Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study

Why clinicians should know about Mendelian randomization

(2021) Sizheng Steven Zhao et al.   RHEUMATOLOGY

Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism

(2021) Jochen Antel et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score

(2020) Qingyuan Zhao et al.   ANNALS OF STATISTICS

Leptin level as a biomarker of uncontrolled eating in obesity and overweight

(2020) Hassiba Benbaibeche et al.   IRISH JOURNAL OF MEDICAL SCIENCE

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

(2020) Hanieh Yaghootkar et al.   DIABETES

Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects

(2020) Gabriella Milos et al.   Translational Psychiatry

Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

(2019) Olof S. Dallner et al.   NATURE MEDICINE

New Insights into the Regulation of Leptin Gene Expression

(2019) Heike Münzberg et al.   Cell Metabolism

Role of Leptin in Mood Disorder and Neurodegenerative Disease

(2019) Xiaohan Zou et al.   Frontiers in Neuroscience

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

(2019) Hunna J. Watson et al.   NATURE GENETICS

Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates

(2019) Jessica M. B. Rees et al.   PLoS One

Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent

(2019) Christopher Hübel et al.   Nature Communications

Mendelian Randomization: Progressing towards understanding causality

(2018) Inke R. König et al.   ANNALS OF NEUROLOGY

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

(2018) James J. Lee et al.   NATURE GENETICS

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants

(2017) Stephen Burgess et al.   EPIDEMIOLOGY

Interpreting findings from Mendelian randomization using the MR-Egger method

(2017) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

(2017) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Interactions between metabolic, reward and cognitive processes in appetite control: Implications for novel weight management therapies

(2017) Suzanne Higgs et al.   JOURNAL OF PSYCHOPHARMACOLOGY

A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

(2017) Dong Li et al.   Scientific Reports

Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

(2016) Philip C Haycock et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Bias due to participant overlap in two-sample Mendelian randomization

(2016) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique

(2016) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Selecting instruments for Mendelian randomization in the wake of genome-wide association studies

(2016) Daniel I Swerdlow et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

(2016) Tuomas O. Kilpeläinen et al.   Nature Communications

Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons

(2015) Maria Fernanda A. Fernandes et al.   Cell Metabolism

Exercise Addiction in Men Is Associated With Lower Fat-Adjusted Leptin Levels

(2015) Mia B. Lichtenstein et al.   CLINICAL JOURNAL OF SPORT MEDICINE

Time trends in lifetime incidence rates of first-time diagnosed anorexia nervosa and bulimia nervosa across 16 years in a danish nationwide psychiatric registry study

(2015) Hans-Christoph Steinhausen et al.   INTERNATIONAL JOURNAL OF EATING DISORDERS

Mendelian randomization: where are we now and where are we going?

(2015) S. Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

A review of instrumental variable estimators for Mendelian randomization

(2015) Stephen Burgess et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Genes and the hypothalamic control of metabolism in humans

(2014) Anke Hinney et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

SNiPA: an interactive, genetic variant-centered annotation browser

(2014) Matthias Arnold et al.   BIOINFORMATICS

20 YEARS OF LEPTIN: Insights into signaling assemblies of the leptin receptor

(2014) Frank Peelman et al.   JOURNAL OF ENDOCRINOLOGY

Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome

(2014) Emma Raitoharju et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

“Eating addiction”, rather than “food addiction”, better captures addictive-like eating behavior

(2014) Johannes Hebebrand et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Endocrine consequences of anorexia nervosa

(2014) Madhusmita Misra et al.   Lancet Diabetes & Endocrinology

Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators

(2013) B. L. Pierce et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Genome-wide association study identifies three novel loci for type 2 diabetes

(2013) Kazuo Hara et al.   HUMAN MOLECULAR GENETICS

Calculating statistical power in Mendelian randomization studies

(2013) Marie-Jo A Brion et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Serum leptin and loss of control eating in children and adolescents

(2013) R Miller et al.   INTERNATIONAL JOURNAL OF OBESITY

Leptin in human physiology and pathophysiology

(2011) Christos S. Mantzoros et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Childhood eating disorders: British national surveillance study

(2011) Dasha E. Nicholls et al.   BRITISH JOURNAL OF PSYCHIATRY

Metabolic and hedonic drives in the neural control of appetite: who is the boss?

(2011) Hans-Rudolf Berthoud   CURRENT OPINION IN NEUROBIOLOGY

Endocrine Dysregulation in Anorexia Nervosa Update

(2011) K. K. Miller   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hedonic and incentive signals for body weight control

(2011) Emil Egecioglu et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Critical appraisal of the provisional DSM-5 criteria for anorexia nervosa and an alternative proposal

(2010) Johannes Hebebrand et al.   INTERNATIONAL JOURNAL OF EATING DISORDERS

Reward, dopamine and the control of food intake: implications for obesity

(2010) Nora D. Volkow et al.   TRENDS IN COGNITIVE SCIENCES

Leptin signaling in brain: A link between nutrition and cognition?

(2008) Christopher D. Morrison   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Identification of miRNAs associated with tumorigenesis of retinoblastoma by miRNA microarray analysis

(2008) Jian-Jun Zhao et al.   CHILDS NERVOUS SYSTEM

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE