New Molecular Targets for Antidepressant Drugs

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

(2021) Plinio C. Casarotto et al.   CELL

Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

(2021) Silvia Vaena et al.   Cell Reports

Serum ceramide concentrations are associated with depression in patients after ischemic stroke-A two-center case-controlled study

(2021) Lv Hong et al.   CLINICA CHIMICA ACTA

Association between serum sphingolipids and eudaimonic well-being in white U.S. adults

(2021) Loni Berkowitz et al.   Scientific Reports

Effect of Zuranolone vs Placebo in Postpartum Depression

(2021) Kristina M. Deligiannidis et al.   JAMA Psychiatry

Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity

(2020) Kan Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sex differences in autophagy-mediated diseases: toward precision medicine

(2020) Dangtong Shang et al.   Autophagy

Effect of antidepressant drugs on the brain sphingolipid system

(2020) Estabraq Jaddoa et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The Role of BDNF on Neural Plasticity in Depression

(2020) Tao Yang et al.   Frontiers in Cellular Neuroscience

The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice

(2020) Iulia Zoicas et al.   Cells

Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies

(2020) Diana Zukas Andreotti et al.   Frontiers in Nutrition

Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems

(2020) Stefanie Zeitler et al.   Cells

New agents and perspectives in the pharmacological treatment of major depressive disorder

(2020) Marsal Sanches et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders

(2019) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

Influence of Normal Aging on Brain Autophagy: A Complex Scenario

(2019) David A. Loeffler   Frontiers in Aging Neuroscience

Comparative efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults: systematic review and network meta-analysis

(2019) Julian Mutz et al.   BMJ-British Medical Journal

The effects of dietary improvement on symptoms of depression and anxiety

(2019) Joseph Firth et al.   PSYCHOSOMATIC MEDICINE

Is There a Role of Autophagy in Depression and Antidepressant Action?

(2019) Nils C. Gassen et al.   Frontiers in Psychiatry

Neurogenesis and antidepressant action

(2019) Seon-Cheol Park   CELL AND TISSUE RESEARCH

Acid Sphingomyelinase – a Regulator of TRPC 6 Channel Activity

(2019) Stefanie Zeitler et al.   JOURNAL OF NEUROCHEMISTRY

Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder

(2019) Nathalie Brunkhorst-Kanaan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Secretory Acid Sphingomyelinase in the Serum of Medicated Patients Predicts the Prospective Course of Depression

(2019) Christiane Mühle et al.   Journal of Clinical Medicine

Changes in the global burden of depression from 1990 to 2017: Findings from the Global Burden of Disease study

(2019) Qingqing Liu et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Trial of SAGE-217 in Patients with Major Depressive Disorder

(2019) Handan Gunduz-Bruce et al.   NEW ENGLAND JOURNAL OF MEDICINE

Brexanolone for postpartum depression: A meta-analysis of randomized controlled studies

(2019) Wei Zheng et al.   PSYCHIATRY RESEARCH

BDNF‐TrkB pathway mediates antidepressant‐like roles of H 2 S in diabetic rats via promoting hippocampal autophagy

(2019) Hai‐Yao Liu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model

(2019) Rebecca B. Price et al.   MOLECULAR PSYCHIATRY

Effects of n-3PUFAs on autophagy and inflammation of hypothalamus and body weight in mice

(2018) Xin Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy in health and disease: A comprehensive review

(2018) Sarbari Saha et al.   BIOMEDICINE & PHARMACOTHERAPY

The antidepressant effects of ɑ-tocopherol are related to activation of autophagy via the AMPK/mTOR pathway

(2018) Xiaoyan Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

(2018) Andrea Cipriani et al.   LANCET

Defective Autophagy in Atherosclerosis: To Die or to Senesce?

(2018) Mandy O. J. Grootaert et al.   Oxidative Medicine and Cellular Longevity

Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect

(2018) Dolores Corella et al.   Annual Review of Food Science and Technology

Association of Efficacy of Resistance Exercise Training With Depressive Symptoms

(2018) Brett R. Gordon et al.   JAMA Psychiatry

The effect of fasting or calorie restriction on autophagy induction: A review of the literature

(2018) Mohammad Bagherniya et al.   AGEING RESEARCH REVIEWS

Ketamine induces reactive oxygen species and enhances autophagy in SV-HUC-1 human uroepithelial cells

(2018) Zhengfei Shan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Discovery of 4-Benzyloxybenzo[d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/db Mice

(2018) Mingguang Mo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Derivatization of common antidepressant drugs increases inhibition of acid sphingomyelinase and reduces induction of phospholipidosis

(2018) Cosima Rhein et al.   JOURNAL OF NEURAL TRANSMISSION

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

(2018) Anne Gulbins et al.   MOLECULAR PSYCHIATRY

Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies

(2018) Camille Lassale et al.   MOLECULAR PSYCHIATRY

The effect of a very low calorie diet on subjective depressive symptoms and anxiety: meta-analysis and systematic review

(2018) Natalie Ein et al.   INTERNATIONAL JOURNAL OF OBESITY

Depression

(2018) Gin S Malhi et al.   LANCET

On the Role of Basal Autophagy in Adult Neural Stem Cells and Neurogenesis

(2018) Lucía Casares-Crespo et al.   Frontiers in Cellular Neuroscience

Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation

(2018) Martin Reichel et al.   Frontiers in Psychiatry

Adherence to the Mediterranean diet and risk of depression: a systematic review and updated meta-analysis of observational studies

(2018) Fateme Shafiei et al.   NUTRITION REVIEWS

Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor

(2018) Yali Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors

(2017) Ryutaro Adachi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis

(2017) Tadahiro Numakawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis

(2017) Qin Xiang Ng et al.   JOURNAL OF AFFECTIVE DISORDERS

Ceramides and depression: A systematic review

(2017) Adam Dinoff et al.   JOURNAL OF AFFECTIVE DISORDERS

The mechanism of acute fasting-induced antidepressant-like effects in mice

(2017) Ranji Cui et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Rapid Response to Electroconvulsive Therapy

(2017) Duy V. Tran et al.   JOURNAL OF ECT

Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial

(2017) Stephen Kanes et al.   LANCET

Plasma sphingolipids and depressive symptoms in coronary artery disease

(2017) Adam Dinoff et al.   Brain and Behavior

Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis

(2017) Zhan Zhao et al.   Frontiers in Molecular Neuroscience

miR-16 and Fluoxetine Both Reverse Autophagic and Apoptotic Change in Chronic Unpredictable Mild Stress Model Rats

(2017) Yang Yang et al.   Frontiers in Neuroscience

Initial depression severity and response to antidepressants v. placebo: patient-level data analysis from 34 randomised controlled trials

(2016) Jonathan Rabinowitz et al.   BRITISH JOURNAL OF PSYCHIATRY

Circadian rhythm of autophagy proteins in hippocampus is blunted by sleep fragmentation

(2016) Yi He et al.   CHRONOBIOLOGY INTERNATIONAL

Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis

(2016) Zi-Jian Xiong et al.   JOURNAL OF MOLECULAR BIOLOGY

Exercise as a treatment for depression: A meta-analysis adjusting for publication bias

(2016) Felipe B. Schuch et al.   JOURNAL OF PSYCHIATRIC RESEARCH

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Human acid sphingomyelinase structures provide insight to molecular basis of Niemann–Pick disease

(2016) Yan-Feng Zhou et al.   Nature Communications

Crystal structure of mammalian acid sphingomyelinase

(2016) Alexei Gorelik et al.   Nature Communications

Propofol Mitigates Learning and Memory Impairment After Electroconvulsive Shock in Depressed Rats by Inhibiting Autophagy in the Hippocampus

(2016) Ping Li et al.   MEDICAL SCIENCE MONITOR

Major depressive disorder

(2016) Christian Otte et al.   Nature Reviews Disease Primers

Autophagy inhibitors

(2015) Benoit Pasquier   CELLULAR AND MOLECULAR LIFE SCIENCES

Is depression associated with increased oxidative stress? A systematic review and meta-analysis

(2015) Catherine N. Black et al.   PSYCHONEUROENDOCRINOLOGY

Acid Sphingomyelinase Amplifies Redox Signaling in Pseudomonas aeruginosa-Induced Macrophage Apoptosis

(2014) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

(2014) Nils C. Gassen et al.   PLOS MEDICINE

Human umbilical endothelial cells (HUVECs) have a sex: characterisation of the phenotype of male and female cells

(2014) Roberta Addis et al.   Biology of Sex Differences

Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile

(2013) Brenda WJH Penninx et al.   BMC Medicine

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

(2013) Lutz Nährlich et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling

(2013) Jeanine H. Heiser et al.   JOURNAL OF NEUROCHEMISTRY

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

(2013) Erich Gulbins et al.   NATURE MEDICINE

Physical exercise intervention in depressive disorders: Meta-analysis and systematic review

(2013) T. Josefsson et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Exercise induces autophagy in peripheral tissues and in the brain

(2012) Congcong He et al.   Autophagy

Age and risk for depression among the elderly: a meta-analysis of the published literature

(2012) Ke-Xiang Zhao et al.   CNS SPECTRUMS

Cognitive, Psychological and Psychiatric Effects of Ionizing Radiation Exposure

(2012) D. Marazziti et al.   CURRENT MEDICINAL CHEMISTRY

The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase-Dependent and -Independent Cell Death in T Lymphocytes

(2012) Delphine Milhas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

(2012) F.-Xabier Contreras et al.   NATURE

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Tricyclodecan-9-yl-Xanthogenate (D609) Mechanism of Actions: A Mini-Review of Literature

(2011) Rao Muralikrishna Adibhatla et al.   NEUROCHEMICAL RESEARCH

Antidepressant Drugs Diversely Affect Autophagy Pathways in Astrocytes and Neurons—Dissociation from Cholesterol Homeostasis

(2011) Jürgen Zschocke et al.   NEUROPSYCHOPHARMACOLOGY

Identification of Novel Functional Inhibitors of Acid Sphingomyelinase

(2011) Johannes Kornhuber et al.   PLoS One

Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications

(2010) Johannes Kornhuber et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Antidepressant Drug Effects and Depression Severity

(2010) Jay C. Fournier et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Therapeutic Efficacy and Safety of Amitriptyline in Patients with Cystic Fibrosis

(2009) Joachim Riethmüller et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The role of ceramide in major depressive disorder

(2009) Johannes Kornhuber et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Autophagy regulates adipose mass and differentiation in mice

(2009) Rajat Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

(2009) Andreas Heiseke et al.   JOURNAL OF NEUROCHEMISTRY

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

(2009) Denis J. David et al.   NEURON

Quantitative modeling of selective lysosomal targeting for drug design

(2008) Stefan Trapp et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model

(2007) Johannes Kornhuber et al.   JOURNAL OF MEDICINAL CHEMISTRY