Structure of an AMPK complex in an inactive, ATP-bound state

DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy

(2020) Pietri Puustinen et al.   Autophagy

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

(2020) Jingyue Jia et al.   MOLECULAR CELL

The invasin D protein fromYersinia pseudotuberculosisselectively binds the Fab region of host antibodies and affects colonization of the intestine

(2018) Pooja Sadana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments

(2018) June Ereño-Orbea et al.   JOURNAL OF MOLECULAR BIOLOGY

Keeping the home fires burning: AMP-activated protein kinase

(2018) D. Grahame Hardie   Journal of the Royal Society Interface

Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK)

(2018) Xin Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states

(2018) Yan Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing

(2017) Xin Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress

(2017) Xiaorong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification

(2017) Fan Liu et al.   Nature Communications

Metformin extends C. elegans lifespan through lysosomal pathway

(2017) Jie Chen et al.   eLife

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

(2016) Fiona A. Ross et al.   FEBS Journal

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Probing the enzyme kinetics, allosteric modulation and activation of  1- and  2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

(2015) F. Rajamohan et al.   BIOCHEMICAL JOURNAL

Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome

(2015) Traci L Marin et al.   BMC Systems Biology

A New Versatile Immobilization Tag Based on the Ultra High Affinity and Reversibility of the Calmodulin–Calmodulin Binding Peptide Interaction

(2015) Somnath Mukherjee et al.   JOURNAL OF MOLECULAR BIOLOGY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry

(2015) Fan Liu et al.   NATURE METHODS

MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments

(2014) Meena Choi et al.   BIOINFORMATICS

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

Structural basis of AMPK regulation by adenine nucleotides and glycogen

(2014) Xiaodan Li et al.   CELL RESEARCH

Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling

(2014) John W. Scott et al.   CHEMISTRY & BIOLOGY

Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

(2014) Matthew F. Calabrese et al.   STRUCTURE

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation

(2013) Ya-Lin Zhang et al.   Cell Metabolism

Coordinated regulation of AMPK activity by multiple elements in the α-subunit

(2013) Feng-Jiao Xin et al.   CELL RESEARCH

Nutrient Sensing, Metabolism, and Cell Growth Control

(2013) Hai-Xin Yuan et al.   MOLECULAR CELL

Conserved regulatory elements in AMPK

(2013) Lei Chen et al.   NATURE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Activation of AMP-Activated Protein Kinase Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

(2013) Rachelle R. Landgraf et al.   STRUCTURE

Structural basis of AMPK regulation by small molecule activators

(2013) Bing Xiao et al.   Nature Communications

Generating conformation-specific synthetic antibodies to trap proteins in selected functional states

(2012) Marcin Paduch et al.   METHODS

AMP-activated protein kinase undergoes nucleotide-dependent conformational changes

(2012) Lei Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

T Cell Receptor-Like Recognition of Tumor In Vivo by Synthetic Antibody Fragment

(2012) Keith R. Miller et al.   PLoS One

Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain

(2011) Noriko Handa et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Development of a Novel Cross-linking Strategy for Fast and Accurate Identification of Cross-linked Peptides of Protein Complexes

(2010) Athit Kao et al.   MOLECULAR & CELLULAR PROTEOMICS

A synergistic approach to protein crystallization: Combination of a fixed-arm carrier with surface entropy reduction

(2010) Andrea F. Moon et al.   PROTEIN SCIENCE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer

(2009) S. Fogarty et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease

(2009) Aaron K. F. Wong et al.   CLINICAL SCIENCE

AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

(2009) Nicolas Dzamko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

(2009) X. J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The AMP-regulated kinase family: Enigmatic targets for diabetes therapy

(2008) G RUTTER et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY