Sevoflurane exposure may cause dysplasia of dendritic spines and result in fine motor dysfunction in developing mouse through the PI3K/AKT/mTOR pathway

Regulation of CRMP2 by Cdk5 and GSK-3β participates in sevoflurane-induced dendritic development abnormalities and cognitive dysfunction in developing rats

(2021) Zhaoxia Liao et al.   TOXICOLOGY LETTERS

The inhibition of mammalian target of rapamycin (mTOR) in improving inflammatory response after traumatic brain injury

(2021) Michela Campolo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting PI3K-AKT/mTOR signaling in the prevention of autism

(2021) Aarti Sharma et al.   NEUROCHEMISTRY INTERNATIONAL

Insulin-Like Growth Factor-1 Down-Regulates the Phosphorylation of FXYD1 and Rescues Behavioral Deficits in a Mouse Model of Rett Syndrome

(2020) Zhe-Feng Yuan et al.   Frontiers in Neuroscience

Maf1 regulates dendritic morphogenesis and influences learning and memory

(2020) Kui Chen et al.   Cell Death & Disease

Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer’s Disease

(2020) Wen Yang et al.   Oxidative Medicine and Cellular Longevity

Sevoflurane increases intracellular calcium to induce mitochondrial injury and neuroapoptosis

(2020) Xiaoqiu Zhu et al.   TOXICOLOGY LETTERS

Patterns of neuropsychological changes after general anaesthesia in young children: secondary analysis of the Mayo Anesthesia Safety in Kids study

(2019) Michael J. Zaccariello et al.   BRITISH JOURNAL OF ANAESTHESIA

Mild hypothermia ameliorates anesthesia toxicity in the neonatal macaque brain

(2019) Chrysanthy Ikonomidou et al.   NEUROBIOLOGY OF DISEASE

MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning

(2019) Rimante Minkeviciene et al.   Frontiers in Molecular Neuroscience

Clinical Evidence for Any Effect of Anesthesia on the Developing Brain

(2018) Andrew J. Davidson et al.   ANESTHESIOLOGY

Remodeling of the number and structure of dendritic spines in the medial amygdala: From prepubertal sexual dimorphism to puberty and effect of sexual experience in male rats

(2018) Mariana Zancan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Sevoflurane post-conditioning attenuates traumatic brain injury-induced neuronal apoptosis by promoting autophagy via the PI3K/AKT signaling pathway

(2018) Hefan He et al.   Drug Design Development and Therapy

Inhibition of protein tyrosine phosphatase 1B protects against sevoflurane-induced neurotoxicity mediated by ER stress in developing brain

(2018) Bin Liu et al.   BRAIN RESEARCH BULLETIN

Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells

(2017) Kwang-Youn Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity

(2017) James Gilbert et al.   Frontiers in Cellular Neuroscience

Neuronal apoptosis may not contribute to the long-term cognitive dysfunction induced by a brief exposure to 2% sevoflurane in developing rats

(2016) Yi Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis

(2016) Noemí Pallas‐Bazarra et al.   EMBO JOURNAL

Association Between a Single General Anesthesia Exposure Before Age 36 Months and Neurocognitive Outcomes in Later Childhood

(2016) Lena S. Sun et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

KU0063794, a Dual mTORC1 and mTORC2 Inhibitor, Reduces Neural Tissue Damage and Locomotor Impairment After Spinal Cord Injury in Mice

(2016) Marika Cordaro et al.   MOLECULAR NEUROBIOLOGY

Lasting impact of general anaesthesia on the brain: mechanisms and relevance

(2016) Laszlo Vutskits et al.   NATURE REVIEWS NEUROSCIENCE

Mushroom spine dynamics in medium spiny neurons of dorsal striatum associated with memory of moderate and intense training

(2016) Paola C. Bello-Medina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes

(2015) Wen-Jie Bian et al.   CELL

The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders

(2015) Jian Guan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Neurotoxicity of Generic Anesthesia Agents in Infants and Children

(2015) Bruce M. Psaty et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The human medial amygdala: structure, diversity, and complexity of dendritic spines

(2015) Aline Dall'Oglio et al.   JOURNAL OF ANATOMY

Acute and Long-Term Effects of Brief Sevoflurane Anesthesia During the Early Postnatal Period in Rats

(2015) Lin Qiu et al.   TOXICOLOGICAL SCIENCES

Sevoflurane Induces Tau Phosphorylation and Glycogen Synthase Kinase 3β Activation in Young Mice

(2014) Guorong Tao et al.   ANESTHESIOLOGY

Neurodevelopmental Outcomes After Initial Childhood Anesthetic Exposure Between Ages 3 and 10 Years

(2014) Caleb H. Ing et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Effect of General Anesthesia in Infancy on Long-Term Recognition Memory in Humans and Rats

(2014) Greg Stratmann et al.   NEUROPSYCHOPHARMACOLOGY

Protective Effect of FTY720 Against Sevoflurane-Induced Developmental Neurotoxicity in Rats

(2013) Hui Zhou et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

N-stearoyl-l-tyrosine ameliorates sevoflurane induced neuroapoptosis via MEK/ERK1/2 MAPK signaling pathway in the developing brain

(2013) Wen-Yuan Wang et al.   NEUROSCIENCE LETTERS

Attention-Deficit/Hyperactivity Disorder After Early Exposure to Procedures Requiring General Anesthesia

(2012) Juraj Sprung et al.   MAYO CLINIC PROCEEDINGS

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

(2011) Cheng-Che Lee et al.   NEUROPHARMACOLOGY

Guided motor training induces dendritic spine plastic changes in adult rat cerebellar purkinje cells

(2011) Ignacio González-Burgos et al.   NEUROSCIENCE LETTERS

Cognitive and Behavioral Outcomes After Early Exposure to Anesthesia and Surgery

(2011) R. P. Flick et al.   PEDIATRICS

Volatile Anesthetics Rapidly Increase Dendritic Spine Density in the Rat Medial Prefrontal Cortex during Synaptogenesis

(2010) Adrian Briner et al.   ANESTHESIOLOGY

Early childhood general anaesthesia exposure and neurocognitive development

(2010) L Sun   BRITISH JOURNAL OF ANAESTHESIA

Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

(2010) Takeshi Nishijima et al.   NEURON

Behavior and Development in Children and Age at the Time of First Anesthetic Exposure

(2009) Cor J. Kalkman et al.   ANESTHESIOLOGY

Neonatal Exposure to Sevoflurane Induces Abnormal Social Behaviors and Deficits in Fear Conditioning in Mice

(2009) Maiko Satomoto et al.   ANESTHESIOLOGY

Early Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort

(2009) Robert T. Wilder et al.   ANESTHESIOLOGY

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

(2009) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Potential Neurotoxicity of Ketamine in the Developing Rat Brain

(2009) Xiaoju Zou et al.   TOXICOLOGICAL SCIENCES