A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images

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Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

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Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

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Signaling in the primary cilium through the lens of the Hedgehog pathway

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Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium

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Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling

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Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

(2020) Cristina Olivieri et al.   eLife

Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

(2020) Xiaofeng Qi et al.   Nature Chemical Biology

Biochemical mechanisms of vertebrate hedgehog signaling

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Establishing and regulating the composition of cilia for signal transduction

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Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

(2019) Ishan Deshpande et al.   NATURE

Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP

(2019) Tsan-Wen Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity

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Structural Basis of Smoothened Activation in Hedgehog Signaling

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Atrioventricular canal defect and genetic syndromes: The unifying role of sonic hedgehog

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Wnt signaling in development and tissue homeostasis

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Unexplored therapeutic opportunities in the human genome

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G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog

(2018) Ganesh V. Pusapati et al.   Science Signaling

Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

(2018) Issei S. Shimada et al.   Cell Reports

Cytosolic proteins can exploit membrane localization to trigger functional assembly

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G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog

(2018) Ganesh V. Pusapati et al.   Science Signaling

The Molecular Basis for Specificity at the Level of the Protein Kinase a Catalytic Subunit

(2018) Kristoffer Søberg et al.   Frontiers in Endocrinology

Divalent metal ions control activity and inhibition of protein kinases

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Trends in GPCR drug discovery: new agents, targets and indications

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Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and cross-linking approaches

(2017) Ryan Walker-Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium

(2017) Benjamin R. Myers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local protein kinase A action proceeds through intact holoenzymes

(2017) F. Donelson Smith et al.   SCIENCE

Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

(2016) Ekaterina Pak et al.   DEVELOPMENTAL CELL

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened

(2016) Zhonghua Zhao et al.   EMBO REPORTS

Smoothened determines β-arrestin–mediated removal of the G protein–coupled receptor Gpr161 from the primary cilium

(2016) Kasturi Pal et al.   JOURNAL OF CELL BIOLOGY

Structural basis of Smoothened regulation by its extracellular domains

(2016) Eamon F. X. Byrne et al.   NATURE

Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics

(2016) Bryn S. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bimodal antagonism of PKA signalling by ARHGAP36

(2016) Rebecca L. Eccles et al.   Nature Communications

NanoBRET—A Novel BRET Platform for the Analysis of Protein–Protein Interactions

(2015) Thomas Machleidt et al.   ACS Chemical Biology

Divalent Metal Ions Mg2+ and Ca2+ Have Distinct Effects on Protein Kinase A Activity and Regulation

(2015) Matthias J. Knape et al.   ACS Chemical Biology

Proteomics of Primary Cilia by Proximity Labeling

(2015) David U. Mick et al.   DEVELOPMENTAL CELL

Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation

(2015) Jonggul Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of ciliary trafficking in Hedgehog receptor signaling

(2015) Jynho Kim et al.   Science Signaling

The role of ciliary trafficking in Hedgehog receptor signaling

(2015) Jynho Kim et al.   Science Signaling

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

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Identification of recurrent SMO and BRAF mutations in ameloblastomas

(2014) Robert T Sweeney et al.   NATURE GENETICS

Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

(2014) Pawel Niewiadomski et al.   Cell Reports

Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

(2014) Jennifer L Stamos et al.   eLife

PKA: Lessons learned after twenty years

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The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

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Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response

(2013) Benjamin R. Myers et al.   DEVELOPMENTAL CELL

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification

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The mechanisms of Hedgehog signalling and its roles in development and disease

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Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Assembly of allosteric macromolecular switches: lessons from PKA

(2012) Susan S. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human limb abnormalities caused by disruption of hedgehog signaling

(2012) Eve Anderson et al.   TRENDS IN GENETICS

Gli Proteins in Development and Disease

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Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube

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Inhibition of GSK3 by Wnt signalling - two contrasting models

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Mechanisms and functions of Hedgehog signalling across the metazoa

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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

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Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6

(2009) Geng Wu et al.   PLoS One

Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium

(2009) Christopher W. Wilson et al.   PLoS One

Primary Cilia Are Not Required for Normal Canonical Wnt Signaling in the Mouse Embryo

(2009) Polloneal Jymmiel R. Ocbina et al.   PLoS One

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

(2009) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA

(2008) Bastian Zimmermann et al.   BIOCHEMICAL JOURNAL

Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines

(2008) Robert J Lipinski et al.   BMC CELL BIOLOGY

The decoupling of Smoothened from Gαi proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning

(2008) Wee-Chuang Low et al.   DEVELOPMENTAL BIOLOGY

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

(2008) Shunfu Piao et al.   PLoS One

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of  -catenin

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