Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe Obesity

Uncovering the molecular mechanisms behind disease-associated leptin variants

(2018) Ellinor Haglund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Adjusting for Tanner Stage Age on Prevalence of Short and Tall Stature of Youths in the United States

(2018) O. Yaw Addo et al.   JOURNAL OF PEDIATRICS

Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes

(2018) Sadia Saeed et al.   Obesity

Severe early onset obesity due to a novel missense mutation in exon 3 of leptin gene in an infant from Northwest India

(2018) Devi Dayal et al.   Journal of Clinical Research in Pediatric Endocrinology

Using high-resolution variant frequencies to empower clinical genome interpretation

(2017) Nicola Whiffin et al.   GENETICS IN MEDICINE

Response to Letter: “Pediatric Obesity—Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline”

(2017) Dennis M. Styne et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Next-generation sequencing of the monogenic obesity genes LEP , LEPR , MC4R , PCSK1 and POMC in a Norwegian cohort of patients with morbid obesity and normal weight controls

(2017) Gry B.N. Nordang et al.   MOLECULAR GENETICS AND METABOLISM

Mini-Review: The Contribution of Intermediate Phenotypes to GxE Effects on Disorders of Body Composition in the New OMICS Era

(2017) Edna Nava-Gonzalez et al.   International Journal of Environmental Research and Public Health

Novel genes involved in severe early-onset obesity revealed by rare copy number and sequence variants

(2017) Clara Serra-Juhé et al.   PLoS Genetics

Genetics of human Bardet-Biedl syndrome, an updates

(2016) S.A. Khan et al.   CLINICAL GENETICS

Rare Genetic Forms of Obesity: Clinical Approach and Current Treatments in 2016

(2016) Hélène Huvenne et al.   Obesity Facts

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

(2015) Sue Richards et al.   GENETICS IN MEDICINE

Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene

(2015) Martin Wabitsch et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A simplified Sanger sequencing method for full genome sequencing of multiple subtypes of human influenza A viruses

(2015) Yi-Mo Deng et al.   JOURNAL OF CLINICAL VIROLOGY

Leptin treatment: Facts and expectations

(2015) Gilberto Paz-Filho et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Genetic variants inLEP,LEPR, andMC4Rexplain 30% of severe obesity in children from a consanguineous population

(2015) Sadia Saeed et al.   Obesity

The Genetics of Pediatric Obesity

(2015) Alessandra Chesi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy

(2015) Cristina Adelia Meehan et al.   Expert Review of Clinical Pharmacology

Genetics and Genomic Medicine in Colombia

(2015) Mauricio De Castro et al.   Molecular Genetics & Genomic Medicine

20 YEARS OF LEPTIN: Leptin at 20: an overview

(2014) Jeffrey Friedman   JOURNAL OF ENDOCRINOLOGY

A Novel Mutation inLeptinGene Is Associated with Severe Obesity in Chinese Individuals

(2014) Yue Zhao et al.   Biomed Research International

A novel mutation of the leptin gene in an Indian patient

(2013) S. Thakur et al.   CLINICAL GENETICS

Idiopathic Hirsutism and Insulin Resistance

(2013) Afsaneh Talaei et al.   International Journal of Endocrinology

Integrating Genomic Analysis with the Genetic Basis of Gene Expression: Preliminary Evidence of the Identification of Causal Genes for Cardiovascular and Metabolic Traits Related to Nutrition in Mexicans

(2012) Raúl A. Bastarrachea et al.   Advances in Nutrition

Leptin in human physiology and pathophysiology

(2011) Christos S. Mantzoros et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leptin deficiency andleptingene mutations in obese children from Pakistan

(2011) Warda Fatima et al.   International Journal of Pediatric Obesity

Evolution of Leptin Structure and Function

(2011) Robert J. Denver et al.   NEUROENDOCRINOLOGY

Ten years of leptin replacement therapy

(2011) G. Paz-Filho et al.   Obesity Reviews

An overview of mongenic and syndromic obesities in humans

(2011) Wendy K. Chung   PEDIATRIC BLOOD & CANCER

Rationale for Leptin-Replacement Therapy for Severe Lipodystrophy

(2010) Elif Oral et al.   Endocrine Practice

From monogenic to polygenic obesity: recent advances

(2010) Anke Hinney et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

A New Missense Mutation in the Leptin Gene Causes Mild Obesity and Hypogonadism without Affecting T Cell Responsiveness

(2010) Pamela Fischer-Posovszky et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

ENU Mutagenesis Identifies Mice with Morbid Obesity and Severe Hyperinsulinemia Caused by a Novel Mutation in Leptin

(2010) Chen-Jee Hong et al.   PLoS One

Human obesity as a heritable disorder of the central control of energy balance

(2009) S O'Rahilly et al.   INTERNATIONAL JOURNAL OF OBESITY

A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient

(2009) I. Mazen et al.   MOLECULAR GENETICS AND METABOLISM

Paleoepidemiology of vertebral degenerative disease in a Pre-Columbian Muisca series from Colombia

(2008) Claudia Rojas-Sepúlveda et al.   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY