Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

Mapping allosteric communications within individual proteins

(2020) Jian Wang et al.   Nature Communications

Conformational states dynamically populated by a kinase determine its function

(2020) Tao Xie et al.   SCIENCE

Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle

(2019) Yingjie Wang et al.   Nature Communications

Structures of the PKA RIα Holoenzyme with the FLHCC Driver J-PKAcα or Wild-Type PKAcα

(2019) Baohua Cao et al.   STRUCTURE

An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

(2019) Rigney E Turnham et al.   eLife

Inhibition of the chimeric DnaJ‐PKAc enzyme by endogenous inhibitor proteins

(2019) April M. Averill et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A Conserved Allosteric Pathway in Tyrosine Kinase Regulation

(2019) William M. Marsiglia et al.   STRUCTURE

Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity

(2019) Caitlin Walker et al.   Science Advances

Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct

(2019) Aatur D. Singhi et al.   GASTROENTEROLOGY

DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma

(2019) Monika Vyas et al.   MODERN PATHOLOGY

Molecular genomic landscapes of hepatobiliary cancer

(2018) Tatsuhiro Shibata et al.   CANCER SCIENCE

Fibrolamellar carcinoma in the Carney complex: PRKAR1A loss instead of the classic DNAJB1-PRKACA fusion

(2018) Rondell P. Graham et al.   HEPATOLOGY

Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma

(2018) Michael D. Tomasini et al.   Scientific Reports

Carney Complex

(2018) Crystal Kamilaris et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation

(2017) Duan Ni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNAJB1–PRKACAfusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

(2017) Edward R. Kastenhuber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer

(2017) Lalima G. Ahuja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

(2017) Michael Tong et al.   Nature Communications

Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates

(2017) Shane E. Tillo et al.   Cell Reports

Allosteric Communication Disrupted by a Small Molecule Binding to the Imidazole Glycerol Phosphate Synthase Protein–Protein Interface

(2016) Ivan Rivalta et al.   BIOCHEMISTRY

Fibrolamellar Hepatocellular Carcinoma: Mechanistic Distinction From Adult Hepatocellular Carcinoma

(2016) Kevin M. Riggle et al.   PEDIATRIC BLOOD & CANCER

Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma

(2016) Kevin M. Riggle et al.   PEDIATRIC RESEARCH

Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A

(2016) Jonggul Kim et al.   STRUCTURE

DNAJB1-PRKACA is specific for fibrolamellar carcinoma

(2015) Rondell P Graham et al.   MODERN PATHOLOGY

Transcriptomic characterization of fibrolamellar hepatocellular carcinoma

(2015) Elana P. Simon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into mis-regulation of protein kinase A in human tumors

(2015) Jonah Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation

(2015) Shaoyong Lu et al.   STRUCTURE

An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes

(2015) Ping Zhang et al.   STRUCTURE

Structure and Function of Human DnaJ Homologue Subfamily A Member 1 (DNAJA1) and Its Relationship to Pancreatic Cancer

(2014) Jaime L. Stark et al.   BIOCHEMISTRY

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

(2014) Woonghee Lee et al.   BIOINFORMATICS

Genomic analysis of fibrolamellar hepatocellular carcinoma

(2014) Lei Xu et al.   HUMAN MOLECULAR GENETICS

NMR mapping of protein conformational landscapes using coordinated behavior of chemical shifts upon ligand binding

(2014) Alessandro Cembran et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Tracing an allosteric pathway regulating the activity of the HslV protease

(2014) Lichi Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic architecture of a protein kinase

(2014) C. L. McClendon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma

(2014) J. N. Honeyman et al.   SCIENCE

Synchronous Opening and Closing Motions Are Essential for cAMP-Dependent Protein Kinase A Signaling

(2014) Atul K. Srivastava et al.   STRUCTURE

A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis

(2014) Stephen Boulton et al.   Scientific Reports

Fibrolamellar variant of hepatocellular carcinoma does not have a better survival than conventional hepatocellular carcinoma – Results and treatment recommendations from the Childhood Liver Tumour Strategy Group (SIOPEL) experience

(2013) V.B. Weeda et al.   EUROPEAN JOURNAL OF CANCER

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

A Systematic Review: Treatment and Prognosis of Patients with Fibrolamellar Hepatocellular Carcinoma

(2012) Michael N. Mavros et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Mapping allostery through the covariance analysis of NMR chemical shifts

(2011) R. Selvaratnam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoXS: a web server for rapid computation and fitting of SAXS profiles

(2010) D. Schneidman-Duhovny et al.   NUCLEIC ACIDS RESEARCH

A conserved deamidation site at asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry

(2010) Paul T. Jedrzejewski et al.   PROTEIN SCIENCE

Fibrolamellar Hepatocellular Carcinoma

(2009) Shu Liu et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Cooperativity and biological complexity

(2008) Adrian Whitty   Nature Chemical Biology

Cooperativity in macromolecular assembly

(2008) James R Williamson   Nature Chemical Biology

Allosteric cooperativity in protein kinase A

(2008) L. R. Masterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA