Leptin regulates exon-specific transcription of the Bdnf gene via epigenetic modifications mediated by an AKT/p300 HAT cascade

Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

(2020) Michael Notaras et al.   MOLECULAR PSYCHIATRY

SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex

(2019) Yun Lei et al.   MOLECULAR PSYCHIATRY

Role of BDNF in the pathophysiology and treatment of depression: Activity‐dependent effects distinguish rapid‐acting antidepressants

(2019) Ronald S. Duman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Regulation of Hippocampal Synaptic Function by the Metabolic Hormone, Leptin: Implications for Health and Neurodegenerative Disease

(2018) Gemma McGregor et al.   Frontiers in Cellular Neuroscience

Histone methylation and the DNA damage response

(2017) Fade Gong et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

On the Run for Hippocampal Plasticity

(2017) C’iana Cooper et al.   Cold Spring Harbor Perspectives in Medicine

Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal state

(2016) Susan J. Allen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The long road to leptin

(2016) Jeffrey Friedman   JOURNAL OF CLINICAL INVESTIGATION

AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons

(2016) J. Tuvikene et al.   JOURNAL OF NEUROSCIENCE

BDNF – a key transducer of antidepressant effects

(2016) Carl Björkholm et al.   NEUROPHARMACOLOGY

Sex-Specific and Estrous Cycle-Dependent Antidepressant-Like Effects and Hippocampal Akt Signaling of Leptin

(2015) Nicole Carrier et al.   ENDOCRINOLOGY

Leptin/LepRb in the Ventral Tegmental Area Mediates Anxiety-Related Behaviors

(2015) Jing Liu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Functional Role of BDNF Production from Unique Promoters in Aggression and Serotonin Signaling

(2015) Kristen R Maynard et al.   NEUROPSYCHOPHARMACOLOGY

Functional Differentiation of Adult-Born Neurons along the Septotemporal Axis of the Dentate Gyrus: Figure 1.

(2015) Melody V. Wu et al.   Cold Spring Harbor Perspectives in Biology

Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation

(2014) L. Musazzi et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Dentate gyrus-CA3 glutamate release/NMDA transmission mediates behavioral despair and antidepressant-like responses to leptin

(2014) X Wang et al.   MOLECULAR PSYCHIATRY

SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53

(2013) Zhanyun Tang et al.   CELL

Emerging roles for chromatin as a signal integration and storage platform

(2013) Aimee I. Badeaux et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells

(2012) Krishanpal Karmodiya et al.   BMC GENOMICS

Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours

(2012) Ming Guo et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin

(2012) Guey-Ying Liao et al.   NATURE MEDICINE

Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression

(2012) M Guo et al.   Translational Psychiatry

Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex

(2011) Rong-Jian Liu et al.   BIOLOGICAL PSYCHIATRY

Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells

(2011) Christa M. Patterson et al.   BRAIN RESEARCH

Leptin levels are associated with decreased depressive symptoms in women across the weight spectrum, independent of body fat

(2011) Elizabeth A. Lawson et al.   CLINICAL ENDOCRINOLOGY

Impaired CNS Leptin Action Is Implicated in Depression Associated with Obesity

(2011) Nobuko Yamada et al.   ENDOCRINOLOGY

Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling

(2011) J C Garza et al.   MOLECULAR PSYCHIATRY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

High-fat diet selectively protects against the effects of chronic social stress in the mouse

(2011) B.C. Finger et al.   NEUROSCIENCE

A β3-Adrenergic-Leptin-Melanocortin Circuit Regulates Behavioral and Metabolic Changes Induced by Chronic Stress

(2010) Jen-Chieh Chuang et al.   BIOLOGICAL PSYCHIATRY

Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

(2010) Erin M. Bowers et al.   CHEMISTRY & BIOLOGY

Hypothalamic Sites of Leptin Action Linking Metabolism and Reproduction

(2010) José Donato et al.   NEUROENDOCRINOLOGY

Structural Plasticity and Hippocampal Function

(2009) Benedetta Leuner et al.   Annual Review of Psychology

Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding

(2009) Gina M. Leinninger et al.   Cell Metabolism

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine

(2009) Jing Liu et al.   PSYCHOPHARMACOLOGY

Leptin Increases Adult Hippocampal Neurogenesisin Vivoandin Vitro

(2008) Jacob C. Garza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Biological Function for the Neuronal Activity-Dependent Component of Bdnf Transcription in the Development of Cortical Inhibition

(2008) Elizabeth J. Hong et al.   NEURON

Selective Loss of Brain-Derived Neurotrophic Factor in the Dentate Gyrus Attenuates Antidepressant Efficacy

(2007) Megumi Adachi et al.   BIOLOGICAL PSYCHIATRY