Neural substrates of appetitive and aversive prediction error

Targeted Stimulation of Human Orbitofrontal Networks Disrupts Outcome-Guided Behavior

(2020) James D. Howard et al.   CURRENT BIOLOGY

Causal evidence supporting the proposal that dopamine transients function as temporal difference prediction errors

(2020) Etienne J. P Maes et al.   NATURE NEUROSCIENCE

Amygdala Reward Neurons Form and Store Fear Extinction Memory

(2020) Xiangyu Zhang et al.   NEURON

Dopamine transients do not act as model-free prediction errors during associative learning

(2020) Melissa J. Sharpe et al.   Nature Communications

A VTA to Basal Amygdala Dopamine Projection Contributes to Signal Salient Somatosensory Events during Fear Learning

(2020) Wei Tang et al.   JOURNAL OF NEUROSCIENCE

Molecular and anatomical organization of the dorsal raphe nucleus

(2019) Kee Wui Huang et al.   eLife

Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture

(2019) Dan J. Chandler et al.   JOURNAL OF NEUROSCIENCE

Adaptive disinhibitory gating by VIP interneurons permits associative learning

(2019) Sabine Krabbe et al.   NATURE NEUROSCIENCE

Early adolescent adversity inflates threat estimation in females and promotes alcohol use initiation in both sexes.

(2018) Rachel A. Walker et al.   BEHAVIORAL NEUROSCIENCE

Pain-Related Expectation and Prediction Error Signals in the Anterior Insula Are Not Related to Aversiveness

(2018) Sepideh Fazeli et al.   JOURNAL OF NEUROSCIENCE

A dopaminergic switch for fear to safety transitions

(2018) Ray Luo et al.   Nature Communications

Noradrenergic Modulation of Fear Conditioning and Extinction

(2018) Thomas F. Giustino et al.   Frontiers in Behavioral Neuroscience

Brief, but not prolonged, pauses in the firing of midbrain dopamine neurons are sufficient to produce a conditioned inhibitor

(2018) Chun Yun Chang et al.   JOURNAL OF NEUROSCIENCE

Dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli

(2018) William Menegas et al.   NATURE NEUROSCIENCE

Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes

(2018) Ximena I Salinas-Hernández et al.   eLife

Basolateral Amygdala Neurons Maintain Aversive Emotional Salience

(2017) Auntora Sengupta et al.   JOURNAL OF NEUROSCIENCE

Neural ensemble dynamics underlying a long-term associative memory

(2017) Benjamin F. Grewe et al.   NATURE

Modular organization of the brainstem noradrenaline system coordinates opposing learning states

(2017) Akira Uematsu et al.   NATURE NEUROSCIENCE

Dopamine transients are sufficient and necessary for acquisition of model-based associations

(2017) Melissa J Sharpe et al.   NATURE NEUROSCIENCE

Effects of chemogenetic excitation or inhibition of the ventrolateral periaqueductal gray on the acquisition and extinction of Pavlovian fear conditioning

(2017) Carolyn Arico et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Dopamine Neurons Respond to Errors in the Prediction of Sensory Features of Expected Rewards

(2017) Yuji K. Takahashi et al.   NEURON

Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior

(2017) Jordan G McCall et al.   eLife

Ventral striatal lesions disrupt dopamine neuron signaling of differences in cue value caused by changes in reward timing but not number.

(2016) Yuji K. Takahashi et al.   BEHAVIORAL NEUROSCIENCE

Disrupted Prediction Error Links Excessive Amygdala Activation to Excessive Fear

(2016) A. Sengupta et al.   JOURNAL OF NEUROSCIENCE

Antagonistic negative and positive neurons of the basolateral amygdala

(2016) Joshua Kim et al.   NATURE NEUROSCIENCE

Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target

(2016) Nathan F Parker et al.   NATURE NEUROSCIENCE

Temporal Specificity of Reward Prediction Errors Signaled by Putative Dopamine Neurons in Rat VTA Depends on Ventral Striatum

(2016) Yuji K. Takahashi et al.   NEURON

Adaptive Prediction Error Coding in the Human Midbrain and Striatum Facilitates Behavioral Adaptation and Learning Efficiency

(2016) Kelly M.J. Diederen et al.   NEURON

Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation

(2016) Edward H. Nieh et al.   NEURON

Extinction of alcohol seeking is enhanced by compound extinction and the noradrenaline reuptake inhibitor atomoxetine

(2015) Hiu T. Leung et al.   ADDICTION BIOLOGY

Neural Representations of Unconditioned Stimuli in Basolateral Amygdala Mediate Innate and Learned Responses

(2015) Felicity Gore et al.   CELL

Pharmacogenetic Excitation of Dorsomedial Prefrontal Cortex Restores Fear Prediction Error

(2015) J. O.-Y. Yau et al.   JOURNAL OF NEUROSCIENCE

Compound stimulus extinction reduces spontaneous recovery in humans

(2015) C. A. O. Coelho et al.   LEARNING & MEMORY

Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies

(2015) M A Fullana et al.   MOLECULAR PSYCHIATRY

A circuit mechanism for differentiating positive and negative associations

(2015) Praneeth Namburi et al.   NATURE

From circuits to behaviour in the amygdala

(2015) Patricia H. Janak et al.   NATURE

Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors

(2015) Chun Yun Chang et al.   NATURE NEUROSCIENCE

The effects of compound stimulus extinction and inhibition of noradrenaline reuptake on the renewal of alcohol seeking

(2015) T M Furlong et al.   Translational Psychiatry

The dorsal raphe nucleus is integral to negative prediction errors in Pavlovian fear

(2014) Benjamin A. Berg et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Aversive Prediction Error Signals in the Amygdala

(2014) S. B. McHugh et al.   JOURNAL OF NEUROSCIENCE

Phasic Dopamine Release in the Rat Nucleus Accumbens Symmetrically Encodes a Reward Prediction Error Term

(2014) Andrew S. Hart et al.   JOURNAL OF NEUROSCIENCE

Amygdala interneuron subtypes control fear learning through disinhibition

(2014) Steffen B. E. Wolff et al.   NATURE

Representation of aversive prediction errors in the human periaqueductal gray

(2014) Mathieu Roy et al.   NATURE NEUROSCIENCE

Amygdala Microcircuits Controlling Learned Fear

(2014) Sevil Duvarci et al.   NEURON

Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation

(2014) Joshua P. Johansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

If it bleeds, it leads: separating threat from mere negativity

(2014) Kestutis Kveraga et al.   Social Cognitive and Affective Neuroscience

Mediofrontal negativity signals unexpected omission of aversive events

(2014) Sara Garofalo et al.   Scientific Reports

Thy1-Expressing Neurons in the Basolateral Amygdala May Mediate Fear Inhibition

(2013) A. M. Jasnow et al.   JOURNAL OF NEUROSCIENCE

Safety Encoding in the Basal Amygdala

(2013) S. Sangha et al.   JOURNAL OF NEUROSCIENCE

A causal link between prediction errors, dopamine neurons and learning

(2013) Elizabeth E Steinberg et al.   NATURE NEUROSCIENCE

Functional Connectivity between Amygdala and Cingulate Cortex for Adaptive Aversive Learning

(2013) Oded Klavir et al.   NEURON

Opposing Catecholamine Changes in the Bed Nucleus of the Stria Terminalis During Intracranial Self-Stimulation and Its Extinction

(2012) Jinwoo Park et al.   BIOLOGICAL PSYCHIATRY

Activation of the ventral striatum during aversive contextual conditioning in humans

(2012) Sebastian T. Pohlack et al.   BIOLOGICAL PSYCHOLOGY

Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors

(2012) Edward H. Nieh et al.   BRAIN RESEARCH

Deepened extinction of cocaine cues

(2012) David N. Kearns et al.   DRUG AND ALCOHOL DEPENDENCE

Surprise! Neural correlates of Pearce-Hall and Rescorla-Wagner coexist within the brain

(2012) Matthew R. Roesch et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neurobiological Mechanisms Underlying the Blocking Effect in Aversive Learning

(2012) F. Eippert et al.   JOURNAL OF NEUROSCIENCE

Subsecond Dopamine Release in the Nucleus Accumbens Predicts Conditioned Punishment and Its Successful Avoidance

(2012) E. B. Oleson et al.   JOURNAL OF NEUROSCIENCE

Braking Dopamine Systems: A New GABA Master Structure for Mesolimbic and Nigrostriatal Functions

(2012) M. Barrot et al.   JOURNAL OF NEUROSCIENCE

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

(2012) Jeremiah Y. Cohen et al.   NATURE

Input-specific control of reward and aversion in the ventral tegmental area

(2012) Stephan Lammel et al.   NATURE

Brain activity associated with omission of an aversive event reveals the effects of fear learning and generalization

(2012) Joseph E. Dunsmoor et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Activation of VTA GABA Neurons Disrupts Reward Consumption

(2012) Ruud van Zessen et al.   NEURON

GABA Neurons of the VTA Drive Conditioned Place Aversion

(2012) Kelly R. Tan et al.   NEURON

A new control center for dopaminergic systems: pulling the VTA by the tail

(2012) Romain Bourdy et al.   TRENDS IN NEUROSCIENCES

Hippocampal regulation of aversive memories

(2011) Ki Ann Goosens   CURRENT OPINION IN NEUROBIOLOGY

Opioid-Sensitive GABA Inputs from Rostromedial Tegmental Nucleus Synapse onto Midbrain Dopamine Neurons

(2011) A. Matsui et al.   JOURNAL OF NEUROSCIENCE

Negative Reward Signals from the Lateral Habenula to Dopamine Neurons Are Mediated by Rostromedial Tegmental Nucleus in Primates

(2011) S. Hong et al.   JOURNAL OF NEUROSCIENCE

Ventral Striatum and Orbitofrontal Cortex Are Both Required for Model-Based, But Not Model-Free, Reinforcement Learning

(2011) M. A. McDannald et al.   JOURNAL OF NEUROSCIENCE

Differential roles of human striatum and amygdala in associative learning

(2011) Jian Li et al.   NATURE NEUROSCIENCE

Expectancy-related changes in firing of dopamine neurons depend on orbitofrontal cortex

(2011) Yuji K Takahashi et al.   NATURE NEUROSCIENCE

Projection-Specific Modulation of Dopamine Neuron Synapses by Aversive and Rewarding Stimuli

(2011) Stephan Lammel et al.   NEURON

Compound Stimulus Presentation and the Norepinephrine Reuptake Inhibitor Atomoxetine Enhance Long-Term Extinction of Cocaine-Seeking Behavior

(2011) Patricia H Janak et al.   NEUROPSYCHOPHARMACOLOGY

Inhibitory Inputs from Rostromedial Tegmental Neurons Regulate Spontaneous Activity of Midbrain Dopamine Cells and Their Responses to Drugs of Abuse

(2011) Salvatore Lecca et al.   NEUROPSYCHOPHARMACOLOGY

Neuronal circuits underlying acute morphine action on dopamine neurons

(2011) M. Jalabert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Specificity of Multiple Hippocampal Processes Governing Fear Extinction

(2011) Jelena Radulovic et al.   REVIEWS IN THE NEUROSCIENCES

Placing prediction into the fear circuit

(2011) Gavan P. McNally et al.   TRENDS IN NEUROSCIENCES

Dopamine transmission in the amygdala modulates surprise in an aversive blocking paradigm.

(2010) Mihaela D. Iordanova   BEHAVIORAL NEUROSCIENCE

The inhibitory influence of the lateral habenula on midbrain dopamine cells: Ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental nucleus

(2010) Judith Joyce Balcita-Pedicino et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Neural Correlates of Variations in Event Processing during Learning in Basolateral Amygdala

(2010) M. R. Roesch et al.   JOURNAL OF NEUROSCIENCE

Deepened extinction following compound stimulus presentation: Noradrenergic modulation

(2010) P. H. Janak et al.   LEARNING & MEMORY

Neural substrates for expectation-modulated fear learning in the amygdala and periaqueductal gray

(2010) Joshua P Johansen et al.   NATURE NEUROSCIENCE

The neural correlates of negative prediction error signaling in human fear conditioning

(2010) V.I. Spoormaker et al.   NEUROIMAGE

Effects of Drugs of Abuse on Putative Rostromedial Tegmental Neurons, Inhibitory Afferents to Midbrain Dopamine Cells

(2010) Salvatore Lecca et al.   NEUROPSYCHOPHARMACOLOGY

Optical activation of lateral amygdala pyramidal cells instructs associative fear learning

(2010) Joshua P. Johansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural activity associated with monitoring the oscillating threat value of a tarantula

(2010) D. Mobbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta

(2009) Thomas C. Jhou et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Segregated Populations of Hippocampal Principal CA1 Neurons Mediating Conditioning and Extinction of Contextual Fear

(2009) N. C. Tronson et al.   JOURNAL OF NEUROSCIENCE

Complementary roles for amygdala and periaqueductal gray in temporal-difference fear learning

(2009) S. Cole et al.   LEARNING & MEMORY

Hippocampal Erk mechanisms linking prediction error to fear extinction: Roles of shock expectancy and contextual aversive valence

(2009) K. H. Huh et al.   LEARNING & MEMORY

Two types of dopamine neuron distinctly convey positive and negative motivational signals

(2009) Masayuki Matsumoto et al.   NATURE

The locus coeruleus and noradrenergic modulation of cognition

(2009) Susan J. Sara   NATURE REVIEWS NEUROSCIENCE

Stress signalling pathways that impair prefrontal cortex structure and function

(2009) Amy F. T. Arnsten   NATURE REVIEWS NEUROSCIENCE

The Rostromedial Tegmental Nucleus (RMTg), a GABAergic Afferent to Midbrain Dopamine Neurons, Encodes Aversive Stimuli and Inhibits Motor Responses

(2009) Thomas C. Jhou et al.   NEURON

The effects of yohimbine and amphetamine on fear expression and extinction in rats

(2009) Devin Mueller et al.   PSYCHOPHARMACOLOGY

Ultrastructural analysis of local collaterals of rat ventral tegmental area neurons: GABA phenotype and synapses onto dopamine and GABA cells

(2009) Natalia Omelchenko et al.   SYNAPSE

Noradrenergic Signaling in Infralimbic Cortex Increases Cell Excitability and Strengthens Memory for Fear Extinction

(2008) D. Mueller et al.   JOURNAL OF NEUROSCIENCE

From Fear to Safety and Back: Reversal of Fear in the Human Brain

(2008) D. Schiller et al.   JOURNAL OF NEUROSCIENCE

Switching on and off fear by distinct neuronal circuits

(2008) Cyril Herry et al.   NATURE

Representation of negative motivational value in the primate lateral habenula

(2008) Masayuki Matsumoto et al.   NATURE NEUROSCIENCE

Neural correlates of unconditioned response diminution during Pavlovian conditioning

(2008) Joseph E. Dunsmoor et al.   NEUROIMAGE

The role of the striatum in aversive learning and aversive prediction errors

(2008) M. R Delgado et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

BOLD Responses Reflecting Dopaminergic Signals in the Human Ventral Tegmental Area

(2008) K. D'Ardenne et al.   SCIENCE