Targeting T-type/CaV3.2 channels for chronic pain

A modulator of the low-voltage-activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies

(2020) Song Cai et al.   PAIN

Contribution of T-Type Calcium Channels to Spinal Cord Injury-Induced Hyperexcitability of Nociceptors

(2020) Justas Lauzadis et al.   JOURNAL OF NEUROSCIENCE

Cav3.2 overexpression in L4 dorsal root ganglion neurons after L5 spinal nerve cutting involves Egr-1, USP5 and HMGB1 in rats: An emerging signaling pathway for neuropathic pain

(2020) Shiori Tomita et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

[Express] Nerve injury elevates functional Cav3.2 channels in superficial spinal dorsal horn

(2019) Xiao-Jin Feng et al.   Molecular Pain

Inhibition of Ca v 3.2 calcium channels: A new target for colonic hypersensitivity associated with low‐grade inflammation

(2019) Elodie Picard et al.   BRITISH JOURNAL OF PHARMACOLOGY

A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy

(2019) Aisylu S. Gaifullina et al.   PAIN

SUMOylation regulates USP5-Cav3.2 calcium channel interactions

(2019) Agustin Garcia-Caballero et al.   Molecular Brain

Cdk5-dependent phosphorylation of Cav3.2 T-type channels: possible role in nerve ligation-induced neuropathic allodynia and the compound action potential in primary afferent C-fibers

(2019) Kimberly Gomez et al.   JOURNAL OF NEUROSCIENCE

Pathogenesis of paclitaxel-induced peripheral neuropathy: A current review of in vitro and in vivo findings using rodent and human model systems

(2019) Nathan P. Staff et al.   EXPERIMENTAL NEUROLOGY

Increased expression of CaV3.2 T-type calcium channels in damaged DRG neurons contributes to neuropathic pain in rats with spared nerve injury

(2018) Xue-Jing Kang et al.   Molecular Pain

Upregulation of Ca v 3.2 T-type calcium channels in adjacent intact L4 dorsal root ganglion neurons in neuropathic pain rats with L5 spinal nerve ligation

(2018) Qing-Ying Liu et al.   NEUROSCIENCE RESEARCH

CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage

(2018) Hiroki Abe et al.   SCIENCE

Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Ca v 3.2 in mice

(2018) Tomoka Ozaki et al.   TOXICOLOGY

Accumulation of Cav3.2 T-type Calcium Channels in the Uninjured Sural Nerve Contributes to Neuropathic Pain in Rats with Spared Nerve Injury

(2018) Wen Chen et al.   Frontiers in Molecular Neuroscience

Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels

(2018) Shreya S. Bellampalli et al.   PAIN

Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain

(2018) Sonja L. Joksimovic et al.   Science Signaling

Disrupting USP5/Cav3.2 interactions protects female mice from mechanical hypersensitivity during peripheral inflammation

(2018) Vinicius M. Gadotti et al.   Molecular Brain

Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3.2–USP5 interactions in the pain pathway

(2017) Patrick L Stemkowski et al.   Molecular Pain

Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy

(2017) Yan Li et al.   PAIN

Identification of Novel N-Glycosylation Sites at Noncanonical Protein Consensus Motifs

(2016) Mark S. Lowenthal et al.   JOURNAL OF PROTEOME RESEARCH

Colocalization of insulin-like growth factor-1 receptor and T type Cav3.2 channel in dorsal root ganglia in chronic inflammatory pain mouse model

(2016) Si-Fang Lin et al.   NEUROREPORT

Chronic intrathecal infusion of mibefradil, ethosuximide and nickel attenuates nerve ligation-induced pain in rats

(2015) Y.L. Chen et al.   BRITISH JOURNAL OF ANAESTHESIA

Small Organic Molecule Disruptors of Cav3.2 - USP5 Interactions Reverse Inflammatory and Neuropathic Pain

(2015) Vinicius M Gadotti et al.   Molecular Pain

Upregulation of T-Type Ca2+ Channels in Long-Term Diabetes Determines Increased Excitability of a Specific Type of Capsaicin-Insensitive DRG Neurons

(2015) Dmytro E Duzhyy et al.   Molecular Pain

Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties

(2015) Iulia Blesneac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function

(2015) Amaury François et al.   Cell Reports

Expression and Regulation of Cav3.2 T-Type Calcium Channels during Inflammatory Hyperalgesia in Mouse Dorsal Root Ganglion Neurons

(2015) Masaya Watanabe et al.   PLoS One

Hyperhomocysteinemia and Neurologic Disorders: a Review

(2014) Ramin Ansari et al.   Journal of Clinical Neurology

Z944: A first in class T-type calcium channel modulator for the treatment of pain

(2014) M Lee   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

The Deubiquitinating Enzyme USP5 Modulates Neuropathic and Inflammatory Pain by Enhancing Cav3.2 Channel Activity

(2014) Agustin García-Caballero et al.   NEURON

Cav3 T-type channels: regulators for gating, membrane expression, and cation selectivity

(2014) A. Senatore et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Functional Expression of T-Type Ca2+ Channels in Spinal Motoneurons of the Adult Turtle

(2014) Martha Canto-Bustos et al.   PLoS One

Peripheral pain is enhanced by insulin-like growth factor 1 through a G protein-mediated stimulation of T-type calcium channels

(2014) Y. Zhang et al.   Science Signaling

Specific functioning of Cav3.2 T-type calcium and TRPV1 channels under different types of STZ-diabetic neuropathy

(2013) Eugen V. Khomula et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reversal of Neuropathic Pain in Diabetes by Targeting Glycosylation of Cav3.2 T-Type Calcium Channels

(2013) P. Orestes et al.   DIABETES

Surface expression and function of Cav3.2 T-type calcium channels are controlled by asparagine-linked glycosylation

(2013) Norbert Weiss et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Modulation of low-voltage-activated T-type Ca2+ channels

(2012) Yuan Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Involvement of the endogenous hydrogen sulfide/Cav3.2 T-type Ca2+channel pathway in cystitis-related bladder pain in mice

(2012) Maho Matsunami et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transcriptional Regulation of T-type Calcium Channel CaV3.2

(2012) Karen M. J. van Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presynaptic CaV3.2 Channels Regulate Excitatory Neurotransmission in Nociceptive Dorsal Horn Neurons

(2012) M. O. Jacus et al.   JOURNAL OF NEUROSCIENCE

Upregulation of T-type Ca2+ Channels in Primary Sensory Neurons in Spinal Nerve Injury

(2012) Jing Yue et al.   SPINE

T-type voltage-gated calcium channels as targets for the development of novel pain therapies

(2011) Slobodan M Todorovic et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Cav3.2/Syntaxin-1A Signaling Complex Controls T-type Channel Activity and Low-threshold Exocytosis

(2011) Norbert Weiss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chelating luminal zinc mimics hydrogen sulfide-evoked colonic pain in mice: possible involvement of T-type calcium channels

(2011) M. Matsunami et al.   NEUROSCIENCE

T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome

(2011) F. Marger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the gating brake in the I-II loop of CaV3 T-type calcium channels

(2010) Edward Perez-Reyes   Channels

Contributions of T-type calcium channel isoforms to neuronal firing

(2010) Stuart M. Cain et al.   Channels

N-glycosylation at non-canonical Asn-X-Cys sequence of an insect recombinant cathepsin B-like counter-defense protein

(2010) Yong Hun Chi et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Selective T-Type Calcium Channel Block in Thalamic Neurons Reveals Channel Redundancy and Physiological Impact of ITwindow

(2010) F. M. Dreyfus et al.   JOURNAL OF NEUROSCIENCE

In Vitro Characterization of T-Type Calcium Channel Antagonist TTA-A2 and In Vivo Effects on Arousal in Mice

(2010) R. L. Kraus et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Upregulation of Cav3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain

(2010) Tomoko Takahashi et al.   PAIN

The Roles of T-Type Calcium Channel in the Development of Neuropathic Pain following Chronic Compression of Rat Dorsal Root Ganglia

(2010) Xian-Jie Wen et al.   PHARMACOLOGY

Selective T-Type Calcium Channel Blockade Alleviates Hyperalgesia in ob/ob Mice

(2009) J. R. Latham et al.   DIABETES

Structural Determinants of the High Affinity Extracellular Zinc Binding Site on Cav3.2 T-type Calcium Channels

(2009) Ho-Won Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo silencing of the CaV3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy

(2009) Richard B. Messinger et al.   PAIN

Upregulation of the T-Type Calcium Current in Small Rat Sensory Neurons After Chronic Constrictive Injury of the Sciatic Nerve

(2008) Miljen M. Jagodic et al.   JOURNAL OF NEUROPHYSIOLOGY

Regulation of neuronal T-type calcium channels

(2008) Mircea C. Iftinca et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Painful Diabetic Neuropathy: Epidemiology, Natural History, Early Diagnosis, and Treatment Options

(2007) Aristidis Veves et al.   PAIN MEDICINE