AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

The double-edged sword of AMPK signaling in cancer and its therapeutic implications

(2015) Sang-Min Jeon et al.   ARCHIVES OF PHARMACAL RESEARCH

Probing the enzyme kinetics, allosteric modulation and activation of  1- and  2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

(2015) F. Rajamohan et al.   BIOCHEMICAL JOURNAL

Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase

(2015) Jesse I. Mobbs et al.   BIOCHEMICAL JOURNAL

Differential regulation by AMP and ADP of AMPK complexes containing different   subunit isoforms

(2015) F. A. Ross et al.   BIOCHEMICAL JOURNAL

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

(2015) Thomas E. Jensen et al.   BIOCHEMICAL JOURNAL

5′-AMP-activated protein kinase alpha regulates stress granule biogenesis

(2015) Hicham Mahboubi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides

(2015) Fábio Madeira et al.   BIOINFORMATICS

Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase

(2015) Carlos T. Pineda et al.   CELL

AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow

(2015) Yusuke Saito et al.   Cell Stem Cell

Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

(2015) D. G. Hardie   CLINICAL CANCER RESEARCH

Evidence of cancer-promoting roles for AMPK and related kinases

(2015) Tiziana Monteverde et al.   FEBS Journal

AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival

(2015) Kurt W. Fisher et al.   MOLECULAR AND CELLULAR BIOLOGY

Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance

(2015) Jiyong Liang et al.   Nature Communications

Identification of Ohnolog Genes Originating from Whole Genome Duplication in Early Vertebrates, Based on Synteny Comparison across Multiple Genomes

(2015) Param Priya Singh et al.   PLoS Computational Biology

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

(2014) Simon A. Hawley et al.   BIOCHEMICAL JOURNAL

Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

(2014) Pablo B. Martínez de Morentin et al.   Cell Metabolism

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Structural basis of AMPK regulation by adenine nucleotides and glycogen

(2014) Xiaodan Li et al.   CELL RESEARCH

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

(2014) D. Beiroa et al.   DIABETES

Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

(2014) Matthew F. Calabrese et al.   STRUCTURE

Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers

(2014) M. Tinti et al.   Open Biology

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

Coordinated regulation of AMPK activity by multiple elements in the α-subunit

(2013) Feng-Jiao Xin et al.   CELL RESEARCH

Localisation of AMPK γ subunits in cardiac and skeletal muscles

(2013) Katalin Pinter et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Conserved regulatory elements in AMPK

(2013) Lei Chen et al.   NATURE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Structural basis of AMPK regulation by small molecule activators

(2013) Bing Xiao et al.   Nature Communications

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

(2012) Laurent Bultot et al.   BIOCHEMICAL JOURNAL

Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification

(2012) Katalin Pinter et al.   CELL CYCLE

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Embryonic expression of AMPK γ subunits and the identification of a novel γ2 transcript variant in adult heart

(2012) Katalin Pinter et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

AMP-activated protein kinase undergoes nucleotide-dependent conformational changes

(2012) Lei Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates

(2012) M. Tinti et al.   Open Biology

2R and remodeling of vertebrate signal transduction engine

(2011) Lukasz Huminiecki et al.   BMC BIOLOGY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

Maintenance of red blood cell integrity by AMP-activated protein kinase α1 catalytic subunit

(2010) Marc Foretz et al.   FEBS LETTERS

Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase

(2010) Nevzat Kazgan et al.   MOLECULAR BIOLOGY OF THE CELL

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

(2010) Miguel López et al.   NATURE MEDICINE

 -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

(2010) J. S. Oakhill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ohnologs in the human genome are dosage balanced and frequently associated with disease

(2010) T. Makino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0

(2010) Stéphane Guindon et al.   SYSTEMATIC BIOLOGY

AMPK: Lessons from transgenic and knockout animals

(2009) Benoit Viollet   Frontiers in Bioscience-Landmark

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

(2009) Lei Chen et al.   NATURE

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes

(2008) John W. Scott et al.   CHEMISTRY & BIOLOGY

Structural Properties of AMP-activated Protein Kinase

(2008) Uwe Riek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

(2008) Tao Pang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The amphioxus genome and the evolution of the chordate karyotype

(2008) Nicholas H. Putnam et al.   NATURE