New role for ceramide in hypoxia and insulin resistance

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance

(2018) Song-Yang Zhang et al.   EBioMedicine

Hypoxia Exacerbates Inflammatory Acute Lung Injury via the Toll-Like Receptor 4 Signaling Pathway

(2018) Gang Wu et al.   Frontiers in Immunology

The role of hypoxia-inducible factors in metabolic diseases

(2018) Frank J. Gonzalez et al.   Nature Reviews Endocrinology

ANT2 mediates hypoxia and inflammation in obesity

(2018) Isobel Leake   Nature Reviews Endocrinology

Tales from the crypt: new insights into intestinal stem cells

(2018) Helmuth Gehart et al.   Nature Reviews Gastroenterology & Hepatology

Determinants of hypoxia-inducible factor activity in the intestinal mucosa

(2017) Raphael R. Fagundes et al.   JOURNAL OF APPLIED PHYSIOLOGY

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

(2017) Cen Xie et al.   NATURE MEDICINE

Oxygen metabolism and barrier regulation in the intestinal mucosa

(2016) Louise E. Glover et al.   JOURNAL OF CLINICAL INVESTIGATION

CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance

(2016) Scott A. Summers et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease

(2016) Xinxia Chang et al.   Journal of Translational Medicine

Metabolic changes in type 2 diabetes are reflected in peripheral blood cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia inducible factor activity

(2015) Tineke C. T. M. van der Pouw Kraan et al.   BMC Medical Genomics

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes

(2015) Takhar Kasumov et al.   Obesity

Intestinal permeability – a new target for disease prevention and therapy

(2014) Stephan C Bischoff et al.   BMC GASTROENTEROLOGY

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

Hypoxia in the intestine or solid tumors: A beneficial or deleterious alarm signal?

(2014) Hussein Shehade et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ceramide Mediates Acute Oxygen Sensing in Vascular Tissues

(2013) Laura Moreno et al.   ANTIOXIDANTS & REDOX SIGNALING

Inflammation during obesity is not all bad: evidence from animal and human studies

(2012) Jianping Ye et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic inflammation: Connecting obesity and insulin resistance

(2012) Nassim Dali-Youcef et al.   ANNALS OF MEDICINE

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Hypoxia-inducible Factor 1α Regulates a SOCS3-STAT3-Adiponectin Signal Transduction Pathway in Adipocytes

(2012) Changtao Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of ceramides in nonalcoholic fatty liver disease

(2012) Mangesh Pagadala et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The intestinal epithelial barrier in the control of homeostasis and immunity

(2011) Maria Rescigno   TRENDS IN IMMUNOLOGY

Neutral sphingomyelinase, NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction

(2010) Giovanna Frazziano et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

Hypoxia-induced neuronal apoptosis is mediated by de novo synthesis of ceramide through activation of serine palmitoyltransferase

(2009) Mi Sun Kang et al.   CELLULAR SIGNALLING

Mechanisms of obesity and related pathologies: The macro- and microcirculation of adipose tissue

(2009) Joseph M. Rutkowski et al.   FEBS Journal

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

CELL BIOLOGY: Ceramides--Friend or Foe in Hypoxia?

(2009) C. M. Crowder   SCIENCE

The sphingolipid salvage pathway in ceramide metabolism and signaling

(2008) Kazuyuki Kitatani et al.   CELLULAR SIGNALLING

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights fromin VivoManipulation of Sphingolipid Metabolism

(2008) William L. Holland et al.   ENDOCRINE REVIEWS

Plasma Membrane-associated Sialidase as a Crucial Regulator of Transmembrane Signalling

(2008) T. Miyagi et al.   JOURNAL OF BIOCHEMISTRY

Ceramide Generated by Sphingomyelin Hydrolysis and the Salvage Pathway Is Involved in Hypoxia/Reoxygenation-induced Bax Redistribution to Mitochondria in NT-2 Cells

(2008) Junfei Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element-Binding Protein-Regulated Gene Expression and Cholesterol Synthesis in HepG2 Cells

(2008) N. Bijl et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY