The role of hypoleptinemia in the psychological and behavioral adaptation to starvation: Implications for anorexia nervosa

Neural substrates of appetitive and aversive prediction error

(2021) Mihaela D. Iordanova et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Identification of novel neurocircuitry through which leptin targets multiple inputs to the dopamine system to reduce food reward seeking

(2021) Azar Omrani et al.   BIOLOGICAL PSYCHIATRY

Gastrointestinal symptoms following treatment for anorexia nervosa: A systematic literature review

(2021) Madeline West et al.   INTERNATIONAL JOURNAL OF EATING DISORDERS

Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism

(2021) Jochen Antel et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Serum IGF1 and linear growth in children with congenital leptin deficiency before and after leptin substitution

(2021) Marianna Beghini et al.   INTERNATIONAL JOURNAL OF OBESITY

The Minnesota Starvation Experiment and Force Feeding of Prisoners—Relying on Unethical Research to Justify the Unjustifiable

(2021) Zohar Lederman et al.   Journal of Bioethical Inquiry

Role of Leptin in the Digestive System

(2021) Min-Hyun Kim et al.   Frontiers in Pharmacology

From Awareness to Action: An Urgent Call to Address the Inadequacy of Treatment for Anorexia Nervosa

(2021) Cynthia M. Bulik   AMERICAN JOURNAL OF PSYCHIATRY

The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction

(2021) Qian Wang et al.   Neuroscience Bulletin

Lateral hypothalamic LEPR neurons drive appetitive but not consummatory behaviors

(2021) Justin N. Siemian et al.   Cell Reports

Association of Brain Reward Response With Body Mass Index and Ventral Striatal-Hypothalamic Circuitry Among Young Women With Eating Disorders

(2021) Guido K. W. Frank et al.   JAMA Psychiatry

Exploratory drive, fear, and anxiety are dissociable and independent components in foraging mice

(2021) Daniel E. Heinz et al.   Translational Psychiatry

Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin

(2021) Francesco Suriano et al.   Microbiome

Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study

(2021) Triinu Peters et al.   Frontiers in Genetics

Leptin Receptor Expressing Neurons in the Substantia Nigra Regulate Locomotion, and in The Ventral Tegmental Area Motivation and Feeding

(2021) Véronne A. J. de Vrind et al.   Frontiers in Endocrinology

When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin

(2021) Kaio Cezar Rodrigues Salum et al.   Frontiers in Endocrinology

Bidirectional Association between Physical Activity and Dopamine Across Adulthood—A Systematic Review

(2021) Adilson Marques et al.   Brain Sciences

New Molecular Targets for Antidepressant Drugs

(2021) Johannes Kornhuber et al.   Pharmaceuticals

Reasons for admission and variance of body weight at referral in female inpatients with anorexia nervosa in Germany

(2021) Triinu Peters et al.   Child and Adolescent Psychiatry and Mental Health

Trends in the Incidence of New-Onset Anorexia Nervosa and Atypical Anorexia Nervosa Among Youth During the COVID-19 Pandemic in Canada

(2021) Holly Agostino et al.   JAMA Network Open

Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial

(2020) James L. Dorling et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Genetic Causes of Severe Childhood Obesity: A Remarkably High Prevalence (≥49%) in an Inbred Population of Pakistan

(2020) Sadia Saeed et al.   DIABETES

Pharmacological treatment of acute-phase anorexia nervosa: Evidence from randomized controlled trials

(2020) Emanuele Cassioli et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Outbreak of anorexia nervosa admissions during the COVID-19 pandemic

(2020) Yasheer Venay Haripersad et al.   ARCHIVES OF DISEASE IN CHILDHOOD

VULNERABLE AND RESILIENT PHENOTYPES IN A MOUSE MODEL OF ANOREXIA NERVOSA

(2020) Jeff A. Beeler et al.   BIOLOGICAL PSYCHIATRY

Does physical activity associated with chronic food restriction alleviate anxiety like behaviour, in female mice?

(2020) Philibert Duriez et al.   HORMONES AND BEHAVIOR

PPARγ-mediated microglial activation phenotype is involved in depressive-like behaviors and neuroinflammation in stressed C57BL/6J and ob/ob mice

(2020) Xiaqing Qin et al.   PSYCHONEUROENDOCRINOLOGY

Leptin signaling in vagal afferent neurons supports the absorption and storage of nutrients from high-fat diet

(2020) Kuei-Pin Huang et al.   INTERNATIONAL JOURNAL OF OBESITY

Leptin regulates exon-specific transcription of the Bdnf gene via epigenetic modifications mediated by an AKT/p300 HAT cascade

(2020) Chen Li et al.   MOLECULAR PSYCHIATRY

Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2

(2020) James L Dorling et al.   NUTRITION REVIEWS

Leptin alters energy intake and fat mass but not energy expenditure in lean subjects

(2020) Pavlina Chrysafi et al.   Nature Communications

Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects

(2020) Gabriella Milos et al.   Translational Psychiatry

Molecular Characterization of Constipation Disease as Novel Phenotypes in CRISPR-Cas9-Generated Leptin Knockout Mice with Obesity

(2020) Ji Eun Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of chronic stress on depressive-like behaviors and JMJD3 expression in the prefrontal cortex and hippocampus of C57BL/6 and ob/ob mice

(2020) Huiran Wu et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Meta-analysis of cognitive and behavioral tests in leptin- and leptin receptor-deficient mice

(2020) Tomofumi Watanabe et al.   NEUROSCIENCE RESEARCH

Behavioral assessment of activity-based-anorexia: how cognition can become the drive wheel

(2019) Jacopo Lamanna et al.   PHYSIOLOGY & BEHAVIOR

Advances in the physiology of gastric emptying

(2019) Raj K. Goyal et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Recent developments in lipodystrophy

(2019) Audrey Melvin et al.   CURRENT OPINION IN LIPIDOLOGY

Role of Leptin in Mood Disorder and Neurodegenerative Disease

(2019) Xiaohan Zou et al.   Frontiers in Neuroscience

Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe Obesity

(2019) Hernan Yupanqui-Lozno et al.   Genes

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

(2019) Hunna J. Watson et al.   NATURE GENETICS

Dopamine D2 receptor overexpression in the nucleus accumbens core induces robust weight loss during scheduled fasting selectively in female mice

(2019) Amanda C. Welch et al.   MOLECULAR PSYCHIATRY

Gut–brain nutrient sensing in food reward

(2018) Ari Shechter et al.   APPETITE

Estrogen receptor β activation within dorsal raphe nucleus reverses anxiety-like behavior induced by food restriction in female rats

(2018) Glenda Viggiano Campos et al.   BEHAVIOURAL BRAIN RESEARCH

Changes in Satiety Hormones in Response to Leptin Treatment in a Patient with Leptin Deficiency

(2018) Christian L. Roth et al.   Hormone Research in Paediatrics

Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency

(2018) Katja Kohlsdorf et al.   INTERNATIONAL JOURNAL OF OBESITY

Targeted inhibition of RAGE reduces amyloid-β influx across the blood-brain barrier and improves cognitive deficits in db/db mice

(2018) Hao Wang et al.   NEUROPHARMACOLOGY

Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes

(2018) Sadia Saeed et al.   Obesity

Severe early onset obesity due to a novel missense mutation in exon 3 of leptin gene in an infant from Northwest India

(2018) Devi Dayal et al.   Journal of Clinical Research in Pediatric Endocrinology

Diagnosis and treatment of lipodystrophy: a step-by-step approach

(2018) D. Araújo-Vilar et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balance

(2018) Alan C. Rupp et al.   Molecular Metabolism

Phenotypic and Genetic Characteristics of Lipodystrophy: Pathophysiology, Metabolic Abnormalities, and Comorbidities

(2018) Baris Akinci et al.   Current Diabetes Reports

Beneficial effects of leptin substitution on impaired eating behavior in lipodystrophy are sustained beyond 150 weeks of treatment

(2018) Janett Püschel et al.   CYTOKINE

Fluorescent blood–brain barrier tracing shows intact leptin transport in obese mice

(2018) Luke Harrison et al.   INTERNATIONAL JOURNAL OF OBESITY

Dopamine System Dysregulation in Major Depressive Disorders

(2017) Pauline Belujon et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A focus on reward in anorexia nervosa through the lens of the activity-based anorexia rodent model

(2017) C. J. Foldi et al.   JOURNAL OF NEUROENDOCRINOLOGY

A molecular census of arcuate hypothalamus and median eminence cell types

(2017) John N Campbell et al.   NATURE NEUROSCIENCE

The Role of Mesolimbic Reward Neurocircuitry in Prevention and Rescue of the Activity-Based Anorexia (ABA) Phenotype in Rats

(2017) Claire J Foldi et al.   NEUROPSYCHOPHARMACOLOGY

Impaired reversal learning in an animal model of anorexia nervosa

(2017) Patricia J. Allen et al.   PHYSIOLOGY & BEHAVIOR

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

(2016) Simin N. Meydani et al.   Aging-US

The multifaceted effects of starvation on arthropod behaviour

(2016) Inon Scharf   ANIMAL BEHAVIOUR

Leptin Substitution in Patients With Lipodystrophy: Neural Correlates for Long-term Success in the Normalization of Eating Behavior

(2016) Haiko Schlögl et al.   DIABETES

Glia: silent partners in energy homeostasis and obesity pathogenesis

(2016) John D. Douglass et al.   DIABETOLOGIA

Lipodystrophy Syndromes

(2016) Iram Hussain et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Mortality in eating disorders - results of a large prospective clinical longitudinal study

(2016) Manfred Maximilian Fichter et al.   INTERNATIONAL JOURNAL OF EATING DISORDERS

The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline

(2016) Rebecca J. Brown et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Homeostasis Meets Motivation in the Battle to Control Food Intake

(2016) Carrie R. Ferrario et al.   JOURNAL OF NEUROSCIENCE

Minireview: CNS Mechanisms of Leptin Action

(2016) Jonathan N. Flak et al.   MOLECULAR ENDOCRINOLOGY

Dynamic GABAergic afferent modulation of AgRP neurons

(2016) Alastair S Garfield et al.   NATURE NEUROSCIENCE

Long-Term Energy Deficit in Mice Causes Long-Lasting Hypothalamic Alterations after Recovery

(2016) Mathieu Méquinion et al.   NEUROENDOCRINOLOGY

Appetite and energy balancing

(2016) Peter J. Rogers et al.   PHYSIOLOGY & BEHAVIOR

Memory impairment is associated with the loss of regular oestrous cycle and plasma oestradiol levels in an activity-based anorexia animal model

(2016) Lisa Paulukat et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults

(2016) Corby K. Martin et al.   JAMA Internal Medicine

Anorexia Reduces GFAP+ Cell Density in the Rat Hippocampus

(2016) Daniel Reyes-Haro et al.   NEURAL PLASTICITY

Anxiety is correlated with running in adolescent female mice undergoing activity-based anorexia.

(2015) Gauri S. Wable et al.   BEHAVIORAL NEUROSCIENCE

Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons

(2015) Maria Fernanda A. Fernandes et al.   Cell Metabolism

Leptin: A Potential Anxiolytic by Facilitation of Fear Extinction

(2015) Wei Wang et al.   CNS Neuroscience & Therapeutics

Exposure to activity-based anorexia impairs contextual learning in weight-restored rats without affecting spatial learning, taste, anxiety, or dietary-fat preference

(2015) Gretha J. Boersma et al.   INTERNATIONAL JOURNAL OF EATING DISORDERS

Modulation of cue-induced firing of ventral tegmental area dopamine neurons by leptin and ghrelin

(2015) G van der Plasse et al.   INTERNATIONAL JOURNAL OF OBESITY

Mood disorders in eating disorder patients: Prevalence and chronology of ONSET

(2015) N. Godart et al.   JOURNAL OF AFFECTIVE DISORDERS

Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene

(2015) Martin Wabitsch et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Role of Astrocytes in Leptin Signaling

(2015) Yuping Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Leptin and the brain: Influences on brain development, cognitive functioning and psychiatric disorders

(2015) Olivia M. Farr et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Biologically Inactive Leptin and Early-Onset Extreme Obesity

(2015) Martin Wabitsch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic variants inLEP,LEPR, andMC4Rexplain 30% of severe obesity in children from a consanguineous population

(2015) Sadia Saeed et al.   Obesity

Recent Advances in Developmental and Risk Factor Research on Eating Disorders

(2015) Jennifer L. Bakalar et al.   Current Psychiatry Reports

Dehydration-Induced Anorexia Reduces Astrocyte Density in the Rat Corpus Callosum

(2015) Daniel Reyes-Haro et al.   NEURAL PLASTICITY

Sex differences in feeding behavior in rats: the relationship with neuronal activation in the hypothalamus

(2015) Atsushi Fukushima et al.   Frontiers in Neuroscience

TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons

(2015) Margaret B. Allison et al.   Molecular Metabolism

20 YEARS OF LEPTIN: Human disorders of leptin action

(2014) I Sadaf Farooqi et al.   JOURNAL OF ENDOCRINOLOGY

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

(2014) Jae Geun Kim et al.   NATURE NEUROSCIENCE

Correction: Leptin Replacement Improves Cognitive Development

(2014) Gilberto J. Paz-Filho et al.   PLoS One

Long-Term Physiological Alterations and Recovery in a Mouse Model of Separation Associated with Time-Restricted Feeding: A Tool to Study Anorexia Nervosa Related Consequences

(2014) Sara Zgheib et al.   PLoS One

Presynaptic Leptin Action Suppresses Excitatory Synaptic Transmission onto Ventral Tegmental Area Dopamine Neurons

(2013) Jennifer L. Thompson et al.   BIOLOGICAL PSYCHIATRY

A novel mutation of the leptin gene in an Indian patient

(2013) S. Thakur et al.   CLINICAL GENETICS

Factors influencing behavior in the forced swim test

(2013) Olena V. Bogdanova et al.   PHYSIOLOGY & BEHAVIOR

Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity

(2013) Sabine Klein et al.   Nature Communications

Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours

(2012) Ming Guo et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Identifying Predictors of Activity Based Anorexia Susceptibility in Diverse Genetic Rodent Populations

(2012) Eneda Pjetri et al.   PLoS One

Neural and hormonal control of food hoarding

(2011) Timothy J. Bartness et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mortality Rates in Patients With Anorexia Nervosa and Other Eating Disorders

(2011) Jon Arcelus   ARCHIVES OF GENERAL PSYCHIATRY

Leptin Does Not Directly Affect CNS Serotonin Neurons to Influence Appetite

(2011) Daniel D. Lam et al.   Cell Metabolism

Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance

(2011) Gina M. Leinninger et al.   Cell Metabolism

Impaired CNS Leptin Action Is Implicated in Depression Associated with Obesity

(2011) Nobuko Yamada et al.   ENDOCRINOLOGY

Leptin deficiency andleptingene mutations in obese children from Pakistan

(2011) Warda Fatima et al.   International Journal of Pediatric Obesity

Screening for anorexia nervosa via measurement of serum leptin levels

(2011) M. Föcker et al.   JOURNAL OF NEURAL TRANSMISSION

Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala

(2011) J Liu et al.   MOLECULAR PSYCHIATRY

Leptin regulates the reward value of nutrient

(2011) Ana I Domingos et al.   NATURE NEUROSCIENCE

Ten years of leptin replacement therapy

(2011) G. Paz-Filho et al.   Obesity Reviews

Food scarcity, neuroadaptations, and the pathogenic potential of dieting in an unnatural ecology: Binge eating and drug abuse

(2011) Kenneth D. Carr   PHYSIOLOGY & BEHAVIOR

Erk1/2 Mediates Leptin Receptor Signaling in the Ventral Tegmental Area

(2011) Richard Trinko et al.   PLoS One

Leptin is an effective treatment for hypothalamic amenorrhea

(2011) S. H. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits

(2010) Jon F. Davis et al.   BIOLOGICAL PSYCHIATRY

Starvation physiology: Reviewing the different strategies animals use to survive a common challenge

(2010) Marshall D. McCue   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Leptin Promotes Gastric Ulcer Healing via Upregulation of Vascular Endothelial Growth Factor

(2010) Tetsuya Tanigawa et al.   DIGESTION

Leptin reduces hyperactivity in an animal model for anorexia nervosa via the ventral tegmental area

(2010) Linda A.W. Verhagen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Critical appraisal of the provisional DSM-5 criteria for anorexia nervosa and an alternative proposal

(2010) Johannes Hebebrand et al.   INTERNATIONAL JOURNAL OF EATING DISORDERS

A New Missense Mutation in the Leptin Gene Causes Mild Obesity and Hypogonadism without Affecting T Cell Responsiveness

(2010) Pamela Fischer-Posovszky et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ventral Tegmental Area Leptin Receptor Neurons Specifically Project to and Regulate Cocaine- and Amphetamine-Regulated Transcript Neurons of the Extended Central Amygdala

(2010) R. L. Leshan et al.   JOURNAL OF NEUROSCIENCE

Direct Innervation and Modulation of Orexin Neurons by Lateral Hypothalamic LepRb Neurons

(2010) G. W. Louis et al.   JOURNAL OF NEUROSCIENCE

Diverse roles of leptin in the gastrointestinal tract: Modulation of motility, absorption, growth, and inflammation

(2010) Shadi S. Yarandi et al.   NUTRITION

Leptin-deficient mice retain normal appetitive spatial learning yet exhibit marked increases in anxiety-related behaviours

(2010) Beate C. Finger et al.   PSYCHOPHARMACOLOGY

Lipodystrophies: Disorders of adipose tissue biology

(2009) Abhimanyu Garg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Geometry of Leptin Action in the Brain: More Complicated Than a Simple ARC

(2009) Martin G. Myers et al.   Cell Metabolism

Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule

(2009) C. Gelegen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Appetite and reward

(2009) Stephanie Fulton   FRONTIERS IN NEUROENDOCRINOLOGY

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient

(2009) I. Mazen et al.   MOLECULAR GENETICS AND METABOLISM

Sex differences in the responses of orexin neurons in the lateral hypothalamic area and feeding behavior to fasting

(2009) Toshiya Funabashi et al.   NEUROSCIENCE LETTERS

Positive Regulatory Control Loop between Gut Leptin and Intestinal GLUT2/GLUT5 Transporters Links to Hepatic Metabolic Functions in Rodents

(2009) Yassine Sakar et al.   PLoS One

Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine

(2009) Jing Liu et al.   PSYCHOPHARMACOLOGY

Stress-induced obesity and the emotional nervous system

(2009) Mary F. Dallman   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice

(2008) A. D. Laposky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Leptin Increases Adult Hippocampal Neurogenesisin Vivoandin Vitro

(2008) Jacob C. Garza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gastroprotective effect of leptin in indomethacin-induced gastric injury

(2008) Tarek K. Motawi et al.   JOURNAL OF BIOMEDICAL SCIENCE

Decreased memory for novel object recognition in chronically food-restricted mice is reversed by acute ghrelin administration

(2008) V.P. Carlini et al.   NEUROSCIENCE