Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis

Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo-controlled, phase 2a study

(2021) Kenneth Cusi et al.   Lancet Gastroenterology & Hepatology

Salsalate reduces atherosclerosis through AMPKβ1 in mice

(2021) Emily A. Day et al.   Molecular Metabolism

Metformin directly suppresses atherosclerosis in normoglycemic mice via haematopoietic Adenosine Monophosphate-Activated Protein Kinase (AMPK)

(2020) Anusha Seneviratne et al.   CARDIOVASCULAR RESEARCH

Immunity and Inflammation in Atherosclerosis

(2019) Dennis Wolf et al.   CIRCULATION RESEARCH

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Defective cholesterol metabolism in haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritis

(2018) Dragana Dragoljevic et al.   EUROPEAN HEART JOURNAL

The haematopoietic stem cell niche: a new player in cardiovascular disease?

(2018) Annas Al-Sharea et al.   CARDIOVASCULAR RESEARCH

27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy

(2017) Hideyuki Oguro et al.   JOURNAL OF CLINICAL INVESTIGATION

AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE −/− mice

(2017) Ang Ma et al.   JOURNAL OF LIPID RESEARCH

Effects of dyslipidaemia on monocyte production and function in cardiovascular disease

(2017) Mohammed Shamim Rahman et al.   Nature Reviews Cardiology

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK as a Therapeutic Target for Treating Metabolic Diseases

(2017) Emily A. Day et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insulin controls food intake and energy balance via NPY neurons

(2017) Kim Loh et al.   Molecular Metabolism

Disordered haematopoiesis and athero-thrombosis

(2016) Andrew J. Murphy et al.   EUROPEAN HEART JOURNAL

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

(2015) Joseph L. Goldstein et al.   CELL

MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

(2015) Mireille Ouimet et al.   JOURNAL OF CLINICAL INVESTIGATION

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

(2015) Morgan D. Fullerton et al.   JOURNAL OF LIPID RESEARCH

Rho‐GTPase and Atherosclerosis: Pleiotropic Effects of Statins

(2015) Anping Cai et al.   Journal of the American Heart Association

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

(2014) Prabhakara R. Nagareddy et al.   Cell Metabolism

The Cholesterol Metabolite 27-Hydroxycholesterol Promotes Atherosclerosis via Proinflammatory Processes Mediated by Estrogen Receptor Alpha

(2014) Michihisa Umetani et al.   Cell Metabolism

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice

(2013) Marit Westerterp et al.   CIRCULATION RESEARCH

Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis

(2013) Andrew J Murphy et al.   NATURE MEDICINE

Regulation of Hematopoietic Stem and Progenitor Cell Mobilization by Cholesterol Efflux Pathways

(2012) Marit Westerterp et al.   Cell Stem Cell

Insulin Resistance, Hyperglycemia, and Atherosclerosis

(2011) Karin E. Bornfeldt et al.   Cell Metabolism

Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions

(2011) Clinton S. Robbins et al.   CIRCULATION

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

(2011) Andrew J. Murphy et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism

(2010) Ratna Karuna et al.   ATHEROSCLEROSIS

Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism

(2010) Ryo Suzuki et al.   Cell Metabolism

Reduction of AMP-Activated Protein Kinase α2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo

(2010) Yunzhou Dong et al.   CIRCULATION

Adenosine Monophosphate-activated Protein Kinase Induces Cholesterol Efflux from Macrophage-derived Foam Cells and Alleviates Atherosclerosis in Apolipoprotein E-deficient Mice

(2010) Dan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

(2010) L. Yvan-Charvet et al.   SCIENCE

AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

(2009) Nicolas Dzamko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity, inflammation, and atherosclerosis

(2009) Viviane Z. Rocha et al.   Nature Reviews Cardiology

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes

(2008) John W. Scott et al.   CHEMISTRY & BIOLOGY