Lasting impact of general anaesthesia on the brain: mechanisms and relevance

Anesthesia with Isoflurane Increases Amyloid Pathology in Mice Models of Alzheimer'S Disease

(2017) Juan Perucho et al.   JOURNAL OF ALZHEIMERS DISEASE

Coronary Artery Bypass Surgery Provokes Alzheimer's Disease-Like Changes in the Cerebrospinal Fluid

(2017) András Palotás et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammation Increases Neuronal Sensitivity to General Anesthetics

(2016) Sinziana Avramescu et al.   ANESTHESIOLOGY

The Fallacy of Persistent Postoperative Cognitive Decline

(2016) Michael S. Avidan et al.   ANESTHESIOLOGY

Peri- and postoperative cognitive and consecutive functional problems of elderly patients

(2016) Anika Müller et al.   Current Opinion in Critical Care

Association Between a Single General Anesthesia Exposure Before Age 36 Months and Neurocognitive Outcomes in Later Childhood

(2016) Lena S. Sun et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Anesthesia Exposure and Risk of Dementia and Alzheimer's Disease: A Prospective Study

(2016) Erin J. Aiello Bowles et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial

(2016) Andrew J Davidson et al.   LANCET

Multiple sevoflurane exposures in infant monkeys do not impact the mother-infant bond

(2016) Jessica Raper et al.   NEUROTOXICOLOGY AND TERATOLOGY

Perioperative Neurotoxicity in the Elderly

(2015) Niccolò Terrando et al.   ANESTHESIA AND ANALGESIA

Long-term Effects of Single or Multiple Neonatal Sevoflurane Exposures on Rat Hippocampal Ultrastructure

(2015) Levana G. Amrock et al.   ANESTHESIOLOGY

Multiple Anesthetic Exposure in Infant Monkeys Alters Emotional Reactivity to an Acute Stressor

(2015) Jessica Raper et al.   ANESTHESIOLOGY

Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells

(2015) Yue Tian et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neurodevelopment of children exposed to anesthesia: Design of the Mayo Anesthesia Safety in Kids (MASK) study

(2015) Stephen J. Gleich et al.   Contemporary Clinical Trials

Impact of propofol anaesthesia on cytokine expression profiles in the developing rat brain

(2015) Parichehr Kargaran et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Developmental stage-dependent impact of midazolam on calbindin, calretinin and parvalbumin expression in the immature rat medial prefrontal cortex during the brain growth spurt

(2015) Samira F. Osterop et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Hyperexcitability of Rat Thalamocortical Networks after Exposure to General Anesthesia during Brain Development

(2015) M. R. DiGruccio et al.   JOURNAL OF NEUROSCIENCE

Early Exposure to General Anesthesia Disrupts Spatial Organization of Presynaptic Vesicles in Nerve Terminals of the Developing Rat Subiculum

(2015) N. Lunardi et al.   MOLECULAR NEUROBIOLOGY

Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus

(2015) Pavle M. Joksovic et al.   MOLECULAR NEUROBIOLOGY

Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro

(2015) Robert A. Whittington et al.   NEUROBIOLOGY OF AGING

Anesthetic Neurotoxicity — Clinical Implications of Animal Models

(2015) Bob A. Rappaport et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anesthesia and the developing brain: a way forward for clinical research

(2015) Andrew J. Davidson et al.   PEDIATRIC ANESTHESIA

Acute and Long-Term Effects of Brief Sevoflurane Anesthesia During the Early Postnatal Period in Rats

(2015) Lin Qiu et al.   TOXICOLOGICAL SCIENCES

Identifying research priorities in anaesthesia and perioperative care: final report of the joint National Institute of Academic Anaesthesia/James Lind Alliance Research Priority Setting Partnership

(2015) Oliver Boney et al.   BMJ Open

Biomarkers of postoperative delirium and cognitive dysfunction

(2015) Ganna Androsova et al.   Frontiers in Aging Neuroscience

The critical need for defining preclinical biomarkers in Alzheimer's disease

(2014) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Pushing the Standards Forward

(2014) Laszlo Vutskits et al.   ANESTHESIA AND ANALGESIA

The Role of Hippocampal Tau Protein Phosphorylation in Isoflurane-Induced Cognitive Dysfunction in Transgenic APP695 Mice

(2014) Changsheng Li et al.   ANESTHESIA AND ANALGESIA

Sevoflurane Induces Tau Phosphorylation and Glycogen Synthase Kinase 3β Activation in Young Mice

(2014) Guorong Tao et al.   ANESTHESIOLOGY

Comparative Analysis of Outcome Measures Used in Examining Neurodevelopmental Effects of Early Childhood Anesthesia Exposure

(2014) Caleb H. Ing et al.   ANESTHESIOLOGY

Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors

(2014) H. Wang et al.   BRITISH JOURNAL OF ANAESTHESIA

Sustained increase in α5GABAA receptor function impairs memory after anesthesia

(2014) Agnieszka A. Zurek et al.   JOURNAL OF CLINICAL INVESTIGATION

Vitamin C Attenuates Isoflurane-Induced Caspase-3 Activation and Cognitive Impairment

(2014) Baiqi Cheng et al.   MOLECULAR NEUROBIOLOGY

Isoflurane exposure in newborn rats induces long-term cognitive dysfunction in males but not females

(2014) Bradley H. Lee et al.   NEUROPHARMACOLOGY

Infantile Postoperative Encephalopathy: Perioperative Factors as a Cause for Concern

(2014) M. E. McCann et al.   PEDIATRICS

Physiological Disturbance May Contribute to Neurodegeneration Induced by Isoflurane or Sevoflurane in 14 Day Old Rats

(2014) Binbin Wu et al.   PLoS One

Researchers struggle to gauge risks of childhood anesthesia

(2014) Kelly Servick   SCIENCE

Characterization and Quantification of Isoflurane-Induced Developmental Apoptotic Cell Death in Mouse Cerebral Cortex

(2013) George K. Istaphanous et al.   ANESTHESIA AND ANALGESIA

Anesthetics Interfere with Axon Guidance in Developing Mouse Neocortical Neurons In Vitro via a γ-Aminobutyric Acid Type A Receptor Mechanism

(2013) C. David Mintz et al.   ANESTHESIOLOGY

Propofol Anesthesia Impairs the Maturation and Survival of Adult-born Hippocampal Neurons

(2013) Marine Krzisch et al.   ANESTHESIOLOGY

Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment

(2013) Xia Shen et al.   ANESTHESIOLOGY

Early Exposure to General Anesthesia Disturbs Mitochondrial Fission and Fusion in the Developing Rat Brain

(2013) Annalisa Boscolo et al.   ANESTHESIOLOGY

Effects of Anesthetic Isoflurane and Desflurane on Human Cerebrospinal Fluid Aβ and τ Level

(2013) Bin Zhang et al.   ANESTHESIOLOGY

Cell age-specific vulnerability of neurons to anesthetic toxicity

(2013) Rylon D. Hofacer et al.   ANNALS OF NEUROLOGY

Activation of the canonical nuclear factor-κB pathway is involved in isoflurane-induced hippocampal interleukin-1β elevation and the resultant cognitive deficits in aged rats

(2013) Zheng-Qian Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain

(2013) C. Creeley et al.   BRITISH JOURNAL OF ANAESTHESIA

Risk of dementia after anaesthesia and surgery

(2013) Pin-Liang Chen et al.   BRITISH JOURNAL OF PSYCHIATRY

Surgical Incision-Induced Nociception Causes Cognitive Impairment and Reduction in Synaptic NMDA Receptor 2B in Mice

(2013) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Modeling Transformations of Neurodevelopmental Sequences across Mammalian Species

(2013) A. D. Workman et al.   JOURNAL OF NEUROSCIENCE

Delirium in elderly people

(2013) Sharon K Inouye et al.   LANCET

Repeated exposure to propofol potentiates neuroapoptosis and long-term behavioral deficits in neonatal rats

(2013) Deshui Yu et al.   NEUROSCIENCE LETTERS

Early life exposure to sevoflurane impairs adulthood spatial memory in the rat

(2013) Xiaofeng Shen et al.   NEUROTOXICOLOGY

Differential General Anesthetic Effects on Microglial Cytokine Expression

(2013) Xuefei Ye et al.   PLoS One

General Anesthesia

(2012) Laszlo Vutskits   ANESTHESIA AND ANALGESIA

Early Developmental Exposure to Volatile Anesthetics Causes Behavioral Defects in Caenorhabditis elegans

(2012) Katherine R. Gentry et al.   ANESTHESIA AND ANALGESIA

Delayed Environmental Enrichment Reverses Sevoflurane-induced Memory Impairment in Rats

(2012) Jennifer Shih et al.   ANESTHESIOLOGY

Sevoflurane Anesthesia Does Not Impair Acquisition Learning or Memory in the Morris Water Maze in Young Adult and Aged Rats

(2012) Jennifer K. Callaway et al.   ANESTHESIOLOGY

Tau Phosphorylation and Sevoflurane Anesthesia

(2012) Hélène Le Freche et al.   ANESTHESIOLOGY

Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain

(2012) Ansgar M. Brambrink et al.   ANNALS OF NEUROLOGY

Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory

(2012) Yiying Zhang et al.   ANNALS OF NEUROLOGY

Effects of isoflurane-induced anaesthesia on cognitive performance in a mouse model of Alzheimerʼs disease

(2012) Barbara Eckel et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Feasibility and Pilot Study of the Pediatric Anesthesia NeuroDevelopment Assessment (PANDA) Project

(2012) Lena S. Sun et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

Anesthetics and the developing brain: time for a change in practice? A pro/con debate

(2012) Laszlo Vutskits et al.   PEDIATRIC ANESTHESIA

Long-term Differences in Language and Cognitive Function After Childhood Exposure to Anesthesia

(2012) C. Ing et al.   PEDIATRICS

Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation

(2012) Yuanlin Dong et al.   PLoS One

Propofol-Induced Changes in Neurotrophic Signaling in the Developing Nervous System In Vivo

(2012) Jelena Popic et al.   PLoS One

Isoflurane Induces Learning Impairment That Is Mediated by Interleukin 1β in Rodents

(2012) Lin Cao et al.   PLoS One

Anesthetic effects in Alzheimer transgenic mouse models

(2012) Junxia X. Tang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A review of epidemiological evidence for general anesthesia as a risk factor for Alzheimer's disease

(2012) Dallas P. Seitz et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Anesthesia, surgery, illness and Alzheimer's disease

(2012) Roderic G. Eckenhoff et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Effects of Morphine on the Differentiation and Survival of Developing Pyramidal Neurons During the Brain Growth Spurt

(2012) Horace Massa et al.   TOXICOLOGICAL SCIENCES

Anesthesia in presymptomatic Alzheimer’s disease: A study using the triple-transgenic mouse model

(2011) Junxia X. Tang et al.   Alzheimers & Dementia

Postoperative Cognitive Dysfunction Is Independent of Type of Surgery and Anesthetic

(2011) Lisbeth Evered et al.   ANESTHESIA AND ANALGESIA

Early Childhood Exposure to Anesthesia and Risk of Developmental and Behavioral Disorders in a Sibling Birth Cohort

(2011) Charles DiMaggio et al.   ANESTHESIA AND ANALGESIA

Comparison of the Neuroapoptotic Properties of Equipotent Anesthetic Concentrations of Desflurane, Isoflurane, or Sevoflurane in Neonatal Mice

(2011) George K. Istaphanous et al.   ANESTHESIOLOGY

Academic Performance in Adolescence after Inguinal Hernia Repair in Infancy

(2011) Tom G. Hansen et al.   ANESTHESIOLOGY

Human Alzheimer and Inflammation Biomarkers after Anesthesia and Surgery

(2011) Junxia X. Tang et al.   ANESTHESIOLOGY

General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain

(2011) Victoria Sanchez et al.   ANESTHESIOLOGY

Developmental Stage-dependent Persistent Impact of Propofol Anesthesia on Dendritic Spines in the Rat Medial Prefrontal Cortex

(2011) Adrian Briner et al.   ANESTHESIOLOGY

Propofol Neurotoxicity Is Mediated by p75 Neurotrophin Receptor Activation

(2011) Matthew L. Pearn et al.   ANESTHESIOLOGY

Resolving postoperative neuroinflammation and cognitive decline

(2011) Niccolò Terrando et al.   ANNALS OF NEUROLOGY

Neonatal exposure to propofol affects BDNF but not CaMKII, GAP-43, synaptophysin and tau in the neonatal brain and causes an altered behavioural response to diazepam in the adult mouse brain

(2011) Emma Pontén et al.   BEHAVIOURAL BRAIN RESEARCH

Postoperative cognitive disorders

(2011) Terri G. Monk et al.   Current Opinion in Critical Care

Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain

(2011) Yi Shu et al.   NEUROBIOLOGY OF DISEASE

The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: The importance of free oxygen radicals and mitochondrial integrity

(2011) A. Boscolo et al.   NEUROBIOLOGY OF DISEASE

Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats

(2011) Daowei Lin et al.   NEUROPHARMACOLOGY

Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys

(2011) M.G. Paule et al.   NEUROTOXICOLOGY AND TERATOLOGY

Cognitive and Behavioral Outcomes After Early Exposure to Anesthesia and Surgery

(2011) R. P. Flick et al.   PEDIATRICS

Propofol Directly Increases Tau Phosphorylation

(2011) Robert A. Whittington et al.   PLoS One

Beyond Anesthetic Properties: The Effects of Isoflurane on Brain Cell Death, Neurogenesis, and Long-Term Neurocognitive Function

(2010) Greg Stratmann et al.   ANESTHESIA AND ANALGESIA

Lower Isoflurane Concentration Affects Spatial Learning and Neurodegeneration in Adult Mice Compared with Higher Concentrations

(2010) Ana M. Valentim et al.   ANESTHESIOLOGY

Volatile Anesthetics Rapidly Increase Dendritic Spine Density in the Rat Medial Prefrontal Cortex during Synaptogenesis

(2010) Adrian Briner et al.   ANESTHESIOLOGY

Isoflurane Does Not Affect Brain Cell Death, Hippocampal Neurogenesis, or Long-term Neurocognitive Outcome in Aged Rats

(2010) Greg Stratmann et al.   ANESTHESIOLOGY

Short-term Memory Impairment after Isoflurane in Mice Is Prevented by the α5 γ-Aminobutyric Acid Type A Receptor Inverse Agonist L-655,708

(2010) Bechara J. Saab et al.   ANESTHESIOLOGY

Isoflurane-induced Neuroapoptosis in the Neonatal Rhesus Macaque Brain

(2010) Ansgar M. Brambrink et al.   ANESTHESIOLOGY

Isoflurane Neurotoxicity Is Mediated by p75NTR-RhoA Activation and Actin Depolymerization

(2010) Brian P. Lemkuil et al.   ANESTHESIOLOGY

Role of interleukin-1β in postoperative cognitive dysfunction

(2010) Mario Cibelli et al.   ANNALS OF NEUROLOGY

Isoflurane Anesthesia Induced Persistent, Progressive Memory Impairment, Caused a Loss of Neural Stem Cells, and Reduced Neurogenesis in Young, but Not Adult, Rodents

(2010) Changlian Zhu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

(2010) Wei Deng et al.   NATURE REVIEWS NEUROSCIENCE

The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β

(2010) Xu Wu et al.   NEUROBIOLOGY OF AGING

Tumor necrosis factor-  triggers a cytokine cascade yielding postoperative cognitive decline

(2010) N. Terrando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Consensus Statement: First International Workshop on Anesthetics and Alzheimer’s Disease

(2009) Dmitri Baranov et al.   ANESTHESIA AND ANALGESIA

Inhalational Anesthetics Induce Cell Damage by Disruption of Intracellular Calcium Homeostasis with Different Potencies

(2009) Hui Yang et al.   ANESTHESIOLOGY

The Common Inhalational Anesthetic Isoflurane Induces Apoptosis via Activation of Inositol 1,4,5-Trisphosphate Receptors

(2009) Huafeng Wei et al.   ANESTHESIOLOGY

Predictors of Cognitive Dysfunction after Major Noncardiac Surgery

(2009) Terri G. Monk et al.   ANESTHESIOLOGY

Inhibition of p75 Neurotrophin Receptor Attenuates Isoflurane-mediated Neuronal Apoptosis in the Neonatal Central Nervous System

(2009) Brian P. Head et al.   ANESTHESIOLOGY

Dexmedetomidine Attenuates Isoflurane-induced Neurocognitive Impairment in Neonatal Rats

(2009) Robert D. Sanders et al.   ANESTHESIOLOGY

Nitrous Oxide Plus Isoflurane Induces Apoptosis and Increases β-Amyloid Protein Levels

(2009) Yu Zhen et al.   ANESTHESIOLOGY

Isoflurane Differentially Affects Neurogenesis and Long-term Neurocognitive Function in 60-day-old and 7-day-old Rats

(2009) Greg Stratmann et al.   ANESTHESIOLOGY

Long-term Consequences of Postoperative Cognitive Dysfunction

(2009) Jacob Steinmetz et al.   ANESTHESIOLOGY

Early Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort

(2009) Robert T. Wilder et al.   ANESTHESIOLOGY

Long-term Cognitive Decline in Older Subjects Was Not Attributable to Noncardiac Surgery or Major Illness

(2009) Michael S. Avidan et al.   ANESTHESIOLOGY

The Common Inhalational Anesthetic Sevoflurane Induces Apoptosis and Increases β-Amyloid Protein Levels

(2009) Yuanlin Dong et al.   ARCHIVES OF NEUROLOGY

Anesthesia, Calcium Homeostasis and Alzheimers Disease

(2009) Huafeng Wei et al.   Current Alzheimer Research

Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia

(2009) Emmanuel Planel et al.   FASEB JOURNAL

The Mitochondrial Pathway of Anesthetic Isoflurane-induced Apoptosis

(2009) Yiying Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Retrospective Cohort Study of the Association of Anesthesia and Hernia Repair Surgery With Behavioral and Developmental Disorders in Young Children

(2009) Charles DiMaggio et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

Relationship between perioperative inflammatory response and postoperative cognitive dysfunction in the elderly

(2009) GuangLun Xie et al.   MEDICAL HYPOTHESES

General Anesthesia Causes Long-Lasting Disturbances in the Ultrastructural Properties of Developing Synapses in Young Rats

(2009) N. Lunardi et al.   NEUROTOXICITY RESEARCH

Anesthetics Rapidly Promote Synaptogenesis during a Critical Period of Brain Development

(2009) Mathias De Roo et al.   PLoS One

Anesthesia and Cognitive Performance in Children: No Evidence for a Causal Relationship

(2009) Meike Bartels et al.   Twin Research and Human Genetics

PRO: Anesthesia-Induced Developmental Neuroapoptosis: Status of the Evidence

(2008) Vesna Jevtovic-Todorovic et al.   ANESTHESIA AND ANALGESIA

Spatial Memory Is Intact in Aged Rats After Propofol Anesthesia

(2008) In Ho Lee et al.   ANESTHESIA AND ANALGESIA

An Assessment of the Effects of General Anesthetics on Developing Brain Structure and Neurocognitive Function

(2008) Andreas W. Loepke et al.   ANESTHESIA AND ANALGESIA

The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid β-protein level in vivo

(2008) Zhongcong Xie et al.   ANNALS OF NEUROLOGY

Postoperative Delirium in the Elderly

(2008) Thomas N. Robinson et al.   ANNALS OF SURGERY

The Inhalation Anesthetic Desflurane Induces Caspase Activation and Increases Amyloid β-Protein Levels under Hypoxic Conditions

(2008) Bin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoflurane-Induced Caspase-3 Activation Is Dependent on Cytosolic Calcium and Can Be Attenuated by Memantine

(2008) G. Zhang et al.   JOURNAL OF NEUROSCIENCE

Anesthesia-Induced Hyperphosphorylation Detaches 3-Repeat Tau from Microtubules without Affecting Their Stability In Vivo

(2008) E. Planel et al.   JOURNAL OF NEUROSCIENCE

An estimation of the global volume of surgery: a modelling strategy based on available data

(2008) Thomas G Weiser et al.   LANCET

Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics

(2007) Shannon L. Bianchi et al.   NEUROBIOLOGY OF AGING

Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain

(2005) Chainllie Young et al.   BRITISH JOURNAL OF PHARMACOLOGY