New insights into activation and function of the AMPK

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

(2022) Teng Ma et al.   NATURE

An AMPKα2-specific phospho-switch controls lysosomal targeting for activation

(2022) Kaitlin R. Morrison et al.   Cell Reports

Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis

(2022) Anees Rahman Cheratta et al.   Cell Reports

Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators

(2022) Manuel Johanns et al.   BIOCHEMICAL JOURNAL

Beneficial Effects of the Direct AMP-Kinase Activator PXL770 in In Vitro and In Vivo Models of X-Linked Adrenoleukodystrophy

(2022) Pierre-Axel Monternier et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Metformin-induced reductions in tumor growth involves modulation of the gut microbiome

(2022) Lindsay A. Broadfield et al.   Molecular Metabolism

Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis

(2022) Man K.S. Lee et al.   Molecular Metabolism

Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53

(2021) Peng Jiang et al.   MOLECULAR CELL

A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance

(2021) Yuan Liu et al.   Nature Chemical Biology

AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ

(2021) Yuejing Jiang et al.   Cell Reports

Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation

(2021) Yuejing Jiang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3

(2021) Mathieu Paquette et al.   Autophagy

Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

(2021) Xiaoming Dai et al.   MOLECULAR CELL

Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

(2021) Philipp Rhein et al.   Molecular Metabolism

Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts

(2021) Man Mohan Shrestha et al.   Frontiers in Endocrinology

AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy

(2021) Chien-Min Hung et al.   Science Advances

AMPKα2 activation by an energy-independent signal ensures chromosomal stability during mitosis

(2021) Jianlin Lu et al.   iScience

AMPKα loss promotes KRAS-mediated lung tumorigenesis

(2021) Manuela La Montagna et al.   CELL DEATH AND DIFFERENTIATION

Mice with Whole-Body Disruption of AMPK-Glycogen Binding Have Increased Adiposity, Reduced Fat Oxidation and Altered Tissue Glycogen Dynamics

(2021) Natalie R. Janzen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK: restoring metabolic homeostasis over space and time

(2021) Elijah Trefts et al.   MOLECULAR CELL

Thyroid hormone receptor phosphorylation regulates acute fasting-induced suppression of the hypothalamic–pituitary–thyroid axis

(2021) Svetlana Minakhina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy

(2021) Joshua C. Drake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an AMPK complex in an inactive, ATP-bound state

(2021) Yan Yan et al.   SCIENCE

Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering

(2021) Nicolas O. Jørgensen et al.   Molecular Metabolism

Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo-controlled, phase 2a study

(2021) Kenneth Cusi et al.   Lancet Gastroenterology & Hepatology

Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype

(2021) Laura Wilson et al.   CLINICAL SCIENCE

Personalized phosphoproteomics identifies functional signaling

(2021) Elise J. Needham et al.   NATURE BIOTECHNOLOGY

Phosphatase PHLPP2 regulates the cellular response to metabolic stress through AMPK

(2021) Yan Yan et al.   Cell Death & Disease

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

(2020) Asier González et al.   Cell Metabolism

AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair

(2020) Zhen Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

(2020) Jingyue Jia et al.   MOLECULAR CELL

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis

(2020) Peng Zhao et al.   SCIENCE

AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

(2020) Marc Dohmen et al.   Nature Communications

Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer’s model mice

(2020) Helena R. Zimmermann et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation

(2020) Jamie Bates et al.   JOURNAL OF HEPATOLOGY

miR-106a regulates cell proliferation and autophagy by targeting LKB1 in HPV-16-associated cervical cancer

(2020) Xiujie Cui et al.   MOLECULAR CANCER RESEARCH

p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival

(2020) Longfei Deng et al.   Nature Communications

Adenylate Kinase and Metabolic Signaling in Cancer Cells

(2020) Aleksandr Klepinin et al.   Frontiers in Oncology

Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

(2020) Ara Koh et al.   Cell Metabolism

Targeting AMP-activated protein kinase (AMPK) for treatment of autosomal dominant polycystic kidney disease

(2020) Xuewen Song et al.   CELLULAR SIGNALLING

AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival

(2020) Ranjithmenon Muraleedharan et al.   Cell Reports

Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK

(2020) Suhrid Banskota et al.   INFLAMMATORY BOWEL DISEASES

Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics

(2019) Zhen Chen et al.   Nature Communications

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD

(2019) Daniel Garcia et al.   Cell Reports

Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

(2019) Dhanendra Tomar et al.   Cell Reports

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

(2019) Yamei Han et al.   Nature Communications

Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol

(2019) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

AMP-activated protein kinase: the current landscape for drug development

(2019) Gregory R. Steinberg et al.   NATURE REVIEWS DRUG DISCOVERY

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates

(2019) Serge Ducommun et al.   CELLULAR SIGNALLING

Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection

(2019) Shan Li et al.   MOLECULAR CELL

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

(2019) Diana Vara-Ciruelos et al.   Cell Reports

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

(2019) Mengqi Li et al.   Cell Metabolism

Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry

(2019) Marin E Nelson et al.   EMBO JOURNAL

Cyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression

(2019) Seth Stauffer et al.   JOURNAL OF CELL SCIENCE

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling

(2019) Nan Li et al.   Nature Communications

γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

(2019) Xue Gao et al.   MOLECULAR CELL

Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling

(2019) Sebastian Schmeisser et al.   Cell Reports

Fecal transplant from resveratrol-fed donors improves glycaemia and cardiovascular features of the metabolic syndrome in mice

(2018) Ty T Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMPK-ACC signaling modulates platelet phospholipids content and potentiates platelet function and thrombus formation

(2018) Sophie Lepropre et al.   BLOOD

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

(2018) Mardiana Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Role of AMPK in Neuromuscular Biology and Disease

(2018) Athan G. Dial et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

(2018) Sandra Galic et al.   eLife

AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue

(2018) Lingyan Wu et al.   Frontiers in Physiology

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development

(2018) Nadia Boudaba et al.   EBioMedicine

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

(2018) Ryan M. Esquejo et al.   EBioMedicine

CAMKK2 promotes prostate cancer independently of AMPK via increased lipogenesis

(2018) Lucy Penfold et al.   CANCER RESEARCH

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

(2018) James S.V. Lally et al.   Cell Metabolism

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

(2018) Roger W. Hunter et al.   NATURE MEDICINE

l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism

(2018) Yusuke Adachi et al.   Molecular Metabolism

Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

(2018) Lillian J. Eichner et al.   Cell Metabolism

STIM2 interacts with AMPK and regulates calcium-induced AMPK activation

(2018) Anoop Singh Chauhan et al.   FASEB JOURNAL

Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing

(2017) Xin Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca 2+ /CaMKK2 Signaling to Enhance Tumor Cell Survival

(2017) Diana Vara-Ciruelos et al.   MOLECULAR CANCER RESEARCH

Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

(2017) Jun-ichi Sakamaki et al.   MOLECULAR CELL

AMPK β1 reduces tumor progression and improves survival in p53 null mice

(2017) Vanessa P. Houde et al.   Molecular Oncology

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

(2017) Ruixin Liu et al.   NATURE MEDICINE

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

(2017) Toby A. Dite et al.   Nature Communications

Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet

(2017) Angela Woods et al.   Cell Reports

AMPK regulates autophagy by phosphorylating BECN1 at threonine 388

(2016) Deyi Zhang et al.   Autophagy

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

(2016) Emilio P. Mottillo et al.   Cell Metabolism

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival

(2016) Rigel J. Kishton et al.   Cell Metabolism

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

(2016) Simon A. Hawley et al.   DIABETES

A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice

(2016) Qiaoli Chen et al.   DIABETOLOGIA

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

(2016) Fiona A. Ross et al.   FEBS Journal

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes

(2016) Nathan P. Young et al.   GENES & DEVELOPMENT

AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2

(2016) S. Fogarty et al.   MOLECULAR CANCER RESEARCH

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

(2016) Stephen L. Pinkosky et al.   Nature Communications

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

(2015) Rebecca J. Ford et al.   BIOCHEMICAL JOURNAL

AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

(2015) Adam L. Bujak et al.   Cell Metabolism

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates

(2015) Nolan J. Hoffman et al.   Cell Metabolism

Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction

(2015) Bethany E. Schaffer et al.   Cell Metabolism

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

(2015) Serge Ducommun et al.   CELLULAR SIGNALLING

Improved Insulin Sensitivity 3 Months After RYGB Surgery Is Associated With Increased Subcutaneous Adipose Tissue AMPK Activity and Decreased Oxidative Stress

(2015) X. Julia Xu et al.   DIABETES

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1  signaling network

(2015) H. Zhang et al.   EMBO REPORTS

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling

(2015) Ruiting Lin et al.   NATURE CELL BIOLOGY

RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK

(2015) Yawei Zhao et al.   Cell Reports

SNF4Aγ, the Drosophila AMPK γ subunit is required for regulation of developmental and stress-induced autophagy

(2014) Mónika Lippai et al.   Autophagy

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

(2014) Simon A. Hawley et al.   BIOCHEMICAL JOURNAL

Structural basis of AMPK regulation by adenine nucleotides and glycogen

(2014) Xiaodan Li et al.   CELL RESEARCH

Choreography of AMPK activation

(2014) Christopher G Langendorf et al.   CELL RESEARCH

AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice

(2014) Hayley M. O’Neill et al.   DIABETOLOGIA

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Metabolic-Stress-Induced Rearrangement of the 14-3-3  Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3  Interaction with Phosphorylated Atg9

(2014) V. K. Weerasekara et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

(2013) Yang Liu et al.   BIOCHEMICAL JOURNAL

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Coordinated regulation of AMPK activity by multiple elements in the α-subunit

(2013) Feng-Jiao Xin et al.   CELL RESEARCH

Inhibition of AMPK Catabolic Action by GSK3

(2013) Tsukasa Suzuki et al.   MOLECULAR CELL

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

(2013) Ning Wu et al.   MOLECULAR CELL

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Structural basis of AMPK regulation by small molecule activators

(2013) Bing Xiao et al.   Nature Communications

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Embryonic expression of AMPK γ subunits and the identification of a novel γ2 transcript variant in adult heart

(2012) Katalin Pinter et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

AMPK functions as an adenylate charge-regulated protein kinase

(2012) Jonathan S. Oakhill et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

(2011) Max R. Banko et al.   MOLECULAR CELL

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

PGC-1α is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle

(2010) Lotte Leick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Coordinated maintenance of muscle cell size control by AMP-activated protein kinase

(2010) Louise Lantier et al.   FASEB JOURNAL

Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells

(2010) Toran Sanli et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Activation of AMP-activated Protein Kinase by Vascular Endothelial Growth Factor Mediates Endothelial Angiogenesis Independently of Nitric-oxide Synthase

(2010) Nadine Stahmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity

(2010) Gregory R. Steinberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase

(2010) Nevzat Kazgan et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

(2009) Andrew McBride et al.   Cell Metabolism

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells

(2009) Griselda Herrero-Martín et al.   EMBO JOURNAL

AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

(2009) Nicolas Dzamko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

(2009) Lei Chen et al.   NATURE

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL