Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer’s Disease

Traditional herbal medicine-derived sulforaphene promotes mitophagic cell death in lymphoma cells through CRM1-mediated p62/SQSTM1 accumulation and AMPK activation

(2018) Haina Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Sulforaphane Inhibits the Generation of Amyloid-β Oligomer and Promotes Spatial Learning and Memory in Alzheimer’s Disease (PS1V97L) Transgenic Mice

(2018) Ting-Ting Hou et al.   JOURNAL OF ALZHEIMERS DISEASE

Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer’s Rat Model

(2018) CHONGYUN WU et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease

(2018) Siyoung Lee et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity

(2018) Die Pu et al.   NEUROSCIENCE

Induction of Apoptosis and Cytotoxicity by Isothiocyanate Sulforaphene in Human Hepatocarcinoma HepG2 Cells

(2018) Saie Kntayya et al.   Nutrients

BDNF, TNFα, HSP90, CFH, and IL-10 Serum Levels in Patients with Early or Late Onset Alzheimer's Disease or Mild Cognitive Impairment

(2018) Duygu Gezen-Ak et al.   JOURNAL OF ALZHEIMERS DISEASE

Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells

(2017) Anna Pawlik et al.   PHYTOMEDICINE

Identification of the Tau phosphorylation pattern that drives its aggregation

(2017) Clément Despres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex Differences in the Cognitive and Hippocampal Effects of Streptozotocin in an Animal Model of Sporadic AD

(2017) Jian Bao et al.   Frontiers in Aging Neuroscience

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Intracerebroventricular Streptozotocin as a Model of Alzheimer’s Disease: Neurochemical and Behavioral Characterization in Mice

(2016) Katherine Garcia Ravelli et al.   NEUROTOXICITY RESEARCH

Sulforaphene identified from radish (Raphanus sativus L.) seeds possesses antimicrobial properties against multidrug-resistant bacteria and methicillin-resistant Staphylococcus aureus

(2016) Sooyeon Lim et al.   Journal of Functional Foods

The natural compound sulforaphene, as a novel anticancer reagent, targeting PI3K-AKT signaling pathway in lung cancer

(2016) Ming Yang et al.   Oncotarget

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Neuroprotective Effects of Sulforaphane on Cholinergic Neurons in Mice with Alzheimer’s Disease-Like Lesions

(2014) Rui Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease

(2014) Yasuko Kitagishi et al.   Alzheimers Research & Therapy

Sustained Interleukin-1  Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

(2013) S. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

(2013) S. Mondragón-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neuroinflammation: The role and consequences

(2013) Monty Lyman et al.   NEUROSCIENCE RESEARCH

Preparative separation and purification of sulforaphene from radish seeds by high-speed countercurrent chromatography

(2012) Pengqun Kuang et al.   FOOD CHEMISTRY

Glycogen synthase kinase-3β regulates anti-inflammatory property of fluoxetine

(2012) Hui-Chen Su et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research

(2012) Melita Salkovic-Petrisic et al.   JOURNAL OF NEURAL TRANSMISSION

Glucosinolates and isothiocyanates in health and disease

(2012) Albena T. Dinkova-Kostova et al.   TRENDS IN MOLECULAR MEDICINE

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Glycogen synthase kinase-3β inactivation inhibits tumor necrosis factor-α production in microglia by modulating nuclear factor κB and MLK3/JNK signaling cascades

(2011) Mei-Jen Wang et al.   Journal of Neuroinflammation

Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?

(2011) Markel Olabarria et al.   Molecular Neurodegeneration

Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophages

(2011) YAN-FANG XIAN et al.   Experimental and Therapeutic Medicine

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Anti-inflammatory Role of Microsomal Prostaglandin E Synthase-1 in a Model of Neuroinflammation

(2010) Christian Brenneis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

(2010) Daniel C Lee et al.   Journal of Neuroinflammation

Expression of the apoptosis-related proteins caspase-3 and NF-κB in the hippocampus of Tg2576 mice

(2010) Yan-Li Niu et al.   Neuroscience Bulletin

Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells

(2009) Wei-Ching Huang et al.   IMMUNOLOGY

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity

(2008) Christopher J. Yuskaitis et al.   CELLULAR SIGNALLING

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING