Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

(2019) Marc Foretz et al.   Nature Reviews Endocrinology

Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycaemia

(2019) Aphrodite T Choumessi et al.   BIOCHEMICAL JOURNAL

The integrative biology of type 2 diabetes

(2019) Michael Roden et al.   NATURE

Live cell imaging of cytosolic NADH/NAD+ ratio in hepatocytes and liver slices

(2018) Ricard Masia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

(2018) Anila K. Madiraju et al.   NATURE MEDICINE

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

(2018) Roger W. Hunter et al.   NATURE MEDICINE

Self-protection of cytosolic malate dehydrogenase against oxidative stress in Arabidopsis

(2017) Jingjing Huang et al.   JOURNAL OF EXPERIMENTAL BOTANY

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

Targeting an energy sensor to treat diabetes

(2017) D. Grahame Hardie   SCIENCE

AceDRG: a stereochemical description generator for ligands

(2017) Fei Long et al.   Acta Crystallographica Section D-Structural Biology

A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast

(2016) François Collard et al.   Nature Chemical Biology

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

(2016) M. Johanns et al.   Nature Communications

I-TASSER server: new development for protein structure and function predictions

(2015) Jianyi Yang et al.   NUCLEIC ACIDS RESEARCH

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators

(2014) Yu-Chiang Lai et al.   BIOCHEMICAL JOURNAL

Choreography of AMPK activation

(2014) Christopher G Langendorf et al.   CELL RESEARCH

Inefficient Type I Interferon-Mediated Antiviral Protection of Primary Mouse Neurons Is Associated with the Lack of Apolipoprotein L9 Expression

(2014) M. Kreit et al.   JOURNAL OF VIROLOGY

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Chemoproteomic Analysis of Intertissue and Interspecies Isoform Diversity of AMP-activated Protein Kinase (AMPK)

(2013) Jiang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GalaxyRefine: protein structure refinement driven by side-chain repacking

(2013) Lim Heo et al.   NUCLEIC ACIDS RESEARCH

Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice

(2013) Yuan-Yuan Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Structural basis of AMPK regulation by small molecule activators

(2013) Bing Xiao et al.   Nature Communications

Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L

(2013) Frédéric Sorgeloos et al.   PLoS Pathogens

JLigand: a graphical tool for theCCP4 template-restraint library

(2012) Andrey A. Lebedev et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

(2012) Laurent Bultot et al.   BIOCHEMICAL JOURNAL

The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues

(2012) Tomáš Mráček et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reciprocal Phosphorylation of Yeast Glycerol-3-Phosphate Dehydrogenases in Adaptation to Distinct Types of Stress

(2012) Y. J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

The human hepatocyte cell lines IHH and HepaRG: models to study glucose, lipid and lipoprotein metabolism

(2012) Carolina Huaman Samanez et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Imaging Cytosolic NADH-NAD+ Redox State with a Genetically Encoded Fluorescent Biosensor

(2011) Yin Pun Hung et al.   Cell Metabolism

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

(2009) Nicolas Dzamko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Glucagon receptors

(2008) F. Authier et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure of α-Glycerophosphate Oxidase fromStreptococcussp.:  A Template for the Mitochondrial α-Glycerophosphate Dehydrogenase†,‡

(2007) Timothy Colussi et al.   BIOCHEMISTRY