Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype

A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome

(2020) Gennaro Napolitano et al.   NATURE

Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation

(2020) Yili Fang et al.   Cell Death Discovery

The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance

(2019) Leeanna El-Houjeiri et al.   Cell Reports

AMP-activated protein kinase: the current landscape for drug development

(2019) Gregory R. Steinberg et al.   NATURE REVIEWS DRUG DISCOVERY

PAN-AMPK ACTIVATION IMPROVES RENAL FUNCTION IN A RAT MODEL OF PROGRESSIVE DIABETIC NEPHROPATHY

(2019) Xiaoyan Zhou et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

(2019) Caterina Collodet et al.   FASEB JOURNAL

The pathobiology of polycystic kidney disease from a metabolic viewpoint

(2019) Luis Fernando Menezes et al.   Nature Reviews Nephrology

Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease

(2019) Wouter N. Leonhard et al.   EBioMedicine

A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease

(2018) Stephen L. Seliger et al.   AMERICAN JOURNAL OF NEPHROLOGY

Polycystic kidney features of the renal pathology in glycogen storage disease type I: possible evolution to renal neoplasia

(2018) Monika Gjorgjieva et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

(2018) Mardiana Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Metabolism and mitochondria in polycystic kidney disease research and therapy

(2018) Valeria Padovano et al.   Nature Reviews Nephrology

Selective Activation of AMPK β 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy

(2017) Christopher T. Salatto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease

(2017) Yu Ishimoto et al.   MOLECULAR AND CELLULAR BIOLOGY

microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

(2017) Sachin Hajarnis et al.   Nature Communications

Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet

(2017) Angela Woods et al.   Cell Reports

Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency

(2017) Ming-Yang Chang et al.   Scientific Reports

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

(2016) Arash Yavari et al.   Cell Metabolism

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes

(2016) Nathan P. Young et al.   GENES & DEVELOPMENT

Progressive development of renal cysts in glycogen storage disease type I

(2016) Monika Gjorgjieva et al.   HUMAN MOLECULAR GENETICS

Physiological Expression ofAMPKγ2RGMutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice

(2016) Xiaodong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling

(2016) Alessia Calcagnì et al.   eLife

Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease

(2016) Luis F. Menezes et al.   EBioMedicine

Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease

(2016) Meliana Riwanto et al.   PLoS One

2-Deoxy-D-Glucose Ameliorates PKD Progression

(2015) M. Chiaravalli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Food Restriction Ameliorates the Development of Polycystic Kidney Disease

(2015) G. Warner et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Pompe disease: from pathophysiology to therapy and back again

(2014) Jeong-A Lim et al.   Frontiers in Aging Neuroscience

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Metabolic reprogramming in polycystic kidney disease

(2013) Carmen Priolo et al.   NATURE MEDICINE

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy

(2013) Isaline Rowe et al.   NATURE MEDICINE

Polycystic Kidney Disease: A Case of Suppressed Autophagy?

(2013) Kameswaran Ravichandran et al.   SEMINARS IN NEPHROLOGY

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Molecular Mechanism by Which AMP-Activated Protein Kinase Activation Promotes Glycogen Accumulation in Muscle

(2011) Roger W. Hunter et al.   DIABETES

Hexokinase: a novel sugar kinase coupled to renal epithelial cell survival

(2011) R. Brooks Robey   KIDNEY INTERNATIONAL

Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress

(2011) Jonathan M. Gall et al.   KIDNEY INTERNATIONAL

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis

(2011) V. Takiar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Cyclic AMP-mediated cyst expansion

(2010) Darren P. Wallace   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inactivation of the FLCN Tumor Suppressor Gene Induces TFE3 Transcriptional Activity by Increasing Its Nuclear Localization

(2010) Seung-Beom Hong et al.   PLoS One

AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR

(2009) J Darwin King et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

AMPK controls epithelial Na+ channels through Nedd4-2 and causes an epithelial phenotype when mutated

(2009) Joana Almaça et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1

(2008) Sekiya Shibazaki et al.   HUMAN MOLECULAR GENETICS

Kidney-Targeted Birt-Hogg-Dube Gene Inactivation in a Mouse Model: Erk1/2 and Akt-mTOR Activation, Cell Hyperproliferation, and Polycystic Kidneys

(2008) M. Baba et al.   JNCI-Journal of the National Cancer Institute

A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5′ end of Pkd1

(2008) P.G. Starremans et al.   KIDNEY INTERNATIONAL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Regulation of Cl− secretion by AMPK in vivo

(2008) Patthara Kongsuphol et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Deficiency of FLCN in Mouse Kidney Led to Development of Polycystic Kidneys and Renal Neoplasia

(2008) Jindong Chen et al.   PLoS One