Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors

Considering sex as a biological variable will require a global shift in science culture

(2021) Rebecca M. Shansky et al.   NATURE NEUROSCIENCE

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

(2021) Kristen R. Maynard et al.   NATURE NEUROSCIENCE

Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain

(2021) Jussi Kupari et al.   Nature Communications

Spatial Transcriptomics: Molecular Maps of the Mammalian Brain

(2021) Cantin Ortiz et al.   Annual Review of Neuroscience

Human cells and networks of pain: Transforming pain target identification and therapeutic development

(2021) William Renthal et al.   NEURON

Diversity of Receptor Expression in Central and Peripheral Mouse Neurons Estimated from Single Cell RNA Sequencing

(2021) Andi Wangzhou et al.   NEUROSCIENCE

A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets

(2021) Andi Wangzhou et al.   Science Signaling

Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates

(2021) Amanda Klein et al.   eLife

Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

(2021) Minh Q Nguyen et al.   eLife

Bridging Genomics and Tissue Pathology

(2020) Nikhil Rao et al.   Genetic Engineering & Biotechnology News

The emergence of transcriptional identity in somatosensory neurons

(2020) Nikhil Sharma et al.   NATURE

Distribution of functional opioid receptors in human dorsal root ganglion neurons

(2020) Jamie K Moy et al.   PAIN

Pharmacological target-focused transcriptomic analysis of native versus cultured human and mouse dorsal root ganglia

(2020) Andi Wangzhou et al.   PAIN

Primary proprioceptive neurons from human induced pluripotent stem cells: a cell model for afferent ataxias

(2020) Chiara Dionisi et al.   Scientific Reports

Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization

(2020) Stephanie Shiers et al.   PAIN

Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury

(2020) William Renthal et al.   NEURON

Gain-of-function mutation in SCN11A causes itch and affects neurogenic inflammation and muscle function in Scn11a+/L799P mice

(2020) Matthias Ebbinghaus et al.   PLoS One

Increased resurgent sodium currents in Nav1.8 contribute to nociceptive sensory neuron hyperexcitability associated with peripheral neuropathies

(2019) Yucheng Xiao et al.   JOURNAL OF NEUROSCIENCE

Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons

(2019) Robert Y North et al.   BRAIN

The Role of Voltage-Gated Sodium Channels in Pain Signaling

(2019) David L. Bennett et al.   PHYSIOLOGICAL REVIEWS

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

RNA sequencing: the teenage years

(2019) Rory Stark et al.   NATURE REVIEWS GENETICS

Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties

(2019) Yang Zheng et al.   NEURON

Human Dorsal Root Ganglia

(2019) Rainer Viktor Haberberger et al.   Frontiers in Cellular Neuroscience

An ultrafast system for signaling mechanical pain in human skin

(2019) Saad S. Nagi et al.   Science Advances

The translatability of pain across species

(2019) Jeffrey S. Mogil   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Stereotyped transcriptomic transformation of somatosensory neurons in response to injury

(2019) Minh Q Nguyen et al.   eLife

CGRP as the target of new migraine therapies — successful translation from bench to clinic

(2018) Lars Edvinsson et al.   Nature Reviews Neurology

Comparative transcriptome profiling of the human and mouse dorsal root ganglia

(2018) Pradipta Ray et al.   PAIN

Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

(2018) Rahul Dhandapani et al.   Nature Communications

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Termination of cell-type specification gene programs by the miR-183 cluster determines the population sizes of low-threshold mechanosensitive neurons

(2018) Changgeng Peng et al.   DEVELOPMENT

A disease mutation reveals a role for NaV1.9 in acute itch

(2018) Juan Salvatierra et al.   JOURNAL OF CLINICAL INVESTIGATION

PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

(2018) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

GENCODE reference annotation for the human and mouse genomes

(2018) Adam Frankish et al.   NUCLEIC ACIDS RESEARCH

Human vs. Mouse Nociceptors – Similarities and Differences

(2017) Charlotte Rostock et al.   NEUROSCIENCE

Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors

(2017) Vincenzo Prato et al.   Cell Reports

An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish

(2017) Philia Gau et al.   PLoS Genetics

Sex differences in neuroimmunity and pain

(2016) Sarah Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures

(2016) Manouela V Valtcheva et al.   Nature Protocols

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

(2016) P. L. Stahl et al.   SCIENCE

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

The specification and wiring of mammalian cutaneous low-threshold mechanoreceptors

(2016) William Olson et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Navβ4 Regulates Fast Resurgent Sodium Currents and Excitability in Sensory Neurons

(2015) Cindy Barbosa et al.   Molecular Pain

Transcriptional regulator PRDM12 is essential for human pain perception

(2015) Ya-Chun Chen et al.   NATURE GENETICS

The phenotype of congenital insensitivity to pain due to the NaV1.9 variant p.L811P

(2014) Christopher Geoffrey Woods et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Lysophosphatidic Acid and its Receptors LPA1 and LPA3 Mediate Paclitaxel-Induced Neuropathic Pain in Mice

(2014) Hitoshi Uchida et al.   Molecular Pain

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

The gentle touch receptors of mammalian skin

(2014) A. Zimmerman et al.   SCIENCE

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

(2013) Ferda Cevikbas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Sensory Neurons of Touch

(2013) Victoria E. Abraira et al.   NEURON

Neuronal prostaglandin E2 receptor subtype EP3 mediates antinociception during inflammation

(2013) G. Natura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cells and Circuitry for Itch Responses in Mice

(2013) S. K. Mishra et al.   SCIENCE

Inhibition of Nav 4 Peptide-Mediated Resurgent Sodium Currents in Nav1.7 Channels by Carbamazepine, Riluzole, and Anandamide

(2011) J. W. Theile et al.   MOLECULAR PHARMACOLOGY

Nociceptors: the sensors of the pain pathway

(2010) Adrienne E. Dubin et al.   JOURNAL OF CLINICAL INVESTIGATION

Locally Synthesized Calcitonin Gene-Related Peptide Has a Critical Role in Peripheral Nerve Regeneration

(2009) Cory C. Toth et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Separate Peripheral Pathways for Pruritus in Man

(2008) Barbara Namer et al.   JOURNAL OF NEUROPHYSIOLOGY