Targeting PI3K-AKT/mTOR signaling in the prevention of autism

Neuroprotective Effect of α-Mangostin in Ameliorating Propionic Acid-Induced Experimental Model of Autism in Wistar Rats

(2021) Aarti Tiwari et al.   Brain Sciences

Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism

(2021) S Rahi et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Downregulated AKT-mTOR signaling pathway proteins in dorsolateral prefrontal cortex in Schizophrenia

(2020) Radhika Chadha et al.   NEUROPSYCHOPHARMACOLOGY

TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling

(2020) Pauline Martin et al.   Molecular Autism

Microglia Mediated Neuroinflammation: Focus on PI3K Modulation

(2020) Antonia Cianciulli et al.   Biomolecules

Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential

(2020) Masahito Morimoto et al.   PLoS One

Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

(2020) Fei Xu et al.   Cell and Bioscience

Update on Atypicalities of Central Nervous System in Autism Spectrum Disorder

(2020) Ahmad Naqib Shuid et al.   Brain Sciences

Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex

(2020) Hiroaki Sacai et al.   Nature Communications

The Autism‐Related lncRNA MSNP1AS Regulates Moesin Protein to Influence the RhoA , Rac1, and PI3K /Akt Pathways and Regulate the Structure and Survival of Neurons

(2020) Ting Luo et al.   Autism Research

Understanding Abnormal SMO-SHH Signaling in Autism Spectrum Disorder: Potential Drug Target and Therapeutic Goals

(2020) Saloni Rahi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero

(2019) Hiroko Kotajima-Murakami et al.   Molecular Brain

Critical Roles of the PI3K-Akt-mTOR Signaling Pathway in Apoptosis and Autophagy of Astrocytes Induced by Methamphetamine

(2019) Han-Qing Liu et al.   Open Chemistry

Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism

(2019) Eleonora Rosina et al.   Translational Psychiatry

Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice

(2019) Xiaoliang Xing et al.   Scientific Reports

The Role of PI3K/Akt and ERK in Neurodegenerative Disorders

(2019) Sachchida Nand Rai et al.   NEUROTOXICITY RESEARCH

mTOR Hyperactivity Levels Influence the Severity of Epilepsy and Associated Neuropathology in an Experimental Model of Tuberous Sclerosis Complex and Focal Cortical Dysplasia

(2019) Lena H. Nguyen et al.   JOURNAL OF NEUROSCIENCE

PI3K isoforms in cell signalling and vesicle trafficking

(2019) Benoit Bilanges et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overcoming Resistance to Selective Serotonin Reuptake Inhibitors: Targeting Serotonin, Serotonin-1A Receptors and Adult Neuroplasticity

(2019) Faranak Vahid-Ansari et al.   Frontiers in Neuroscience

NGL-3 in the regulation of brain development, Akt/GSK3b signaling, long-term depression, and locomotive and cognitive behaviors

(2019) Hyejin Lee et al.   PLOS BIOLOGY

Molecular basis for class side effects associated with PI3K/AKT/mTOR pathway inhibitors

(2019) Ying Zhang et al.   Expert Opinion on Drug Metabolism & Toxicology

< Omega >-3 PUFA Attenuates LPS-Induced Neuro-Injury of Neonatal Rats through the PI3K/AKT Pathway.

(2019) Ji-peng Shi et al.   NEUROSCIENCE

Potential link between the RagA-mTOR-p70S6K axis and depressive-behaviors during bacterial liposaccharide challenge

(2019) Jia Zhao et al.   Journal of Neuroinflammation

Neurobehavioral phenotype of autism spectrum disorder associated with germline heterozygous mutations in PTEN

(2019) Robyn M. Busch et al.   Translational Psychiatry

The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis

(2019) N. Jaiswal et al.   Molecular Metabolism

Propofol Reduces Inflammatory Brain Injury after Subarachnoid Hemorrhage: Involvement of PI3K/Akt Pathway

(2019) Hua-bin Zhang et al.   Journal of Stroke & Cerebrovascular Diseases

Abnormal mTOR Activation in Autism

(2018) Kellen D. Winden et al.   Annual Review of Neuroscience

Cellular stress and apoptosis contribute to the pathogenesis of autism spectrum disorder

(2018) Daoyin Dong et al.   Autism Research

Role of mTOR Complexes in Neurogenesis

(2018) Francesca LiCausi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective Effects of Notoginsenoside R1 via Regulation of the PI3K-Akt-mTOR/JNK Pathway in Neonatal Cerebral Hypoxic–Ischemic Brain Injury

(2018) Liu Tu et al.   NEUROCHEMICAL RESEARCH

Serotonin and serotonin transporter levels in autistic children

(2018) Haidar Abdulamir et al.   SAUDI MEDICAL JOURNAL

Beta-propeller protein-associated neurodegeneration (BPAN) as a genetically simple model of multifaceted neuropathology resulting from defects in autophagy

(2018) Catherine Hong Huan Hor et al.   REVIEWS IN THE NEUROSCIENCES

PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

(2018) Karina Sánchez-Alegría et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

Effect of PI3K/Akt/mTOR signaling pathway on JNK3 in Parkinsonian rats

(2018) Ying Chen et al.   Experimental and Therapeutic Medicine

MECP2 Mutation Interrupts Nucleolin–mTOR–P70S6K Signaling in Rett Syndrome Patients

(2018) Carl O. Olson et al.   Frontiers in Genetics

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them

(2017) Kathrin Leppek et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR inhibitors in the pharmacologic management of tuberous sclerosis complex and their potential role in other rare neurodevelopmental disorders

(2017) David N. Franz et al.   Orphanet Journal of Rare Diseases

Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice

(2017) Xiao Li et al.   PLoS One

Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity

(2017) James Gilbert et al.   Frontiers in Cellular Neuroscience

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

(2017) Michela Palmieri et al.   Nature Communications

mTOR-Dependent Cell Proliferation in the Brain

(2017) Larisa Ryskalin et al.   Biomed Research International

Dynamic Akt/mTOR Signaling in Children with Autism Spectrum Disorder

(2017) Charity Onore et al.   Frontiers in Pediatrics

An Analysis of the Effects and the Molecular Mechanism of Deep Hypothermic Low Flow on Brain Tissue in Mice

(2016) Yuzhong Yang et al.   Annals of Thoracic and Cardiovascular Surgery

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis

(2016) Dah Ihm Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity

(2016) B. L. Lampson et al.   BLOOD

EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy

(2016) Susan Byrne et al.   BRAIN

PI3K/AKT/mTOR-mediated autophagy in the development of autism spectrum disorder

(2016) Jun Zhang et al.   BRAIN RESEARCH BULLETIN

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses

(2016) Andrea K.H. Stavoe et al.   DEVELOPMENTAL CELL

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

(2016) H-J Kim et al.   MOLECULAR PSYCHIATRY

Early Behavioral Abnormalities and Perinatal Alterations of PTEN/AKT Pathway in Valproic Acid Autism Model Mice

(2016) Eun-Jeong Yang et al.   PLoS One

Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling

(2016) Songshan Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism

(2016) Arti B. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation

(2015) Jeyaganesh Rajamanickam et al.   BIOCHEMICAL JOURNAL

Enhancement of LPS-Induced Microglial Inflammation Response via TLR4 Under High Glucose Conditions

(2015) Xiang Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Reward breaks through center-surround inhibition via anterior insula

(2015) Lihui Wang et al.   HUMAN BRAIN MAPPING

Inhibition of mTOR Pathway by Rapamycin Reduces Brain Damage in Rats Subjected to Transient Forebrain Ischemia

(2015) Xiao Yang et al.   International Journal of Biological Sciences

Interleukin-1β plays a role in the pathogenesis of mesial temporal lobe epilepsy through the PI3K/Akt/mTOR signaling pathway in hippocampal neurons

(2015) Zhaohua Xiao et al.   JOURNAL OF NEUROIMMUNOLOGY

Imbalanced Mechanistic Target of Rapamycin C1 and C2 Activity in the Cerebellum of Angelman Syndrome Mice Impairs Motor Function

(2015) J. Sun et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow

(2015) Di Yu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Mitochondrial Dysfunction and Its Relationship with mTOR Signaling and Oxidative Damage in Autism Spectrum Disorders

(2015) Kunio Yui et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

eIF4E/ Fmr1 double mutant mice display cognitive impairment in addition to ASD-like behaviors

(2015) Thu N. Huynh et al.   NEUROBIOLOGY OF DISEASE

Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder

(2015) Amanda K. Tilot et al.   Neurotherapeutics

The Prevalence and Impact of Hyperglycemia and Hyperlipidemia in Patients With Advanced Cancer Receiving Combination Treatment With the Mammalian Target of Rapamycin Inhibitor Temsirolimus and Insulin Growth Factor-Receptor Antibody Cixutumumab

(2015) N. L. Busaidy et al.   ONCOLOGIST

Autism spectrum disorder in tuberous sclerosis complex: searching for risk markers

(2015) Aglaia Vignoli et al.   Orphanet Journal of Rare Diseases

mTOR in Brain Physiology and Pathologies

(2015) Joël Bockaert et al.   PHYSIOLOGICAL REVIEWS

Altered serotonin transporter binding potential in patients with obsessive-compulsive disorder under escitalopram treatment: [11C]DASB PET study

(2015) E. Kim et al.   PSYCHOLOGICAL MEDICINE

A multi-targeted approach to suppress tumor-promoting inflammation

(2015) Abbas K. Samadi et al.   SEMINARS IN CANCER BIOLOGY

Brain overgrowth in disorders of RTK–PI3K–AKT signaling: A mosaic of malformations

(2015) Robert F. Hevner   SEMINARS IN PERINATOLOGY

Characterizing autism spectrum disorders by key biochemical pathways

(2015) Megha Subramanian et al.   Frontiers in Neuroscience

Autism as a Disorder of Biological and Behavioral Rhythms: Toward New Therapeutic Perspectives

(2015) Sylvie Tordjman et al.   Frontiers in Pediatrics

Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid

(2015) Chiara Nicolini et al.   Acta Neuropathologica Communications

All Akt Isoforms (Akt1, Akt2, Akt3) Are Involved in Normal Hearing, but Only Akt2 and Akt3 Are Involved in Auditory Hair Cell Survival in the Mammalian Inner Ear

(2015) Yves Brand et al.   PLoS One

Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation

(2014) Stefan Dröse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Drug-induced pneumonitis in cancer patients treated with mTOR inhibitors: management and insights into possible mechanisms

(2014) Ignacio Duran et al.   Expert Opinion On Drug Safety

Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells

(2014) Márcio Ribeiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

The apoptotic perspective of autism

(2014) Hongen Wei et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders

(2014) Jianling Chen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway

(2014) Hongquan Dong et al.   Journal of Neuroinflammation

Regulation of mitochondrial apoptosis by Pin1 in cancer and neurodegeneration

(2014) Giovanni Sorrentino et al.   MITOCHONDRION

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

The role of TLR4-mediated PTEN/PI3K/AKT/NF-κB signaling pathway in neuroinflammation in hippocampal neurons

(2014) M. Zhao et al.   NEUROSCIENCE

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

(2014) M. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt and mTOR mediate programmed necrosis in neurons

(2014) Q Liu et al.   Cell Death & Disease

Selective Activation of mTORC1 Signaling Recapitulates Microcephaly, Tuberous Sclerosis, and Neurodegenerative Diseases

(2014) Hidetoshi Kassai et al.   Cell Reports

Effects of PI3Kβ overexpression in the hippocampus on synaptic plasticity and spatial learning

(2014) Jun-Hyeok Choi et al.   Molecular Brain

Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins

(2014) Joaquin N. Lugo et al.   Frontiers in Molecular Neuroscience

Identification of Small Exonic CNV from Whole-Exome Sequence Data and Application to Autism Spectrum Disorder

(2013) Christopher S. Poultney et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Duplication ofAKT3as a cause of macrocephaly in duplication 1q43q44

(2013) David Wang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Akt2 Deficiency is Associated with Anxiety and Depressive Behavior in Mice

(2013) Christina Leibrock et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Treadmill exercise ameliorates motor disturbance through inhibition of apoptosis in the cerebellum of valproic acid-induced autistic rat pups

(2013) JI-EUN KIM et al.   Molecular Medicine Reports

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain Injury

(2013) Dongjun Guo et al.   PLoS One

Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

(2013) Kelly Devereaux et al.   PLoS One

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Lack of association of rare functional variants in TSC1/TSC2 genes with autism spectrum disorder

(2013) Samira Bahl et al.   Molecular Autism

Neuronal Autophagy and Neurodevelopmental Disorders

(2013) Kyung-Min Lee et al.   Experimental Neurobiology

Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?

(2012) Rafael A Barreto et al.   BMC NEUROSCIENCE

Impaired induction of long-term potentiation-like plasticity in patients with high-functioning autism and Asperger syndrome

(2012) NIKOLAI H JUNG et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures

(2012) Linglin Chen et al.   EPILEPSIA

The PI3K/Akt pathway is required for LPS activation of microglial cells

(2012) Concetta Saponaro et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosisviamitochondrial-lysosomal cross-talk

(2012) Christian Seitz et al.   INTERNATIONAL JOURNAL OF CANCER

Pten Deletion in Adult Hippocampal Neural Stem/Progenitor Cells Causes Cellular Abnormalities and Alters Neurogenesis

(2012) A. Amiri et al.   JOURNAL OF NEUROSCIENCE

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

(2012) Peter T. Tsai et al.   NATURE

Exaggerated translation causes synaptic and behavioural aberrations associated with autism

(2012) Emanuela Santini et al.   NATURE

Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex

(2012) R. Michelle Reith et al.   NEUROBIOLOGY OF DISEASE

Translation Initiation Factor AteIF(iso)4E Is Involved in Selective mRNA Translation in Arabidopsis Thaliana Seedlings

(2012) Ana Valeria Martínez-Silva et al.   PLoS One

Mitochondrial Dysfunction in Pten Haplo-Insufficient Mice with Social Deficits and Repetitive Behavior: Interplay between Pten and p53

(2012) Eleonora Napoli et al.   PLoS One

PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1

(2012) Chong Kiat Goo et al.   PLoS One

Low brain serotonin transporter binding in major depressive disorder

(2012) Andrew B. Newberg et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Age-Dependent Brain Gene Expression and Copy Number Anomalies in Autism Suggest Distinct Pathological Processes at Young Versus Mature Ages

(2012) Maggie L. Chow et al.   PLoS Genetics

Epidemiology of Autism Spectrum Disorders in Adults in the Community in England

(2011) Traolach S. Brugha et al.   ARCHIVES OF GENERAL PSYCHIATRY

Phosphatidylinositol 3-kinase/Akt Signaling Pathway Mediates Acupuncture-Induced Dopaminergic Neuron Protection and Motor Function Improvement in a Mouse Model of Parkinson's Disease

(2011) Seung-Nam Kim et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Protein levels of β-catenin and activation state of glycogen synthase kinase-3β in major depression. A study with postmortem prefrontal cortex

(2011) Félicien Karege et al.   JOURNAL OF AFFECTIVE DISORDERS

Mutations causing syndromic autism define an axis of synaptic pathophysiology

(2011) Benjamin D. Auerbach et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis

(2011) Sharon S. McDaniel et al.   NEUROSCIENCE LETTERS

Atg8: an autophagy-related ubiquitin-like protein family

(2011) Tomer Shpilka et al.   GENOME BIOLOGY

Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT)

(2010) Meredith A Fox et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients

(2010) L. A. V. Magno et al.   GENES BRAIN AND BEHAVIOR

Phosphatidylinositol 3-Kinase Facilitates Microtubule-dependent Membrane Transport for Neuronal Growth Cone Guidance

(2010) Hiroki Akiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome

(2010) C. Gross et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects

(2010) Ashfaq M. Sheikh et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Postnatal Deamidation of 4E-BP2 in Brain Enhances Its Association with Raptor and Alters Kinetics of Excitatory Synaptic Transmission

(2010) Michael Bidinosti et al.   MOLECULAR CELL

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

Tsc2-Rheb signaling regulates EphA-mediated axon guidance

(2010) Duyu Nie et al.   NATURE NEUROSCIENCE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

GSK3 Influences Social Preference and Anxiety-Related Behaviors during Social Interaction in a Mouse Model of Fragile X Syndrome and Autism

(2010) Marjelo A. Mines et al.   PLoS One

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

The Akt isoforms are present at distinct subcellular locations

(2009) Stacey A. Santi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

(2009) Werner J.H. Koopman et al.   ANTIOXIDANTS & REDOX SIGNALING

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

(2009) Jeffrey J. Hutsler et al.   BRAIN RESEARCH

The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly

(2009) Elizabeth A Varga et al.   GENETICS IN MEDICINE

Autophagy promotes synapse development inDrosophila

(2009) Wei Shen et al.   JOURNAL OF CELL BIOLOGY

Tuberous Sclerosis Complex Activity Is Required to Control Neuronal Stress Responses in an mTOR-Dependent Manner

(2009) A. Di Nardo et al.   JOURNAL OF NEUROSCIENCE

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

(2009) Kiran Bhaskar et al.   Molecular Neurodegeneration

Translational Control of Long-Lasting Synaptic Plasticity and Memory

(2009) Mauro Costa-Mattioli et al.   NEURON

Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects

(2009) A.M. Sheikh et al.   NEUROSCIENCE

Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia

(2009) E. Santini et al.   Science Signaling

Akt/GSK3 Signaling in the Action of Psychotropic Drugs

(2008) Jean-Martin Beaulieu et al.   Annual Review of Pharmacology and Toxicology

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Cerebellar Disorders in Childhood: Cognitive Problems

(2008) Maja Steinlin   CEREBELLUM

S6K1 Phosphorylates and Regulates Fragile X Mental Retardation Protein (FMRP) with the Neuronal Protein Synthesis-dependent Mammalian Target of Rapamycin (mTOR) Signaling Cascade

(2008) Usha Narayanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex

(2008) L. Sui et al.   LEARNING & MEMORY

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

(2008) Dan Ehninger et al.   NATURE MEDICINE

Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive Behavior

(2008) Charles A. Hoeffer et al.   NEURON

Mitochondrial Disease in Autism Spectrum Disorder Patients: A Cohort Analysis

(2008) Jacqueline R. Weissman et al.   PLoS One

Role of GSK3  in behavioral abnormalities induced by serotonin deficiency

(2008) J.-M. Beaulieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of mTOR in physiology and pathology of the nervous system

(2007) Lukasz Swiech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS