Divalent metal ions control activity and inhibition of protein kinases

Understanding how cAMP-dependent protein kinase can catalyze phosphoryl transfer in the presence of Ca2+ and Sr2+: a QM/MM study

(2017) Ayax Pérez-Gallegos et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases

(2016) Hiruy S. Meharena et al.   PLOS BIOLOGY

Divalent Metal Ions Mg2+ and Ca2+ Have Distinct Effects on Protein Kinase A Activity and Regulation

(2015) Matthias J. Knape et al.   ACS Chemical Biology

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

(2015) Fiona P. Bailey et al.   BIOCHEMICAL JOURNAL

Generation and functions of second messengers microdomains

(2015) Riccardo Filadi et al.   CELL CALCIUM

Manganese homeostasis in the nervous system

(2015) Pan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Structural insights into mis-regulation of protein kinase A in human tumors

(2015) Jonah Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme

(2015) Ping Zhang et al.   PLOS BIOLOGY

Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer

(2014) Oksana Gerlits et al.   BIOCHEMISTRY

Metal Preferences and Metallation

(2014) Andrew W. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

Dawn of the dead: protein pseudokinases signal new adventures in cell biology

(2013) Patrick A. Eyers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Competition among Metal Ions for Protein Binding Sites: Determinants of Metal Ion Selectivity in Proteins

(2013) Todor Dudev et al.   CHEMICAL REVIEWS

Phosphoryl Transfer by Protein Kinase A Is Captured in a Crystal Lattice

(2013) Adam C. Bastidas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Price To Be Paid for Two-Metal Catalysis: Magnesium Ions That Accelerate Chemistry Unavoidably Limit Product Release from a Protein Kinase

(2012) Douglas M. Jacobsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cellular transport and homeostasis of essential and nonessential metals

(2012) Ebany J. Martinez-Finley et al.   Metallomics

Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis

(2011) Zhao Qin Bao et al.   STRUCTURE

Dynamics connect substrate recognition to catalysis in protein kinase A

(2010) Larry R Masterson et al.   Nature Chemical Biology

cAMP-dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer

(2010) Madhusudan et al.   PROTEIN SCIENCE

A Transition Path Ensemble Study Reveals a Linchpin Role for Mg2+during Rate-Limiting ADP Release from Protein Kinase A

(2009) Ilja V. Khavrutskii et al.   BIOCHEMISTRY

Factors Governing Metal−Ligand Distances and Coordination Geometries of Metal Complexes

(2009) Gopi Kuppuraj et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA

(2008) Bastian Zimmermann et al.   BIOCHEMICAL JOURNAL

CASK Functions as a Mg2+-Independent Neurexin Kinase

(2008) Konark Mukherjee et al.   CELL

Metal ions in biological catalysis: from enzyme databases to general principles

(2008) Claudia Andreini et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A helix scaffold for the assembly of active protein kinases

(2008) A. P. Kornev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA