The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders

Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1

(2014) Jian Guan et al.   Scientific Reports

Mechanism of Action for NNZ-2566 Anti-inflammatory Effects Following PBBI Involves Upregulation of Immunomodulator ATF3

(2013) Casandra M. Cartagena et al.   NEUROMOLECULAR MEDICINE

Molecular mechanism underlying the cerebral effect of Gly-Pro-Glu tripeptide bound to l-dopa in a Parkinson’s animal model

(2012) Alba Minelli et al.   AMINO ACIDS

Effects of intracerebroventricular application of insulin-like growth factor 1 and its N-terminal tripeptide on cerebral recovery following cardiac arrest in rats

(2012) Jürgen Knapp et al.   RESUSCITATION

Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide

(2011) Sook-Eun Park et al.   Journal of Neuroinflammation

NNZ-2591, a novel diketopiperazine, prevented scopolamine-induced acute memory impairment in the adult rat

(2010) Jian Guan et al.   BEHAVIOURAL BRAIN RESEARCH

Mecasermin (recombinant human insulin-like growth factor I)

(2009) Arlan L. Rosenbloom   ADVANCES IN THERAPY

IGF-1 derived small neuropeptides and analogues: a novel strategy for the development of pharmaceuticals for neurological conditions

(2009) Jian Guan et al.   BRITISH JOURNAL OF PHARMACOLOGY

NNZ-2566, a Glypromate Analog, Attenuates Brain Ischemia-Induced Non-Convulsive Seizures in Rats

(2009) Xi-Chun M Lu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The N-terminal tripeptide of insulin-like growth factor-I protects against β-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3β modulation

(2009) Emma Burgos-Ramos et al.   JOURNAL OF NEUROCHEMISTRY

NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats

(2009) Hans H Wei et al.   Journal of Neuroinflammation

NNZ-2566, a Glypromate Analog, Improves Functional Recovery and Attenuates Apoptosis and Inflammation in a Rat Model of Penetrating Ballistic-Type Brain Injury

(2009) Xi-Chun May Lu et al.   JOURNAL OF NEUROTRAUMA

NNZ-2566: A Gly–Pro–Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke

(2009) Michael J. Bickerdike et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Delayed peripheral administration of the N-terminal tripeptide of IGF-1 (GPE) reduces brain damage following microsphere induced embolic damage in young adult and aged rats

(2009) Shlomo Shapira et al.   NEUROSCIENCE LETTERS

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

(2008) Leah R Hanson et al.   BMC NEUROSCIENCE