Role of mitochondria-associated endoplasmic reticulum membranes in insulin sensitivity, energy metabolism, and contraction of skeletal muscle

Implications of mitochondrial fusion and fission in skeletal muscle mass and health

(2022) Vanina Romanello et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

OPA1 Modulates Mitochondrial Ca2+ Uptake Through ER-Mitochondria Coupling

(2022) Benjamín Cartes-Saavedra et al.   Frontiers in Cell and Developmental Biology

Organelle transporters and inter-organelle communication as drivers of metabolic regulation and cellular homeostasis

(2022) Aakriti Jain et al.   Molecular Metabolism

Mitochondrial Dynamics, Mitophagy, and Mitochondria–Endoplasmic Reticulum Contact Sites Crosstalk Under Hypoxia

(2022) Shuying Wang et al.   Frontiers in Cell and Developmental Biology

Mitochondria Associated Membranes (MAMs): Architecture and physiopathological role

(2021) Lucia Barazzuol et al.   CELL CALCIUM

BOK controls apoptosis by Ca2+ transfer through ER-mitochondrial contact sites

(2021) Marcos A. Carpio et al.   Cell Reports

Low abundance of Mfn2 protein correlates with reduced mitochondria‐SR juxtaposition and mitochondrial cristae density in human men skeletal muscle: Examining organelle measurements from TEM images

(2021) Mauricio Castro‐Sepulveda et al.   FASEB JOURNAL

The MAMs Structure and Its Role in Cell Death

(2021) Nan Wang et al.   Cells

BAP31: Physiological functions and roles in disease

(2021) Esben M. Quistgaard   BIOCHIMIE

Dynamic control of mitochondria-associated membranes by kinases and phosphatases in health and disease

(2021) Monika Pichla et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo

(2021) Song Han et al.   JOURNAL OF CELL SCIENCE

Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans

(2021) Christopher L. Axelrod et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging

(2021) Ciarán E. Fealy et al.   TRENDS IN MOLECULAR MEDICINE

Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function

(2021) L. Grevendonk et al.   Nature Communications

Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis

(2021) Pengcheng Zhang et al.   Cells

ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1

(2021) Seong Keun Sonn et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle

(2021) Yuhei Mizunoe et al.   EXPERIMENTAL GERONTOLOGY

It takes two to tango: The essential role of ER-mitochondrial contact sites in mitochondrial dynamics

(2021) Irene M.G.M. Hemel et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

GRP75 mediates endoplasmic reticulum–mitochondria coupling during palmitate-induced pancreatic β-cell apoptosis

(2021) Shweta Tiwary et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct mechanisms involving diacylglycerol, ceramides, and inflammation underlie insulin resistance in oxidative and glycolytic muscles from high fat-fed rats

(2021) Shailee Jani et al.   Scientific Reports

Subcellular Specialization of Mitochondrial Form and Function in Skeletal Muscle Cells

(2021) T. Bradley Willingham et al.   Frontiers in Cell and Developmental Biology

Mitochondrial dysfunction, insulin resistance and potential genetic implications

(2020) Panjamaporn Sangwung et al.   ENDOCRINOLOGY

Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology

(2020) Robert G. Abrisch et al.   JOURNAL OF CELL BIOLOGY

Relative lipid oxidation associates directly with mitochondrial fusion phenotype and mitochondria-sarcoplasmic reticulum interactions in human skeletal muscle

(2020) Mauricio Castro-Sepulveda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance

(2020) Stacey N. Keenan et al.   Current Diabetes Reports

Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?

(2020) Alexis Diaz-Vegas et al.   ENDOCRINE REVIEWS

The effect of resistance training, detraining and retraining on muscle strength and power, myofibre size, satellite cells and myonuclei in older men

(2020) Sara Blocquiaux et al.   EXPERIMENTAL GERONTOLOGY

Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

(2020) Katarzyna Kolczynska et al.   Lipids in Health and Disease

New role for ceramide in hypoxia and insulin resistance

(2020) Qing-Song Xia et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Swimming Differentially Affects T2DM-Induced Skeletal Muscle ER Stress and Mitochondrial Dysfunction Related to MAM

(2020) Zhe Zhang et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults

(2020) Benjamin J Ryan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Omega-3 Polyunsaturated Fatty Acids Mitigate Palmitate-Induced Impairments in Skeletal Muscle Cell Viability and Differentiation

(2020) Bill Tachtsis et al.   Frontiers in Physiology

Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis

(2020) Cecilia Marini et al.   EJNMMI Research

Mitochondria-Associated ER Membranes – The Origin Site of Autophagy

(2020) Ming Yang et al.   Frontiers in Cell and Developmental Biology

Eukarion-134 Attenuates Endoplasmic Reticulum Stress-Induced Mitochondrial Dysfunction in Human Skeletal Muscle Cells

(2020) Anastasia Thoma et al.   Antioxidants

Mitochondria-associated ER membranes in glucose homeostasis and insulin resistance

(2020) Logan K. Townsend et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A KETOGENIC DIET COMBINED WITH EXERCISE ALTERS MITOCHONDRIAL FUNCTION IN HUMAN SKELETAL MUSCLE WHILE IMPROVING METABOLIC HEALTH

(2020) Vincent J Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PACS-2: A key regulator of mitochondria-associated membranes (MAMs)

(2020) Chenrui Li et al.   PHARMACOLOGICAL RESEARCH

The Molecular Mechanisms Underlying Mitochondria-Associated Endoplasmic Reticulum Membrane-Induced Insulin Resistance

(2020) Han Cheng et al.   Frontiers in Endocrinology

Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network

(2019) Amy E. Vincent et al.   Cell Reports

SELENON (SEPN1) protects skeletal muscle from saturated fatty acid-induced ER stress and insulin resistance

(2019) Ersilia Varone et al.   Redox Biology

BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites

(2019) Takushi Namba   Science Advances

Metabolic implications of organelle–mitochondria communication

(2019) Isabel Gordaliza‐Alaguero et al.   EMBO REPORTS

Endurance exercise decreases protein synthesis and ER-mitochondria contacts in mice skeletal muscle

(2019) Audrey Merle et al.   JOURNAL OF APPLIED PHYSIOLOGY

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

(2018) Emily Tubbs et al.   DIABETES

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

(2018) Verónica Eisner et al.   NATURE CELL BIOLOGY

Highlighting the endoplasmic reticulum-mitochondria connection: Focus on Mitofusin 2

(2018) Riccardo Filadi et al.   PHARMACOLOGICAL RESEARCH

IP3R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model

(2018) Han Xu et al.   BMC Nephrology

Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism

(2018) Alexis R. Díaz-Vegas et al.   Frontiers in Physiology

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling

(2018) Brandon M. Gassaway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics

(2018) Alice Rossi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PDK4 Augments ER-Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity

(2018) Themis Thoudam et al.   DIABETES

Subcellular connectomic analyses of energy networks in striated muscle

(2018) Christopher K. E. Bleck et al.   Nature Communications

Associations of human skeletal muscle fiber type and insulin sensitivity, blood lipids, and vascular hemodynamics in a cohort of premenopausal women

(2017) Gordon Fisher et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

The coming of age of the mitochondria–ER contact: a matter of thickness

(2016) M Giacomello et al.   CELL DEATH AND DIFFERENTIATION

MECHANISMS IN ENDOCRINOLOGY: Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes: a causal mechanism or an innocent bystander?

(2016) Charlotte Brøns et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Muscle fiber type diversification during exercise and regeneration

(2016) Rizwan Qaisar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic signaling functions of ER–mitochondria contact sites: role in metabolic diseases

(2016) Emily Tubbs et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs

(2016) David L. Prole et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial-generated ROS down regulates insulin signaling via activation of the p38MAPK stress response pathway

(2016) Rabab Al-Lahham et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

(2016) Andrew S. Moore et al.   Nature Communications

The endoplasmic reticulum: structure, function and response to cellular signaling

(2015) Dianne S. Schwarz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lipid-mediated muscle insulin resistance: different fat, different pathways?

(2015) Olesja Ritter et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mitochondrial reticulum for cellular energy distribution in muscle

(2015) Brian Glancy et al.   NATURE

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Mitochondrial Biogenesis to Treat Insulin Resistance

(2014) Monica Zamora et al.   CURRENT PHARMACEUTICAL DESIGN

Human Muscle Fiber Type–Specific Insulin Signaling: Impact of Obesity and Type 2 Diabetes

(2014) Peter H. Albers et al.   DIABETES

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Depressing Mitochondria-Reticulum Interactions Protects Cardiomyocytes From Lethal Hypoxia-Reoxygenation Injury

(2013) Melanie Paillard et al.   CIRCULATION

"Deficiency" of Mitochondria in Muscle Does Not Cause Insulin Resistance

(2013) J. O. Holloszy   DIABETES

Slow-Twitch Fiber Proportion in Skeletal Muscle Correlates With Insulin Responsiveness

(2013) Charles A. Stuart et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Musclin Inhibits Insulin Activation of Akt/Protein Kinase B in Rat Skeletal Muscle

(2013) Y Liu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Overexpression of mitofusin 2 improves translocation of glucose transporter 4 in skeletal muscle of high-fat diet-fed rats through AMP-activated protein kinase signaling

(2013) DEXIAN KONG et al.   Molecular Medicine Reports

Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

(2013) Larysa V. Yuzefovych et al.   PLoS One

No evidence for inositol 1,4,5-trisphosphate–dependent Ca2+release in isolated fibers of adult mouse skeletal muscle

(2012) Bert Blaauw et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium signaling around Mitochondria Associated Membranes (MAMs)

(2011) Simone Patergnani et al.   Cell Communication and Signaling

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Skeletal Muscle IP3R1 Receptors Amplify Physiological and Pathological Synaptic Calcium Signals

(2011) H. Zhu et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

(2011) H.-F. Jheng et al.   MOLECULAR AND CELLULAR BIOLOGY

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis

(2010) Louise Deldicque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction

(2010) Ryota Iwasawa et al.   EMBO JOURNAL

Mitochondrial fission and remodelling contributes to muscle atrophy

(2010) Vanina Romanello et al.   EMBO JOURNAL

The unfolded protein response in human skeletal muscle is not involved in the onset of glucose tolerance impairment induced by a fat-rich diet

(2010) Louise Deldicque et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model

(2010) Balindiwe Sishi et al.   EXPERIMENTAL PHYSIOLOGY

IP3-dependent, post-tetanic calcium transients induced by electrostimulation of adult skeletal muscle fibers

(2010) Mariana Casas et al.   JOURNAL OF GENERAL PHYSIOLOGY

Subsarcolemmal and intermyofibrillar mitochondria proteome differences disclose functional specializations in skeletal muscle

(2010) Rita Ferreira et al.   PROTEOMICS

SR/ER–mitochondrial local communication: Calcium and ROS

(2009) György Csordás et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Akt and 14-3-3 Control a PACS-2 Homeostatic Switch that Integrates Membrane Traffic with TRAIL-Induced Apoptosis

(2009) Joseph E. Aslan et al.   MOLECULAR CELL

Characterization and temporal development of cores in a mouse model of malignant hyperthermia

(2009) S. Boncompagni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY