Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency

Response to Letter: “Pediatric Obesity—Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline”

(2017) Dennis M. Styne et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Limitations of Transforming Very High Body Mass Indexes into z -Scores among 8.7 Million 2- to 4-Year-Old Children

(2017) David S. Freedman et al.   JOURNAL OF PEDIATRICS

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults

(2017) Leandra Abarca-Gómez et al.   LANCET

BMI z -Scores are a poor indicator of adiposity among 2- to 19-year-olds with very high BMIs, NHANES 1999-2000 to 2013-2014

(2017) David S. Freedman et al.   Obesity

Measurement of immunofunctional leptin to detect and monitor patients with functional leptin deficiency

(2016) Martin Wabitsch et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Prevalence and phenotypic characterization of MC4R variants in a large pediatric cohort

(2016) H Vollbach et al.   INTERNATIONAL JOURNAL OF OBESITY

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

(2016) Peter Kühnen et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Hunger Genes: Pathways to Obesity

(2015) Agatha A. van der Klaauw et al.   CELL

Monogene und syndromale Krankheitsbilder bei morbider Adipositas

(2015) S. Wiegand et al.   INTERNIST

Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene

(2015) Martin Wabitsch et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Seven Novel DeleteriousLEPRMutations Found in Early-Onset Obesity: a ΔExon6–8 Shared by Subjects From Reunion Island, France, Suggests a Founder Effect

(2015) Hélène Huvenne et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Biologically Inactive Leptin and Early-Onset Extreme Obesity

(2015) Martin Wabitsch et al.   NEW ENGLAND JOURNAL OF MEDICINE

20 YEARS OF LEPTIN: Human disorders of leptin action

(2014) I Sadaf Farooqi et al.   JOURNAL OF ENDOCRINOLOGY

Functional characterization of a new human melanocortin-4 receptor homozygous mutation (N72K) that is associated with early-onset obesity

(2014) Patric J. D. Delhanty et al.   MOLECULAR BIOLOGY REPORTS

Neue Perzentilwerte für die Körpermaße neugeborener Einlinge: Ergebnisse der deutschen Perinatalerhebung der Jahre 2007–2011 unter Beteiligung aller 16 Bundesländer

(2014) M. Voigt et al.   ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE

Leptin Substitution Results in the Induction of Menstrual Cycles in an Adolescent with Leptin Deficiency and Hypogonadotropic Hypogonadism

(2012) J. von Schnurbein et al.   Hormone Research in Paediatrics

Homozygosity for two missense mutations in the leptin receptor gene (P316T;W646C) in a Turkmenian girl with severe early-onset obesity

(2011) Nesibe Andiran et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Pharmacological Characterization of 30 Human Melanocortin-4 Receptor Polymorphisms with the Endogenous Proopiomelanocortin-Derived Agonists, Synthetic Agonists, and the Endogenous Agouti-Related Protein Antagonist,‡

(2010) Zhimin Xiang et al.   BIOCHEMISTRY

Melanocortin-4 Receptor Polymorphisms in Turkish Pediatric Obese Patients

(2010) Duygu Ozel Demiralp et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

A New Missense Mutation in the Leptin Gene Causes Mild Obesity and Hypogonadism without Affecting T Cell Responsiveness

(2010) Pamela Fischer-Posovszky et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient

(2009) I. Mazen et al.   MOLECULAR GENETICS AND METABOLISM

The Stigma of Obesity: A Review and Update

(2009) Rebecca M. Puhl et al.   Obesity

Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees

(2008) F. Stutzmann et al.   DIABETES

Perceptions of weight discrimination: prevalence and comparison to race and gender discrimination in America

(2008) R M Puhl et al.   INTERNATIONAL JOURNAL OF OBESITY