The inhibition of mammalian target of rapamycin (mTOR) in improving inflammatory response after traumatic brain injury

Role of ABT888, a Novel Poly(ADP-Ribose) Polymerase (PARP) Inhibitor in Countering Autophagy and Apoptotic Processes Associated to Spinal Cord Injury

(2020) Giovanna Casili et al.   MOLECULAR NEUROBIOLOGY

Oxidative stress: Major threat in traumatic brain injury

(2018) Nidhi Khatri et al.   CNS & Neurological Disorders-Drug Targets

Dimethyl Fumarate Attenuates Neuroinflammation and Neurobehavioral Deficits Induced by Experimental Traumatic Brain Injury

(2018) Giovanna Casili et al.   JOURNAL OF NEUROTRAUMA

Sphingosine 1-Phosphate Receptor Subtype 1 as a Therapeutic Target for Brain Trauma

(2018) Salvatore Cuzzocrea et al.   JOURNAL OF NEUROTRAUMA

Beneficial Effects of Early mTORC1 Inhibition after Traumatic Brain Injury

(2016) Ina Nikolaeva et al.   JOURNAL OF NEUROTRAUMA

Neuroprotective Effects of Co-UltraPEALut on Secondary Inflammatory Process and Autophagy Involved in Traumatic Brain Injury

(2016) Marika Cordaro et al.   JOURNAL OF NEUROTRAUMA

KU0063794, a Dual mTORC1 and mTORC2 Inhibitor, Reduces Neural Tissue Damage and Locomotor Impairment After Spinal Cord Injury in Mice

(2016) Marika Cordaro et al.   MOLECULAR NEUROBIOLOGY

Traumatic Brain Injury Leads to Development of Parkinson's Disease Related Pathology in Mice

(2016) Daniela Impellizzeri et al.   Frontiers in Neuroscience

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Balanced mTORC1 Activity in Oligodendrocytes Is Required for Accurate CNS Myelination

(2014) F. Lebrun-Julien et al.   JOURNAL OF NEUROSCIENCE

Interactions of Oxidative Stress and Neurovascular Inflammation in the Pathogenesis of Traumatic Brain Injury

(2014) P. M. Abdul-Muneer et al.   MOLECULAR NEUROBIOLOGY

mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells

(2014) Camilla Norrmén et al.   Cell Reports

Long-Term Upregulation of Inflammation and Suppression of Cell Proliferation in the Brain of Adult Rats Exposed to Traumatic Brain Injury Using the Controlled Cortical Impact Model

(2013) Sandra A. Acosta et al.   PLoS One

A Comparison of Ku0063794, a Dual mTORC1 and mTORC2 Inhibitor, and Temsirolimus in Preclinical Renal Cell Carcinoma Models

(2013) Hao Zhang et al.   PLoS One

Influence of Post-Traumatic Stress Disorder on Neuroinflammation and Cell Proliferation in a Rat Model of Traumatic Brain Injury

(2013) Sandra A. Acosta et al.   PLoS One

Microglia Activation as a Biomarker for Traumatic Brain Injury

(2013) Diana G. Hernandez-Ontiveros et al.   Frontiers in Neurology

Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries

(2012) Aruni S. Arachchige Don et al.   DRUG DISCOVERY TODAY

Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice

(2011) C.-L. Luo et al.   NEUROSCIENCE

The Complexes of Mammalian Target of Rapamycin

(2010) Hongyu Zhou et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Role of microglia in neurotrauma

(2010) David J. Loane et al.   Neurotherapeutics

Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies

(2010) David J. Loane et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Serum deprivation-induced reactive oxygen species production is mediated by Romo1

(2009) Seung Baek Lee et al.   APOPTOSIS

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

(2009) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

A Novel Protein Complex in Membrane Rafts Linking the NR2B Glutamate Receptor and Autophagy Is Disrupted following Traumatic Brain Injury

(2009) Gregory E. Bigford et al.   JOURNAL OF NEUROTRAUMA

Traumatic Brain Injury and Long-Term Quality of Life: Findings from an Australian Study

(2009) Graeme Hawthorne et al.   JOURNAL OF NEUROTRAUMA

Oral rapamycin reduces tumour burden and vascularization inLkb1+/−mice

(2009) James Robinson et al.   JOURNAL OF PATHOLOGY

Simvastatin-Mediated Upregulation of VEGF and BDNF, Activation of the PI3K/Akt Pathway, and Increase of Neurogenesis Are Associated with Therapeutic Improvement after Traumatic Brain Injury

(2008) Hongtao Wu et al.   JOURNAL OF NEUROTRAUMA