Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs

Calcium and mitochondria in the regulation of cell death

(2015) Sten Orrenius et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria

(2015) Nino Natsvlishvili et al.   BMC BIOCHEMISTRY

The SR/ER-mitochondria calcium crosstalk is regulated by GSK3β during reperfusion injury

(2015) L Gomez et al.   CELL DEATH AND DIFFERENTIATION

IRBIT regulates CaMKIIα activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation

(2015) Katsuhiro Kawaai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule-Associated Protein EB3 Regulates IP 3 Receptor Clustering and Ca 2+ Signaling in Endothelial Cells

(2015) Melissa Geyer et al.   Cell Reports

IRBIT: A regulator of ion channels and ion transporters

(2014) Hideaki Ando et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Single-Molecule Tracking of Inositol Trisphosphate Receptors Reveals Different Motilities and Distributions

(2014) Ian F. Smith et al.   BIOPHYSICAL JOURNAL

A Proteome-Scale Map of the Human Interactome Network

(2014) Thomas Rolland et al.   CELL

Identifying biological pathways that underlie primordial short stature using network analysis

(2014) Dan Hanson et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Comprehensive analysis of loops at protein-protein interfaces for macrocycle design

(2014) Jason Gavenonis et al.   Nature Chemical Biology

In silico prediction of physical protein interactions and characterization of interactome orphans

(2014) Max Kotlyar et al.   NATURE METHODS

The BioGRID interaction database: 2015 update

(2014) Andrew Chatr-aryamontri et al.   NUCLEIC ACIDS RESEARCH

Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex

(2014) Gregory J. Fredericks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival

(2014) M.-J. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors

(2014) K. Hamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes

(2014) A. Arnaoutov et al.   SCIENCE

The endoplasmic reticulum and junctional membrane communication during calcium signaling

(2013) Andy K.M. Lam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner

(2013) A Bononi et al.   CELL DEATH AND DIFFERENTIATION

Depressing Mitochondria-Reticulum Interactions Protects Cardiomyocytes From Lethal Hypoxia-Reoxygenation Injury

(2013) Melanie Paillard et al.   CIRCULATION

Molecular interaction and functional coupling between type 3 inositol 1,4,5-trisphosphate receptor and BKCa channel stimulate breast cancer cell proliferation

(2013) Abdallah Mound et al.   EUROPEAN JOURNAL OF CANCER

The Bcl-2 Protein Family Member Bok Binds to the Coupling Domain of Inositol 1,4,5-Trisphosphate Receptors and Protects Them from Proteolytic Cleavage

(2013) Jacqualyn J. Schulman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases

(2013) Sandra Orchard et al.   NUCLEIC ACIDS RESEARCH

A Bead Aggregation Assay for Detection of Low-Affinity Protein-Protein Interactions Reveals Interactions between N-Terminal Domains of Inositol 1,4,5-Trisphosphate Receptors

(2013) Alap P. Chavda et al.   PLoS One

Early Insights into the Function of KIAA1199, a Markedly Overexpressed Protein in Human Colorectal Tumors

(2013) Amit Tiwari et al.   PLoS One

Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptors

(2013) P. J. Sung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions

(2013) C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the Cl- Channel ANO1 by Localized Calcium Signals in Nociceptive Sensory Neurons Requires Coupling with the IP3 Receptor

(2013) X. Jin et al.   Science Signaling

Creating Order from Chaos: Cellular Regulation by Kinase Anchoring

(2012) John D. Scott et al.   Annual Review of Pharmacology and Toxicology

Profiling of the Bcl-2/Bcl-XL-binding sites on type 1 IP3 receptor

(2012) Giovanni Monaco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Census of Human Soluble Protein Complexes

(2012) Pierre C. Havugimana et al.   CELL

Vimentin and the K-Ras-induced actin-binding protein control inositol-(1,4,5)-trisphosphate receptor redistribution during MDCK cell differentiation

(2012) Florent Dingli et al.   JOURNAL OF CELL SCIENCE

Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Expands Its Role in Regulation of RNA Polymerase I Transcription

(2012) Yuan-Chin Tsai et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural and functional conservation of key domains in InsP3 and ryanodine receptors

(2012) Min-Duk Seo et al.   NATURE

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes

(2012) Yiguo Wang et al.   NATURE

Identification and Analysis of Cation Channel Homologues in Human Pathogenic Fungi

(2012) David L. Prole et al.   PLoS One

Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes

(2012) Hiroshi Matsuzaki et al.   FEBS Open Bio

KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells

(2011) Takahiro Fujimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

InsP3receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences

(2011) Gyorgy Lur et al.   BIOCHEMICAL JOURNAL

Polycystin-1, 2, and STIM1 Interact with IP3R to Modulate ER Ca2+ Release through the PI3K/Akt Pathway

(2011) Netty G. Santoso et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN

(2011) Philipp Schläfli et al.   FEBS Journal

RNF170 Protein, an Endoplasmic Reticulum Membrane Ubiquitin Ligase, Mediates Inositol 1,4,5-Trisphosphate Receptor Ubiquitination and Degradation

(2011) Justine P. Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B

(2011) Sayaka Tanaka et al.   Journal of Physiological Sciences

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

Trisk 32 regulates IP3 receptors in rat skeletal myoblasts

(2011) Tamás Oláh et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Identification of Intracellular and Plasma Membrane Calcium Channel Homologues in Pathogenic Parasites

(2011) David L. Prole et al.   PLoS One

Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+signaling

(2011) Marioly Müller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial organization of intracellular Ca2+ signals

(2011) Vera Konieczny et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

(2010) Yulia Komarova et al.   Annual Review of Physiology

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Role of secretory granules in inositol 1,4,5-trisphosphate-dependent Ca2+ signaling: From phytoplankton to mammals

(2010) Seung Hyun Yoo   CELL CALCIUM

Lrmp/Jaw1 is Expressed in Sweet, Bitter, and Umami Receptor-Expressing Cells

(2010) Y. Shindo et al.   CHEMICAL SENSES

Apoptosis Protection by Mcl-1 and Bcl-2 Modulation of Inositol 1,4,5-Trisphosphate Receptor-dependent Ca2+Signaling

(2010) Emily F. Eckenrode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined Phosphoinositide and Ca2+Signals Mediating Receptor Specificity toward Neuronal Ca2+Channels

(2010) Oleg Zaika et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-terminal domain of the type 1 Ins(1,4,5)P3 receptor stably expressed in MDCK cells interacts with myosin IIA and alters epithelial cell morphology

(2010) M. C. Hours et al.   JOURNAL OF CELL SCIENCE

Positive regulation of inositol 1,4,5-trisphosphate-induced ca2+release by mammalian target of rapamycin (mTOR) in RINm5F cells

(2010) Marc-Olivier Frégeau et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Type 1 IP3receptors activate BKCachannels via local molecular coupling in arterial smooth muscle cells

(2010) Guiling Zhao et al.   JOURNAL OF GENERAL PHYSIOLOGY

Identification of RanBP 9/10 as Interacting Partners for Protein Kinase C (PKC)  /  and the D1 Dopamine Receptor: Regulation of PKC-Mediated Receptor Phosphorylation

(2010) E. B. Rex et al.   MOLECULAR PHARMACOLOGY

Mechanism of ER Stress-Induced Brain Damage by IP3 Receptor

(2010) Takayasu Higo et al.   NEURON

Gene Knock-Outs of Inositol 1,4,5-Trisphosphate Receptors Types 1 and 2 Result in Perturbation of Cardiogenesis

(2010) Keiko Uchida et al.   PLoS One

ER Calcium and Alzheimer's Disease: In a State of Flux

(2010) M. P. Mattson   Science Signaling

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

(2010) K.-H. Cheung et al.   Science Signaling

An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal

(2009) Srinivas Honnappa et al.   CELL

Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation

(2009) Veerle Vanderheyden et al.   CELL CALCIUM

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

Insulin Promotes the Association of Heat Shock Protein 90 with the Inositol 1,4,5-Trisphosphate Receptor to Dampen Its Ca2+Release Activity

(2009) Nathalie Nguyen et al.   ENDOCRINOLOGY

Protein-tyrosine Phosphatase-α and Src Functionally Link Focal Adhesions to the Endoplasmic Reticulum to Mediate Interleukin-1-induced Ca2+Signaling

(2009) Qin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-protein-coupled Receptor Kinase-interacting Proteins Inhibit Apoptosis by Inositol 1,4,5-Triphosphate Receptor-mediated Ca2+Signal Regulation

(2009) Songbai Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Endoplasmic Reticulum (ER) Membrane Complex Composed of SPFH1 and SPFH2 Mediates the ER-associated Degradation of Inositol 1,4,5-Trisphosphate Receptors

(2009) Margaret M. P. Pearce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPC3 Regulates Agonist-stimulated Ca2+Mobilization by Mediating the Interaction between Type I Inositol 1,4,5-Trisphosphate Receptor, RACK1, and Orai1

(2009) Geoffrey E. Woodard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Golgi Antiapoptotic Protein Modulates Intracellular Calcium Fluxes

(2009) Fabrizio de Mattia et al.   MOLECULAR BIOLOGY OF THE CELL

Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+

(2009) Taufiq-Ur-Rahman et al.   NATURE

Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells

(2009) I. F. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart

(2009) J. D. Scott et al.   SCIENCE

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells

(2008) Premanand C. Sundivakkam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation

(2008) Veerle Vanderheyden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inositol trisphosphate and calcium signalling mechanisms

(2008) Michael J. Berridge   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs

(2008) Junya Ito et al.   DEVELOPMENTAL BIOLOGY

80K-H Interacts with Inositol 1,4,5-Trisphosphate (IP3) Receptors and Regulates IP3-induced Calcium Release Activity

(2008) Katsuhiro Kawaai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective coupling of type 6 adenylyl cyclase with type 2 IP3receptors mediates direct sensitization of IP3receptors by cAMP

(2008) Stephen C. Tovey et al.   JOURNAL OF CELL BIOLOGY

Revisiting ankyrin–InsP3receptor interactions: Ankyrin‐B associates with the cytoplasmic N‐terminus of the InsP3receptor

(2008) Crystal F. Kline et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis

(2008) T. Szado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+ signalling in plants and green algae – changing channels

(2008) Glen L. Wheeler et al.   TRENDS IN PLANT SCIENCE

Intracellular Ca2+ store depletion induces the formation of macromolecular complexes involving hTRPC1, hTRPC6, the type II IP3 receptor and SERCA3 in human platelets

(2007) Pedro C. Redondo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH