JOURNAL OF ANAESTHESIA

Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons

(2013) Kai-Feng Shen et al.   EXPERIMENTAL NEUROLOGY

Interleukin-1β orchestrates underlying inflammatory responses in microglia via Krüppel-like factor 4

(2013) Deepak K. Kaushik et al.   JOURNAL OF NEUROCHEMISTRY

The G1662S NaV1.8 mutation in small fibre neuropathy: impaired inactivation underlying DRG neuron hyperexcitability

(2013) C. Han et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The Upregulation of Translocator Protein (18 kDa) Promotes Recovery from Neuropathic Pain in Rats

(2013) X.-H. Wei et al.   JOURNAL OF NEUROSCIENCE

Impaired Spatial Memory Performance in a Rat Model of Neuropathic Pain Is Associated with Reduced Hippocampus-Prefrontal Cortex Connectivity

(2013) H. Cardoso-Cruz et al.   JOURNAL OF NEUROSCIENCE

Induction of Thermal Hyperalgesia and Synaptic Long-Term Potentiation in the Spinal Cord Lamina I by TNF-  and IL-1  is Mediated by Glial Cells

(2013) D. Gruber-Schoffnegger et al.   JOURNAL OF NEUROSCIENCE

Acid-sensing ion channels in pain and disease

(2013) John A. Wemmie et al.   NATURE REVIEWS NEUROSCIENCE

Effect of paclitaxel on transient receptor potential vanilloid 1 in rat dorsal root ganglion

(2013) Tomomi Hara et al.   PAIN

Peripheral inflammatory hyperalgesia depends on the COX increase in the dorsal root ganglion

(2013) Dionéia Araldi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of interleukin-1β in arthritic pain: Main involvement in thermal, but not mechanical, hyperalgesia in rat antigen-induced arthritis

(2012) Matthias Ebbinghaus et al.   ARTHRITIS AND RHEUMATISM

Peri-sciatic administration of recombinant rat IL-1β induces mechanical allodynia by activation of src-family kinases in spinal microglia in rats

(2012) Xu-Hong Wei et al.   EXPERIMENTAL NEUROLOGY

Sodium Channel Nav1.7 Is Essential for Lowering Heat Pain Threshold after Burn Injury

(2012) S. D. Shields et al.   JOURNAL OF NEUROSCIENCE

Abnormalities in Hippocampal Functioning with Persistent Pain

(2012) A. A. Mutso et al.   JOURNAL OF NEUROSCIENCE

Inhibitor Kappa B Kinase Beta Dependent Cytokine Upregulation in Nociceptive Neurons Contributes to Nociceptive Hypersensitivity After Sciatic Nerve Injury

(2012) Maike Kanngiesser et al.   JOURNAL OF PAIN

Expression of Nav1.7 in DRG Neurons Extends from Peripheral Terminals in the Skin to Central Preterminal Branches and Terminals in the Dorsal Horn

(2012) Joel A Black et al.   Molecular Pain

Virus-mediated shRNA Knockdown of Nav1.3 in Rat Dorsal Root Ganglion Attenuates Nerve Injury-induced Neuropathic Pain

(2012) Omar A Samad et al.   MOLECULAR THERAPY

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

(2012) Annette C. Dolphin   NATURE REVIEWS NEUROSCIENCE

Neurotrophin regulation of neural circuit development and function

(2012) Hyungju Park et al.   NATURE REVIEWS NEUROSCIENCE

Spinal Interleukin-10 Therapy to Treat Peripheral Neuropathic Pain

(2012) Erin D. Milligan et al.   NEUROMODULATION

Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system

(2012) Shannon D. Shields et al.   PAIN

Gain-of-function Nav1.8 mutations in painful neuropathy

(2012) C. G. Faber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

(2012) Michael S. Minett et al.   Nature Communications

Inactivation of TNF-α ameliorates diabetic neuropathy in mice

(2011) Isamu Yamakawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pain as a global public health priority

(2011) Daniel S Goldberg et al.   BMC PUBLIC HEALTH

The Neuroprotective Effect of a Specific P2X7 Receptor Antagonist Derives from its Ability to Inhibit Assembly of the NLRP3 Inflammasome in Glial Cells

(2011) Niamh Murphy et al.   BRAIN PATHOLOGY

The Protein Kinase IKK  Is a Potential Target for the Treatment of Inflammatory Hyperalgesia

(2011) C. V. Moser et al.   JOURNAL OF IMMUNOLOGY

Functional Recovery after Peripheral Nerve Injury is Dependent on the Pro-Inflammatory Cytokines IL-1  and TNF: Implications for Neuropathic Pain

(2011) S. Nadeau et al.   JOURNAL OF NEUROSCIENCE

Peripheral Nerve Injury Alters Blood-Spinal Cord Barrier Functional and Molecular Integrity through a Selective Inflammatory Pathway

(2011) S. Echeverry et al.   JOURNAL OF NEUROSCIENCE

Are Voltage-Gated Sodium Channels on the Dorsal Root Ganglion Involved in the Development of Neuropathic Pain?

(2011) Wei Wang et al.   Molecular Pain

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Peripheral Nerve Injury Leads to Working Memory Deficits and Dysfunction of the Hippocampus by Upregulation of TNF-α in Rodents

(2011) Wen-Jie Ren et al.   NEUROPSYCHOPHARMACOLOGY

Role of voltage-dependent calcium channel subtypes in spinal long-term potentiation of C-fiber-evoked field potentials

(2011) Soichiro Ohnami et al.   PAIN

Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat

(2010) Li-Jun Zhou et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of NF-kappaB prevents mechanical allodynia induced by spinal ventral root transection and suppresses the re-expression of Nav1.3 in DRG neurons in vivo and in vitro

(2010) Ying Zang et al.   BRAIN RESEARCH

TNF-α enhances the currents of voltage gated sodium channels in uninjured dorsal root ganglion neurons following motor nerve injury

(2010) Xi Chen et al.   EXPERIMENTAL NEUROLOGY

TNF  is a key mediator of the pronociceptive effects of mucosal supernatant from human ulcerative colitis on colonic DRG neurons

(2010) C. Ibeakanma et al.   GUT

Central mechanisms of pathological pain

(2010) Rohini Kuner   NATURE MEDICINE

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP

(2010) Thelma R. Cowley et al.   NEUROBIOLOGY OF AGING

Enhancement of Learning and Memory by Elevating Brain Magnesium

(2010) Inna Slutsky et al.   NEURON

TNF-α contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury

(2010) Xin-Hua He et al.   PAIN

Acid-Sensing Ion Channels (ASICs): Pharmacology and implication in pain

(2010) Emmanuel Deval et al.   PHARMACOLOGY & THERAPEUTICS

Proteomics in Neuropathic Pain Research

(2009) Ellen Niederberger et al.   ANESTHESIOLOGY

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis

(2009) Hayley Hernstadt et al.   BRAIN RESEARCH

Neural KCNQ (Kv7) channels

(2009) David A Brown et al.   BRITISH JOURNAL OF PHARMACOLOGY

Up-regulation of TNF-α in neurons of dorsal root ganglia and spinal cord during coronary artery occlusion in rats

(2009) Yan-Lan Niu et al.   CYTOKINE

Stress and IL-1β contribute to the development of depressive-like behavior following peripheral nerve injury

(2009) G J Norman et al.   MOLECULAR PSYCHIATRY

Experience-dependent structural synaptic plasticity in the mammalian brain

(2009) Anthony Holtmaat et al.   NATURE REVIEWS NEUROSCIENCE

A neurocognitive model of attention to pain: Behavioral and neuroimaging evidence

(2009) Valéry Legrain et al.   PAIN

Limited BDNF contributes to the failure of injury to skin afferents to produce a neuropathic pain condition

(2009) Li-Jun Zhou et al.   PAIN

The Prevalence and Impact of Chronic Pain with Neuropathic Pain Symptoms in the General Population

(2009) Cory Toth et al.   PAIN MEDICINE

Induction of Synaptic Long-Term Potentiation After Opioid Withdrawal

(2009) R. Drdla et al.   SCIENCE

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Descending control of nociception: Specificity, recruitment and plasticity

(2008) M.M. Heinricher et al.   BRAIN RESEARCH REVIEWS

Chemotherapy-induced peripheral neuropathy: Prevention and treatment strategies

(2008) Sherry Wolf et al.   EUROPEAN JOURNAL OF CANCER

Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain

(2008) Xiao-Xiu Qu et al.   EXPERIMENTAL NEUROLOGY

The IKK-NF-κB pathway: a source for novel molecular drug targets in pain therapy?

(2008) Ellen Niederberger et al.   FASEB JOURNAL

ATP induces long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn: The roles of P2X4receptors and p38 MAPK in microglia

(2008) Qing-Juan Gong et al.   GLIA

Inflammatory and prothrombotic biomarkers in patients with rheumatoid arthritis: Effects of tumor necrosis factor-α blockade

(2008) Francesca Ingegnoli et al.   JOURNAL OF AUTOIMMUNITY

Reverse of Age-Dependent Memory Impairment and Mitochondrial DNA Damage in Microglia by an Overexpression of Human Mitochondrial Transcription Factor A in Mice

(2008) Y. Hayashi et al.   JOURNAL OF NEUROSCIENCE

Nociceptors Are Interleukin-1  Sensors

(2008) A. M. Binshtok et al.   JOURNAL OF NEUROSCIENCE

Intact Aδ-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats

(2008) G. Ji et al.   NEUROSCIENCE

Relationships among pain, anxiety, and depression in primary care

(2007) Adrienne J. Means-Christensen et al.   DEPRESSION AND ANXIETY

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

(2007) Guilherme Neves et al.   NATURE REVIEWS NEUROSCIENCE

Characterization of a model of persistent postoperative pain evoked by skin/muscle incision and retraction (SMIR)

(2007) Sarah J.L. Flatters   PAIN